The Idaho researchers have found that NMs penetrate tumors easily, and can do so coated with antibodies or other materials that seek and destroy infected cells, while sparing normal cells.
They are looking for ways to enable NMs to more readily penetrate the targeted cells, and they report that nanowires coated with the protein fibronectin penetrate cells more easily than uncoated nanowires. In experiments with human and animal cells, they have illustrated that coated nanowires can enter and deliver a toxic agent (StxA1) that kills the cells.
Microbiologists Bohach and Hovde work with CAMBR scientists including: Maki, biochemist; Shiva Restage, organic chemist; Miramar Mishap, surface chemist and nanofabrication expert; and Brian Filanoski, a biochemist studying optical detection of bio-agents.
University of Idaho CAMBR biosensor breakthroughs have recently generated two patent applications. The technology is at the demonstration phase and work is needed to bring it to a marketable system, said Maki. All the building blocks are in place to produce a real system. With the right investment and focus, the technology could be made ready by the teams in Post Falls and Moscow in a few years," she said.
The technology developers have experience delivering commercial technologies, and that task is within the charter of the CAMBR organization, she added.
Once developed and adopted for use in hospitals, biosensors would impact both those who test positive and those who test negative for the bacteria. For the duration of the current one to three day wait for a staph culture, hospitals must isolate the patient. Insurance seldom covers that expense, so patients and hospitals currently pick up the hefty tab.
There is an immediate need for faster, more accurate staph detection, said Maki. Quick identification in hospitals could save many lives, and mil
|Contact: Joni Kirk|
University of Idaho