Navigation Links
Detecting lethal diseases with rust and sand
Date:1/31/2011

The next big thing in medical diagnostics could be minutes particles of rust, iron oxide, coated with the material from which sand is formed, silicon dioxide. These magnetic nanoparticles, a mere 29 to 230 nanometers across, can be used to trap antibodies to the virus that causes cervical cancer and to the bacteria that causes potentially lethal diarrhea.

According to scientists in Vietnam, it is relatively straightforward to immobilize on nanoparticles, synthetic or monoclonal antibodies that respond to the human papilloma virus, HPV18, and the toxic gut microbe Escherichia coli O157:H7. Once trapped in this way the antibodies can be exposed to a potentially contaminated sample. If pathogen particles are present some will stick to the antibodies and this change can then be detected by a conventional test, or assay. Conventional techniques without the benefit of nanoparticles can be accurate, but the magnetic nanoparticles improve the limits of detection by allowing just these particles to be separated from the sample before carrying out the assay so that residual cells and other substances do not interfere with the test.

E. coli could be detected if it is present in a sample at much lower numbers of bacterial cells than normal allowing contamination to be traced back to source with potentially much greater precision and faster. The improved detection limit for the presence of HPV18 in cells of the cervix could offer a way to screen for cancer of this tissue that reveals problems sooner than standard screening tests and so improve the chances of successful treatment for cervical cancer.

Tran Hoang Hai of the Ho Chi Minh City Institute of Physics and colleagues explain how cervical cancer is the second most common cancer after breast cancer in women worldwide, but the conventional enzyme-linked immunosorbent assay (ELISA) diagnosis does not reveal the presence of cancerous cells at the very earliest stage. The magnetic nanoparticle approach could remedy this situation. Similarly, E. coli O157:H7 is an increasingly common cause of severe diarrhea, which can also lead to kidney failure and sometimes death. Infection spreads very quickly through ingestion of contaminated material, whether food or fecal matter, so a rapid test that can spot contamination early is essential for halting the spread of the disease.


'/>"/>

Contact: Tran Hoang Hai
thhai@vast-hcm.ac.vn
Inderscience Publishers
Source:Eurekalert

Related biology news :

1. Early investigations promising for detecting metastatic breast cancer cells
2. Researcher develops accurate method for detecting dangerous fluoride
3. Harbor seals whiskers as good at detecting fish as echolocating dolphins
4. Toward a urine test for detecting colon cancer
5. Simple test could offer cheap solution to detecting landmines
6. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
7. $1.6 million grant to lead development of resistance-detecting field kit
8. New method for detecting explosives
9. Novel veterinary procedure detecting life-threatening injuries touted
10. Detecting disease in greenhouse plants
11. Pitt researchers use fluorescence to develop method for detecting mercury in fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:6/23/2017)... and ITHACA, N.Y. , June 23, ... University, a leader in dairy research, today announced a ... to help reduce the chances that the global milk ... of this dairy project, Cornell University has become the ... the Food Supply Chain, a food safety initiative that ...
(Date:5/23/2017)... -- Hunova, the first robotic gym for the rehabilitation and functional motor sense ... Genoa, Italy . The first 30 robots will be available ... USA . The technology was developed and patented at the IIT ... Movendo Technology thanks to a 10 million euro investment from entrepreneur Sergio ... ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... Boston, MA (PRWEB) , ... August 21, 2017 ... ... healthcare consulting firm is utilizing its extensive experience with Health Economics and Outcomes ... on Electronic Health Record data. In 2014, US healthcare spending exceeded $3.0 trillion ...
(Date:8/17/2017)... ... August 17, 2017 , ... CNA Finance ... had provided a research update on Aytu Bioscience and cited promising increases in ... to Soulstring, prescription rates for Natesto® have more than doubled since March of ...
(Date:8/16/2017)... ... , ... While art and science are often thought of as two completely ... A Mesh Is Also a Snare, a group exhibition presented by the Philadelphia-based ... Gallery (EKG) on August 17 and run through September 30. An opening reception will ...
(Date:8/15/2017)... , Aug. 15, 2017 After spending the past ... support with crowdsourced data collection, GeneFo now offers this platform to ... aligning and amplifying support, adherence, and data collection vis a vis ... foundations mark the successful launch of this offer. ... GeneFo ...
Breaking Biology Technology: