Navigation Links
Details of bacterial 'injection' system revealed
Date:4/26/2009

s work in complementary ways," said Wall, who designed and runs the STEM facility at Brookhaven Lab. By itself, STEM cannot reveal a structure, but it gives very accurate sizes of the molecules making up particular parts, which helps scientists hone in on the structure hinted at by the other techniques. STEM also allows only good, intact molecules to be selected for analysis, which avoids errors inherent in bulk measures of mixtures of intact and broken complexes, a problem that may have affected previous analyses.

"Our reconstruction shows an overall size, shape and major sub-component arrangement consistent with previous studies," said Wall. "However, the new structure also reveals details of individual subunits and their angular orientation, which changes direction over the structure's length. We now see 12-fold symmetric features and details of connections between sub-domains both internally and externally throughout the 'needle' base."

The more accurate model therefore shows how the different parts of the injection machine fit together and may fit with other bacterial components that provide the engine to drive injection. These are important steps toward developing a detailed understanding of how the injection machine works, and to developing inhibitors that can prevent bacterial infections.

Although STEM was built more than 25 years ago, it remains a state-of-the-art tool for accurately determining the stoichiometry and homogeneity of biological complexes. It is one of the unique tools that Brookhaven Lab provides to the scientific community.

In the case of this study, said lead author Ariel Blocker of Oxford University and the University of Bristol, UK, "The STEM experiment was key because it provided unique and independent information that allowed the narrowing down of potential symmetries within the structure to a small set of testable possibilities."


'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biochemists reveal details of mysterious bacterial microcompartments
2. Researchers uncover details about how dietary restriction slows down aging
3. Study reveals surprising details of the evolution of protein translation
4. Details of evolutionary transition from fish to land animals revealed
5. Tiny details in three dimensions
6. Legionnaires bacterial proteins work together to survive
7. Scripps research team blocks bacterial communication system to prevent deadly staph infections
8. Small RNA plays parallel roles in bacterial metabolism
9. New drug targets may fight tuberculosis and other bacterial infections in novel way
10. Bacterial infections in premature babies more common than previously realized
11. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... BOSTON , Nov. 17, 2014   ... HealthCare and EMC collaborate to develop The Partners ... , The Partners Data Lake will allow ... to improve diagnostics, treatment and the lives of ... support research and clinical activities across the Partners ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Study finds laundry detergent pods, serious poisoning risk for children 2
... Forget the textbook story about tool use and language ... Instead, imagine ancient hominid children chasing frogs. Not for ... Cunnane it was a rich and secure shore-based diet ... our brains what they are today. Controversially, according to ...
... you. They strengthen the immune system and can prevent ... Planck Institute of Molecular Plant Physiology, in co-operation with ... make their contents both healthy and tasty. The researchers ... contents and genetic make-up of the hybrid. The results ...
... that a sex gene responsible for making embryos male ... brain region targeted by Parkinson's disease. Published in ... research may explain why more men than women develop ... , "Men are 1.5 times more likely to develop ...
Cached Biology News:There's something fishy about human brain evolution 2There's something fishy about human brain evolution 3Tastier tomatoes in the future? 2UCLA scientists find male gene in brain area targeted by Parkinson's 2
(Date:11/26/2014)... Charlotte, NC (PRWEB) November 25, 2014 ... High Intensity Focused Ultrasound (HIFU) devices, recently participated ... “ Small Renal Mass 360° .” Key opinion ... and therapeutic advances related to small renal masses ... learn about different ablative technologies in hands-on labs. ...
(Date:11/26/2014)... The Pittcon marketing department is pleased ... exposition mobile app, Pittcon 2015 . ... App Store for iOS and Android devices and the ... during and after the event. It acts as an ... technical sessions, Conferee Networking sessions and short courses. , ...
(Date:11/26/2014)... SoundConnect , an award winning unified ... that Darren Suders has joined the team as Director ... the partner program through innovative offerings, consistent ... Darren brings more than 10-years of channel telecommunication experience ... operations, from policy development, to partner education and to ...
(Date:11/26/2014)... -- Theravalues Corporation est fier d,annoncer le lancement ... salon Hi Europe 2014 (du 2 au 4 décembre ... Curcumine la plus biodisponible actuellement sur le marché, ... ingrédients approuvés par les règlements européens. ... la racine de curcuma ( Curcuma longa ) ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Pittcon Releases 2015 Mobile App 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3
... UPPSALA, Sweden, October 5 , - A New ... Sixth the Price of QuanTyper(TM) Without Loss of Performance, ... Market , AlphaHelix (Ticker: ALPH) has in ... meet demands for lower,instrument prices. This was made possible through know-how ...
... Oct. 5 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... E. Williams, Ph.D., Chief Executive Officer of ZymoGenetics, Inc. ... are pleased to welcome Doug to our board of ... make to Oncothyreon. His extensive experience in drug development, ...
... RIDGE, N.J., Oct. 5 Regado Biosciences, a privately ... active control agents, announced today that David J. Mazzo, ... at the Japan Biopharma Conference 2009 at the Conrad ... scheduled for 2:40pm (GMT +9:00) on October 6, 2009. ...
Cached Biology Technology:AlphaHelix Presents AmpXpress(TM) at the BIOTECHNICA Show 2Oncothyreon announces appointment of Douglas E. Williams, Ph.D., to board of directors 2Regado Biosciences To Present at the 2009 Japan Biopharma Partnering Conference on October 6, 2009 2
Removes polysaccharide and phenolic inhibitors of PCR; yields DNA greater than 50 kb in length...
Sf9 Insect Cells (Frozen) in Max-XP Medium...
HistoScan HRP Kit Universal Goat Kit...
One bottle containing 30 ml of protein solution and 0.1% sodium azide....
Biology Products: