Navigation Links
Detrimental effect of obesity on lesions associated with Alzheimer's disease
Date:1/7/2013

In France, more than 860,000 people suffer from Alzheimer's disease and related disorders, making them the largest cause of age-related loss of intellectual function. Cognitive impairments observed in Alzheimer's disease result from the accumulation of abnormal tau proteins in nerve cells undergoing degeneration . We know that obesity, a major risk factor in the development of insulin resistance and type 2 diabetes, increases the risk of dementia during the aging process. However, the effects of obesity on 'Taupathies' (i.e. tau protein-related disorders), including Alzheimer's disease, were not clearly understood. In particular, researchers assumed that insulin resistance played a major role in terms of the effects of obesity.

The "Alzheimer & Tauopathies" team from mixed research unit 837 (Inserm/Universit Lille 2/Universit Lille Nord de France) directed by Dr. Luc Bue, in collaboration with mixed research unit 1011 "Nuclear receptors, cardiovascular diseases and diabetes", have just demonstrated, in mice, that obese subjects develop aggravated disorders. To achieve this result, young transgenic mice, who develop tau-related neurodegeneration progressively with age, were put on a high-fat diet for five months, leading to progressive obesity.

"At the end of this diet, the obese mice had developed an aggravated disorder both from the point of view of memory and modifications to the Tau protein" explains David Blum, in charge of research at Inserm.

This study uses a neurodenegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and disorders linked to the tau protein. Furthermore, it indicates that insulin resistance is not the aggravating factor, as was suggested in previous studies.

"Our research supports the theory that environmental factors contribute massively to the development of this neurodegenerative disorder" underlines the researcher. "Our work is now focussing on identifying the factors responsible for this aggravation" he adds.


'/>"/>

Contact: Press Inserm
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related biology news :

1. Research shows immune system response is detrimental to novel brain cancer therapy
2. Study finds Western diet detrimental to fetal hippocampal tissue transplants
3. New method for uncovering side effects before a drug hits the market
4. New whole plant therapy shows promise as an effective and economical treatment for malaria
5. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
6. Preventing prostate cancer through androgen deprivation may have harmful effects
7. New technique could make cell-based immune therapies for cancer safer and more effective
8. U of M to lead international virtual institute studying climatic and human effects on Earth
9. Double duty: Immune system regulator found to protect brain from effects of stroke
10. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
11. Newly discovered effects of vitamin D on cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/23/2017)... 2017 Research and Markets has announced the ... Trends - Industry Forecast to 2025" report to their offering. ... The Global ... of around 8.8% over the next decade to reach approximately $14.21 ... market estimates and forecasts for all the given segments on global ...
(Date:3/22/2017)... NEW YORK , March 21, 2017 /PRNewswire/ ... Customer Marketing Cloud used by retailers such as ... in its platform — Product Recommendations and Replenishment. Using ... to give more personalized product and replenishment recommendations ... purchases, but also on predictions of customer intent ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 , ... ... into a different cell type. Many treatments for specific cancers, such as breast, ... of targeted treatment is androgen deprivation therapy for advanced prostate cancer. , ...
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017  Kingfisher ... executive search and leadership development, and Virdis Group, global executive ... an exclusive alliance that enables clients to leverage the expertise ... "For our clients here in the Boston ... a diverse population of leadership talent throughout the US, ...
(Date:8/15/2017)... ... ... Any expert in stem cell research or stem cell medicine knows well the ... Despite their essential roles in human health and regenerative medicine, adult tissue stem ... this purpose also tag other, more abundant, non-stem tissue cells ( See 2017 Cell ...
(Date:8/14/2017)... ... August 14, 2017 , ... Every ... Key researchers in the antibody community have recently come together to address this ... in the laboratory. , The team at Thermo Fisher Scientific ...
Breaking Biology Technology: