Navigation Links
Despite damage, membrane protein structure can be seen using new X-ray technology, study reveals
Date:12/20/2010

Australian researchers have identified a way to measure the structure of membrane proteins despite being damaged when using X-ray Free-Electron Lasers (XFELs), a discovery that will help fast track the development of targeted drugs using emerging XFELs technology.

About 70% of drugs on the market today depend on the activity of membrane proteins, which are complex molecules that form the membranes of the cells in our body.

A major problem for the design of new pharmaceuticals, often known as the "membrane protein problem", is that they do not form the crystals needed to enable further investigation of the structure to design better drugs.

A major international effort is being mounted to determine the structures of membrane proteins using XFELs - large facilities that create such a bright beam of X-rays it is possible to see the X-ray light bouncing off a single molecule without forming a crystal.

Professor Keith Nugent, Laureate Professor and ARC Federation Fellow and Director of the Australian Research Council Centre of Excellence for Coherent X-ray Science (CXS) at the University of Melbourne said a key problem was that the light from an XFEL was so bright a molecule would start to disintegrate in less than one thousandth of a millionth of a millionth of a second.

In a paper published today in the journal Nature Physics, Professor Nugent and Associate Professor Harry Quiney from the ARC Centre of Excellence for Coherent X-ray Science (CXS) have developed a method by which the damage from the XFEL pulse may be included in the data analysis.

Associate Professor Quiney, also of the School of Physics at the University of Melbourne, said results showed that high-resolution molecular structures may be obtained from X-ray scattering data using a few-femtosecond pulse from an XFEL, even if the interaction resulted in significant electronic damage to the target.

"This result has far-reaching impl
'/>"/>

Contact: Diane Squires
dsquires@unimelb.edu.au
043-275-4232
University of Melbourne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Forest pests accumulating despite regulations
2. Racial differences in breast cancer treatment persist despite similar economics
3. Despite countless changes, original HIV infection lurks within
4. Pesky aphid thrives despite weak immune system
5. Despite risk, older African-Americans more likely than others to avoid flu vaccine
6. Despite claims, UK did not gas Iraqis in the 1920s, new research finds
7. Birds in Flint Hills of Kansas, Oklahoma face population decline despite large habitat
8. Organic soils continue to acidify despite reduction in acidic deposition
9. Despite peacenik reputation, bonobos hunt and eat other primates too
10. When it comes to brain damage, blankets take the place of drugs
11. UT Southwestern researchers probe kidney damage, protection in lupus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 25 million kilometres of new roads will be built ... into Earth,s last wildernesses, where they bring an influx ... Now, an ambitious study has created a ,global roadmap, ... to balance the competing demands of development and environmental ... layer that estimates that natural importance of ecosystems and ...
(Date:8/28/2014)... the world to Global Warming, has called for atmospheric ... He says that Carbon Capture, combined with limits on ... global warming getting out of control over the next ... the call during his presentation to the International Carbon ... to discuss Carbon Capture and Storage. , He ...
(Date:8/28/2014)... Biologists at Ludwig-Maximilians-Universitaet (LMU) in Munich have assigned ... genus of predatory arthropods. These animals lived in ... than related forms found in Jurassic strata. ... their shallow marine habitat and were fossilized some ... other denizens of the Silurian seas although ...
Breaking Biology News(10 mins):Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Paleontology: Oldest representative of a weird arthropod group 2
... Tech scientists contributed by invitation to an international ... Senegal, to identify strategies for the control of ... year, locusts stripped fields of crops and trees ... and food supply loss. , Larry Vaughan, associate ...
... Two Scandinavian studies have provided further evidence that ... , The studies, published online today (Thursday 28 ... Reproduction, suggest that environmental pollutants could be changing ... Y (sex determining) chromosomes and that they could ...
... accurate imaging technique have shed light on the tiny movements ... motors cooperate in a delicate choreography of steps, rather than ... imagined. , "We discovered that two molecular motors -- ... though they want to move the same cargo in opposite ...
Cached Biology News:Scientists discuss improved biopesticides for locust control in West Africa 2How the environment could be damaging men's reproductive health 2How the environment could be damaging men's reproductive health 3How the environment could be damaging men's reproductive health 4Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows 2
(Date:8/29/2014)... York (PRWEB) August 29, 2014 ... at $5.6 billion in 2019. It is expected ... 2013 to 2019, and was valued at $1.8 ... published by Transparency Market Research. , For more ... http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, titled ...
(Date:8/29/2014)... NY (PRWEB) August 29, 2014 Local ... Hills Veterinary Hospital are seeking candidates to participate in ... with osteoarthritis. The ultimate goal of this study ... stem cells into one or two arthritically affected joints ... joints. , Candidates for the current investigational study ...
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
(Date:8/28/2014)... MA (PRWEB) August 28, 2014 “This kit ... test to screen from 0 to 150 ppb,” said Mark ... is a significant benefit to plant owners and USDA-GIPSA inspection ... and other commodities. Testing can take place in a matter ... only can the plant test the feed and grain before ...
Breaking Biology Technology:Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... Wireless Facilities, Inc. , a global ... communication networks, technology networks and security systems, announced today ... and deployment services for the City of Madison, Wisconsin's ... company Cellnet, and in coordination with Madison Gas & ...
... -- A former paper converting plant in this southwestern Wisconsin ... push to become a major global player in radio frequency ... various types of labels and thermal transfer ribbons ... by the technology. The labels are intended to add efficiencies ...
... CHICAGO Anyone following this column over the last few ... allow me to arrange information into tidy boxes in some ... sense out of the information for myself). While my list ... about how lists could be used to create awareness and ...
Cached Biology Technology:Wisconsin plant is part of NCR's global RFID initiative 2Wisconsin plant is part of NCR's global RFID initiative 3Wisconsin plant is part of NCR's global RFID initiative 4Though Weakening, Biotech IPO Market Still Viable, Burril & Co. Says 2Though Weakening, Biotech IPO Market Still Viable, Burril & Co. Says 3Though Weakening, Biotech IPO Market Still Viable, Burril & Co. Says 4
... inch long PYREX NMR tubes are made from ... valves, and vacuum racks. They are designed for ... 500MHz. They have an O.D. of 4.97 + ... These NMR tubes can be used with the ...
... dye for nucleic acid electrophoresis in ... sequencing. Preparation Quantity Equivalency: A final ... 2% stock solution can be made ... comp: Dye content ~ 75% ...
Preparation TW--Compatibility: Push-on end cap seals suitable up to 70 C only -Hybridization Tube for Model HB-1D -Comp Dim: 200 80 mm -Material: borosilicate glass -Mfr Desig: Techne FHB-12...
... Gel Extraction Kit combines silica- binding technology with ... format. DNA fragments of interest are extracted from ... gel. The Gel Solubilization Solution can dissolve an ... TBE or TAE buffer. Extracted DNA fragments selectively ...
Biology Products: