Navigation Links
Detecting lethal diseases with rust and sand
Date:1/31/2011

The next big thing in medical diagnostics could be minutes particles of rust, iron oxide, coated with the material from which sand is formed, silicon dioxide. These magnetic nanoparticles, a mere 29 to 230 nanometers across, can be used to trap antibodies to the virus that causes cervical cancer and to the bacteria that causes potentially lethal diarrhea.

According to scientists in Vietnam, it is relatively straightforward to immobilize on nanoparticles, synthetic or monoclonal antibodies that respond to the human papilloma virus, HPV18, and the toxic gut microbe Escherichia coli O157:H7. Once trapped in this way the antibodies can be exposed to a potentially contaminated sample. If pathogen particles are present some will stick to the antibodies and this change can then be detected by a conventional test, or assay. Conventional techniques without the benefit of nanoparticles can be accurate, but the magnetic nanoparticles improve the limits of detection by allowing just these particles to be separated from the sample before carrying out the assay so that residual cells and other substances do not interfere with the test.

E. coli could be detected if it is present in a sample at much lower numbers of bacterial cells than normal allowing contamination to be traced back to source with potentially much greater precision and faster. The improved detection limit for the presence of HPV18 in cells of the cervix could offer a way to screen for cancer of this tissue that reveals problems sooner than standard screening tests and so improve the chances of successful treatment for cervical cancer.

Tran Hoang Hai of the Ho Chi Minh City Institute of Physics and colleagues explain how cervical cancer is the second most common cancer after breast cancer in women worldwide, but the conventional enzyme-linked immunosorbent assay (ELISA) diagnosis does not reveal the presence of cancerous cells at the very earliest stage. The magnetic nanoparticle approach could remedy this situation. Similarly, E. coli O157:H7 is an increasingly common cause of severe diarrhea, which can also lead to kidney failure and sometimes death. Infection spreads very quickly through ingestion of contaminated material, whether food or fecal matter, so a rapid test that can spot contamination early is essential for halting the spread of the disease.


'/>"/>

Contact: Tran Hoang Hai
thhai@vast-hcm.ac.vn
Inderscience Publishers
Source:Eurekalert

Related biology news :

1. Early investigations promising for detecting metastatic breast cancer cells
2. Researcher develops accurate method for detecting dangerous fluoride
3. Harbor seals whiskers as good at detecting fish as echolocating dolphins
4. Toward a urine test for detecting colon cancer
5. Simple test could offer cheap solution to detecting landmines
6. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
7. $1.6 million grant to lead development of resistance-detecting field kit
8. New method for detecting explosives
9. Novel veterinary procedure detecting life-threatening injuries touted
10. Detecting disease in greenhouse plants
11. Pitt researchers use fluorescence to develop method for detecting mercury in fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... RALEIGH, N.C. and GENEVA, Dec, 20, 2016 ... performance biometric data sensor technology, and STMicroelectronics ... across the spectrum of electronics applications, announced today ... scalable development kit for biometric wearables that includes ... integrated with Valencell,s Benchmark™ biometric sensor ...
(Date:12/16/2016)... -- The global wearable medical device market, in terms of value, ... 5.31 billion in 2016, at a CAGR of 18.0% during the ... ... medical devices, launch of a growing number of smartphone-based healthcare apps ... providers, and increasing focus on physical fitness. Furthermore, ...
(Date:12/15/2016)... 15, 2016 Advancements in biometrics ... wellness and wellbeing (HWW), and security of ... new passenger vehicles begin to feature fingerprint ... heart beat monitoring, brain wave monitoring, stress ... and pulse detection. These will be driven ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... 18, 2017  HUYA Bioscience International, (HUYA), the leader ... pharmaceutical innovations, announced today a strategic collaboration ... Investment Company (referred to as CAS Innovation). The collaboration ... by leading scientists at CAS to meet the medical ... is the first company to have recognized ...
(Date:1/18/2017)... 2017 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD; ... that develops and commercializes proprietary technologies and products ... today announced that Cameron Prange , President ... from its Board of Directors.  Mr. Prange,s resignation ... that have limited both his ability to act ...
(Date:1/17/2017)... ... January 17, 2017 , ... LGC Maine Standards ... VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 evaluates Albumin, C-reactive ... SP2 kit is prepared using the CLSI recommended “equal delta” method for linearity ...
(Date:1/17/2017)... , Jan. 17, 2017 The ... at a CAGR of around 7.5% over the ... 2025. Some of the prominent trends that the ... incidences of diseases & graft transplant surgeries and ... Material the market is categorized into immunomodulatory biomaterials, ...
Breaking Biology Technology: