Navigation Links
Detecting fetal chromosomal defects without risk
Date:5/6/2014

Chromosomal abnormalities that result in birth defects and genetic disorders like Down syndrome remain a significant health burden in the United States and throughout the world, with some current prenatal screening procedures invasive and a potential risk to mother and unborn child.

In a paper published online this week in the Early Edition of PNAS, a team of scientists at the University of California, San Diego School of Medicine and in China describe a new benchtop semiconductor sequencing procedure and newly developed bioinformatics software tools that are fast, accurate, portable, less expensive and can be completed without harm to mother or fetus.

"We believe this approach could become the standard of care for screening of prenatal chromosomal abnormalities," said Kang Zhang, MD, PhD, professor of ophthalmology, founding director of the Institute for Genomic Medicine at UC San Diego and a staff physician at the San Diego VA Healthcare System.

The incidence of chromosomal abnormalities in numbers or structure is one in 160 live births in the United States, higher in other countries. In China, for example, the rate is one in 60 live births. The effects of these abnormalities, known as aneuploidies, can be severe, from developmental delays and neurological disorders to infertility and death. The incidence rate rises with maternal age, most notably after age 35.

Current diagnoses of fetal aneuploidies often rely upon invasive tests that sample amniotic fluid or placental tissues for fetal DNA that can then be analyzed using a variety of complex and expensive methods, including full karyotyping in which the entire set of chromosomes is viewed microscopically. While highly reliable, these invasive tests may cause infections in the pregnant woman and pose as much as a 1 percent risk of miscarriage and fetal loss. Results are not available for one to two weeks, extending anxiety for families waiting for information.
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. New ultrasound device may add in detecting risk for heart attack, stroke
2. A new approach to detecting changes in GM foods
3. Closer to detecting preeclampsia
4. American Chemical Society podcast: Detecting radioactive material in nuclear waste water
5. Finnish researchers develop quick test kit for detecting phenolic compounds in drinking water
6. Detecting mirror molecules
7. Texas Biomed reports faster, more economical method for detecting bioterror threats
8. By detecting smallest virus, researchers open possibilities for early disease detection
9. Detecting breast cancers fingerprint in a droplet of blood
10. DNA test better than standard screens in identifying fetal chromosome abnormalities
11. Cannabis during pregnancy endangers fetal brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... different types of cell, including sperm, bacteria and ... flagella. These protrusions, about one-hundredth of a millimetre ... through fluid. Similar, shorter structures called cilia are ... they perform roles such as moving liquids over ... remarkably versatile: they transport mucus and expel pathogens ...
(Date:7/28/2014)... of two additional coral communities showing signs of damage from ... the 2010 spill in the Gulf of Mexico. The discovery ... of biology at Penn State University. A paper describing this ... the Gulf of Mexico will be published during the last ... the journal Proceedings of the National Academy of Sciences ...
(Date:7/28/2014)... Millions of people in the United States have a ... It can be painful and may even require surgery ... skeletal muscle wasting and, in turn, limb amputation. , ... Houston (UTHealth) Medical School, scientists tested a non-surgical preventative ... it was associated with increased blood circulation. Their ...
Breaking Biology News(10 mins):Microscopic rowing -- without a cox 2Microscopic rowing -- without a cox 3Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... A Senior Design team at Stevens Institute of Technology ... often arise during thoracic surgeries. Five undergraduate Biomedical Engineering ... issues of existing catheter design and introduces a potentially ... 21, the efforts of the Stevens Innovative Fluid Extraction ...
... Los Angeles, Calif., May 22, 2011Some men of African ... cancer, according to research conducted at the Keck School of ... genome-wide association study, published in the journal Nature Genetics ... prostate cancer in men of African descent, who tend to ...
... automated microfluidic cell culture platform to monitor the growth, ... (HSCs) at the single cell level. This ... culture conditions simultaneously and to gain new insights on ... "The ability to perform massively parallel cultures of single ...
Cached Biology News:Stevens thoracic catheter senior design team takes 1st place at regional ISPE competition 2Stevens thoracic catheter senior design team takes 1st place at regional ISPE competition 3USC research determines apparent genetic link to prostate cancer in African-American men 2UBC-led team develops platform to monitor hematopoietic stem cells 2
(Date:7/29/2014)... , July 29, 2014 ... Scanners (Whole Slide Imaging), Analytics (Image Analysis Software), Delivery ... - Global Forecasts & Trends to 2018", published by ... restraints in geographies such as North America ... Asia , and the Rest of the World ...
(Date:7/29/2014)... , July 29, 2014  ImmunoClin Corporation (IMCL) ... medicine, treatment of infectious diseases as well as ... and prevention of pathologies like cardiovascular disease, Alzheimer,s ... 2014, ImmunoClin Corporation will complete the strategic relocation ... D.C. , a key center of North ...
(Date:7/29/2014)... , July 29, 2014  Sigma-Aldrich Corporation (NASDAQ: ... energy use, increased its investment in Green Chemistry and ... the world last year, the Company announced Monday in ... Science Changed the World? The report ... honors for being a responsible corporate citizen, including recognition ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , “The invention is the ... the little Droidles a life of their own, both ...
Breaking Biology Technology:Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2
... A ... into specific T cell lineages to the activity of a single gene encoding a transcription ... the development of blood cells lineages. , ... (PRWeb UK) July 1, 2010 -- A research team in Japan has linked ...
... , WALTHAM, Mass. , July 1 ... multi-year collaborative agreement with Roche to apply X-Chem,s proprietary ... several of Roche,s high-value therapeutic targets. As part of ... research payments, success-based discovery milestones, and technology access fees. ...
... CLEVELAND , June 30 RSB Spine, LLC, a medical ... of degenerative disc disease, today announced a 50% sales increase for the ... sequentially. Additionally, the company reported record sales for the month of June. ... RSB Spine Chief Executive ...
Cached Biology Technology:The Last Checkpoint to T Cell Fate 2X-Chem and Roche Enter Into Drug Discovery Collaboration and License Agreement 2