Navigation Links
Despite countless changes, original HIV infection lurks within
Date:6/29/2010

, Lee's team applied a mathematical model to data originally gathered by David O'Connor, Ph.D., at the University of Wisconsin at Madison, who studies how SIV evolves. Lee's team analyzed the genetic features of three key sections of the SIV genome as they changed during the first few months of infection in eight macaque monkeys, part of an effort to quantify how quickly the process of viral escape occurs.

The research took advantage of a method known as ultradeep sequencing, which provides hundreds or thousands of glimpses of a single genetic change, compared to approximately 50 or so looks using conventional methods.

"This new technology is very exciting," said Lee. "It allows us to look at the earliest stages of infection in more depth than we could otherwise, and to quantify exactly what is going on in the body. If we can understand it more completely, we can fine-tune vaccines under development."

As expected, the team found that immune cells known as CD8+ T-lymphocytes, also known as cytotoxic T cells, are a powerful force in the life of SIV when it first causes infection. While scientists have known that the CD8 attack on the virus is strong, the latest work quantifies the body's response. They found that the original portions of the virus degrade 400 times faster in response to CD8 cells than they would have if those cells weren't a factor what scientists call significant "selective pressure" on the virus.

The team also found that SIV creates such mutants in response to the assault by CD8 cells at about the same rate as HIV does.

But the most striking finding is that the original viral genetic sequences are still present in the body months after the initial infection, at a time that scientists call the "viral set point," which occurs about two to five months after infection. It's a signal of just how difficult it is for the body to eradicate HIV from the body key portions of the virus have managed to survive des
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pesky aphid thrives despite weak immune system
2. Despite risk, older African-Americans more likely than others to avoid flu vaccine
3. Despite claims, UK did not gas Iraqis in the 1920s, new research finds
4. Birds in Flint Hills of Kansas, Oklahoma face population decline despite large habitat
5. Organic soils continue to acidify despite reduction in acidic deposition
6. Despite peacenik reputation, bonobos hunt and eat other primates too
7. Despite awareness of global warming Americans concerned more about local environment
8. CITES caviar export quotas remain steady for beluga sturgeon despite threat of extinction
9. River delta areas can provide clue to environmental changes, Texas A&M prof says
10. River delta areas can provide clue to environmental changes, Texas A&M prof says
11. Aboriginal hunting and burning increase Australias desert biodiversity, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... prairies and forests of the world can also be ... to a surprising new study led by Colorado State ... The research team analyzed 596 soil samples collected from ... diversity of below-ground life, most of which had never ... 16.2 percent of the organisms discovered in the park ...
(Date:9/30/2014)... the environmental effects of moorland burning is published today ... with the aim of relieving tensions on both sides ... EMBER (Effects of Moorland Burning on the Ecohydrology of ... moorland, which is practised predominantly to support red grouse ... peat hydrology, peat chemistry and physical properties, river water ...
(Date:9/30/2014)... something that we enjoy when we visit a national park ... of ourselves as a part of nature? A bird,s nest ... , The answers to these questions reflect different cultural ... and in cultural artifacts. , A new Northwestern University study, ... Center of Chicago and the Menominee tribe of Wisconsin, focuses ...
Breaking Biology News(10 mins):Microbes in Central Park soil: If they can make it there, they can make it anywhere 2Microbes in Central Park soil: If they can make it there, they can make it anywhere 3Grouse moor burning causes widespread environmental changes 2The cultural side of science communication 2
... and American researchers found the fossil remains of a whale, ... published, for the first time, the results of the decay ... young cetacean, possibly a baleen whale from the Mysticeti group. ... fossil remains of a whale from the Lower Pliocene (five ...
... consumers can look forward to ultra-low powered or self ... phones. This is made possible with power management and ... power optimisation and higher energy efficiency in electronic devices ... enabling capability for power management and energy harvesting. To ...
... The mouse is a standard laboratory model organism, ... techniques to analyze blood and blood-forming tissues in this ... easy-to-use laboratory resources from Cold Spring Harbor Laboratory Press ... step-by-step protocols for the preparation, enumeration, and microscopic examination ...
Cached Biology News:Story of 4.5 million-year-old whale unveiled in Huelva 2Story of 4.5 million-year-old whale unveiled in Huelva 3NTU and EDB launch S$50 million ($36 million) integrated circuit design research center 2NTU and EDB launch S$50 million ($36 million) integrated circuit design research center 3New source of classical techniques for blood-based studies in the laboratory mouse 2
(Date:10/1/2014)... BOSTON, MA (PRWEB) September 30, 2014 ... company, SoundConnect announces four new-hosted collaboration ... innovative bundles deliver high quality conferencing experiences for ... collaboration packages to choose from, businesses have optimized ... bundled solutions include audio only minutes ...
(Date:10/1/2014)... October 01, 2014 The U.S. Department ... Southern Illinois University Edwardsville as part of the Trade ... The funding is co-administered by the Department of Labor ... Secretary of Labor Thomas E. Perez and Secretary of ... in job-driven training grants to nearly 270 colleges across ...
(Date:9/30/2014)... release is available in German . ... around several quantum dots in a semiconductor layer. Quantum dots ... of atomic processes. If a short laser pulse is fired ... the quantum dot experiences a change in the electromagnetic field ... the emission of light by the dot. As soon as ...
(Date:9/30/2014)... bio-mimicking analog of one of nature,s most efficient ... team led by Alejandro Briseno of the University ... in developing long-sought polymer architecture to boost power-conversion ... electronic devices. , Briseno, with colleagues and ... Stanford University and Dresden University of Technology, Germany, ...
Breaking Biology Technology:SoundConnect Launches New Audio, Web and Video Bundles 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3
... Cellectis (Alternext: ALCLS), the French genome engineering specialist, ... (CiRA) of Kyoto University, Kyoto, Japan, have announced today ... Cellectis, genome engineering technologies with CiRA,s induced pluripotent stem ... iPS cells for use as cellular tools. ...
... Therapeutics, Inc. (Nasdaq: TSRX ) announced today that ... present "Innovative Antibacterial Drugs by Design; The Trius Therapeutics Story" ... October 26, 2010 from 5:30-9:30 p.m. PT. ... . About Trius Therapeutics ...
... International Holdings, Inc. (OTC Bulletin Board: ... medical applications and revolutionary bone graft material, today announced ... Wickwire, a distinguished Washington, D.C. based attorney and Michael ... Carparelli, to its Board of Directors.  Effective immediately, Mr. ...
Cached Biology Technology:Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 2Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 3Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 2Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 3Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 4
Phospho- (Ser) 14-3-3 Binding Motif (4E2) Mouse mAb...
Rat polyclonal to acetyl Salicylic Acid ( Abpromise for all tested applications)....
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody...
Rabbit polyclonal to UBC12 (rating: ****) ( Abpromise for all tested applications). Antigen: Synthetic peptide: RGGYIGSTYFER, corresponding to amino acids 169-180 of UBC12 Entrez Gene ID: 90...
Biology Products: