Navigation Links
Development of more muscular trout could boost commercial aquaculture
Date:3/10/2010

KINGSTON, R.I. March 10, 2010 A 10-year effort by a University of Rhode Island scientist to develop transgenic rainbow trout with enhanced muscle growth has yielded fish with what have been described as six-pack abs and muscular shoulders that could provide a boost to the commercial aquaculture industry.

Terry Bradley, a URI professor of fisheries and aquaculture, said his research into the inhibition of myostatin, a protein that slows muscle growth, has obtained "stunning results" in the last two years, with trout growing 15 to 20 percent more muscle mass than standard fish.

"Belgian blue cattle have a natural mutation in myostatin causing a 20 to 25 percent increase in muscle mass, and mice overexpressing myostatin exhibit a two-fold increase in skeletal muscle mass. But fish have a very different mechanism of muscle growth than mammals, so we weren't certain it was going to work," Bradley said.

According to Bradley, the number of muscle fibers in mammals is limited after birth, but in fish, muscle fiber numbers increase throughout their lifespan. Since inhibition of myostatin increases the numbers of muscle fibers, it had been a mystery as to whether inhibiting myostatin would cause an increase in muscle growth in fish.

Bradley and a team of graduate students spent 500 hours injecting 20,000 rainbow trout eggs with various DNA types designed to inhibit myostatin. Of the eggs that hatched, 300 carried the gene that led to increased muscle growth. After two years, most exhibited a "six-pack ab" effect, even though fish lack standard abdominal muscles. They also have increased musculature throughout, including a prominent dorsal hump that made them look like they had muscular shoulders.

The first generation of transgenic trout were subsequently spawned, and offspring carrying the gene in all of their muscle cells have been produced. Studies are under way to determine if the fish grow at a faster rate
'/>"/>

Contact: Todd McLeish
tmcleish@uri.edu
401-874-7892
University of Rhode Island
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sonic hedgehog gene found in an unexpected place during limb development
2. Model may offer better understanding of embryonic development
3. Chemical competition: Research identifies new mechanism regulating embryonic development
4. ACS webinar features developments in online water and wastewater monitoring
5. Rondaxe and TD2 form strategic drug development alliance
6. Zebrafish swim into drug development
7. Kentucky study advances new target for CNS drug development
8. In early heart development, genes work in tandem
9. Conservation areas threatened nationally by housing development
10. Enzyme necessary for development of healthy immune system
11. Biogen Idecs oral compound BG-12 achieves development milestones in MS and RA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... 16, 2014) – Post-menopausal women experienced improvements in ... levels or genital bleeding, after 12 weeks of ... fermented soy germ-based nutritional supplement previously shown to ... new peer-reviewed pilot study reported in a poster ... scientific meeting. , "These data documented improved ...
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... Ebola virus is spreading rapidly and to an unexpected ... in the past and the virus shows a new ... recorded before. For this reason, the German National Academy ... Science and Engineering, and the Union of the German ... on the Ebola epidemic today. , In the statement ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... has brought powerful software to the never-ending arms race ... biochemists have developed and laboratory-tested a computer program that ... bacteria use to make natural antibiotics. ... as the algorithm "K*" (pronounced K Star)-- is able ...
... University researchers want to strengthen chemistry skills starting ... ways for high school- and college-level educators to ... Melanie Cooper and Gautam Bhattacharyya, along with Michael ... molecular, cellular and developmental biology at the University ...
... of a symposium on "Defining species for threatened ... Service, will discuss the need to explicitly consider ... concepts continue to be a contentious, but largely ... between groups of organisms are identified, however, can ...
Cached Biology News:Duke software dramatically speeds enzyme design 2Duke software dramatically speeds enzyme design 3Clemson chemists present revolutionary teaching concepts 2Dealing with taxonomic uncertainty for threatened and endangered species 2
(Date:10/25/2014)...  RegeneRx Biopharmaceuticals, Inc. (OTCBB: RGRX) ("the Company" or ... International Symposium on Thymosins in Health and Disease in ... "When thymosin beta 4 (TB4) linked with rhodamine (a ... in a rodent model of stroke, it was visualized ... (the functional tissue of the brain).   The leakage of ...
(Date:10/25/2014)... 2014 Research and Markets has ... Product , Research Area & by End User - ... In this report, the global epigenetics ... areas, and end users. The product segments of the ... & consumables, kits, and reagents. The subsegments of the ...
(Date:10/22/2014)... New test innovations will be the source ... test industry, especially as companies struggle with reimbursement challenges, ... than 25 testing innovations in important disease areas in ... products. Kalorama details the new approaches its biennial survey of ... Vitro Diagnostic Tests , 9th Edition . ...
(Date:10/22/2014)... , Oct. 22, 2014  Actavis plc (NYSE: ... company, and Rhythm, a biopharmaceutical company, today announced that ... Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., which is ... treatment of diabetic gastroparesis and other GI functional disorders. ... 2 trial of relamorelin for the treatment of diabetic ...
Breaking Biology Technology:Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5
... , EMERYVILLE, Calif. , ... today announced that it will present at the 12th Annual BIO ... at 8:30 a.m. Eastern Time ( 5:30 a.m. Pacific ... presentation on our website at: , http://www.onyx-pharm.com/view.cfm/32/Event-Calendar , ...
... ... 20 Years of Experience to Biochemical Innovator, , ... Houston, TX (PRWEB) February 2, 2010 ... microbiology innovations that produce green chemicals, today announced the appointment of Daniel J. ...
... , SANTA ROSA, Calif. ... Month, EcoNugenics introduces the newest in ... Santa Rosa, CA -based nutraceutical company, founded in 1995 by integrative ... MS, LAc, has once again demonstrated excellence in being at the forefront ...
Cached Biology Technology:Onyx Pharmaceuticals to Present at the 12th Annual BIO CEO & Investor Conference 2Glycos Biotechnologies Expands Management Team with Appointment of Vice President of Research and Development 2Glycos Biotechnologies Expands Management Team with Appointment of Vice President of Research and Development 3Just in Time for Heart Health Month... TRIPLE Cardiovascular Health Support From EcoNugenics 2Just in Time for Heart Health Month... TRIPLE Cardiovascular Health Support From EcoNugenics 3
... (RNase-free) (E.C. 3.1.21.1) is a nonspecific endonuclease ... It functions by hydrolyzing phosphodiester linkages, producing ... a 3'-hydroxyl group. Ambion's RNase-free DNase I ... is recommended to degrade DNA in the ...
RABBIT ANTI RHEB (IN) Immunogen: A 15 amino acid peptide located in the central region of human Rheb....
... a unique β-agarose digesting enzyme developed at ... DNA and RNA from low melting point ... TBE, MOPS, or phosphate buffers. The gel ... TBE, MOPS, and phosphate electrophoresis buffers or ...
... GELase™ Agarose Gel-Digesting Preparation contains a ... for simple, quantitative recovery of intact DNA ... agarose gels following electrophoresis in TAE, TBE, ... be digested directly in the TAE, TBE, ...
Biology Products: