Navigation Links
Despite countless changes, original HIV infection lurks within
Date:6/29/2010

Scientists have been surprised to learn that, despite thousands of changes that viruses like HIV undergo in rapid fashion to evade the body's immune system, the original version that caused the infection is still present in the body months later.

The finding, published in the June issue of the Journal of Virology, is the result of an uncommonly detailed look at the cat-and-mouse action that takes place in an organism shortly after infection. The work is aimed at understanding the earliest stages of infection by HIV more thoroughly, to help scientists develop ways either to quash the infection outright or to develop a vaccine to prevent infection.

The research, which was conducted by scientists at the University of Rochester Medical Center, is based on an analysis of more than 100,000 genetic snippets of a virus known as SIV, or simian immunodeficiency virus, which infects monkeys and is a close cousin of HIV.

While HIV has flummoxed scientists for nearly three decades, that's certainly not because our immune system fails to respond. Rather, within two or three weeks of infection, the onslaught of immune cells puts the virus on the run to such an extent that the virus must mutate rapidly to evade the body's defenses.

HIV changes quickly and continually, creating thousands and thousands of mutated versions of itself in a process called "viral escape." The virus changes; the immune cells hunting it down change in response; and the virus changes again, and so on, in a kind of molecular arms race.

"Viral escape is a significant phenomenon in HIV it's what allows HIV to elude the immune system," said Ha Youn Lee, Ph.D., the assistant professor in the Department of Biostatistics and Computational Biology who led the project.

"The dynamics in the earliest stage of infection by HIV are incredibly complex, and understanding what happens is crucial for developing a vaccine," Lee added.

To do the study
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pesky aphid thrives despite weak immune system
2. Despite risk, older African-Americans more likely than others to avoid flu vaccine
3. Despite claims, UK did not gas Iraqis in the 1920s, new research finds
4. Birds in Flint Hills of Kansas, Oklahoma face population decline despite large habitat
5. Organic soils continue to acidify despite reduction in acidic deposition
6. Despite peacenik reputation, bonobos hunt and eat other primates too
7. Despite awareness of global warming Americans concerned more about local environment
8. CITES caviar export quotas remain steady for beluga sturgeon despite threat of extinction
9. River delta areas can provide clue to environmental changes, Texas A&M prof says
10. River delta areas can provide clue to environmental changes, Texas A&M prof says
11. Aboriginal hunting and burning increase Australias desert biodiversity, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... geologist Juliane Mller the Fram Strait is a key region ... this passage between Greenland and Svalbard warm Atlantic water flows ... west side cold Arctic water masses and sea ice push ... A considerable portion of the Atlantic water cools here on ... The circulation of the water caused in this manner drives ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/21/2014)... involves the pancreas digesting itself resulting in severe abdominal ... UK around 20,000 patients are diagnosed with the disease ... and treatment is restricted to intravenous fluid and nutritional ... of Life Sciences, who led the research, said "The ... gall stones and excessive alcohol intake combined with a ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3New feeding tube connectors will improve patient safety 2Insulin offers new hope for the treatment of acute pancreatitis 2
... you get a picky young eater who refuses everything to ... try nutritious foods when all they want is something sweet ... mealtime struggles? In her new book, ... to Raise Healthy Eaters" (Healthy Learning, May 2012), registered dietitian ...
... (May 29, 2012) Physicians and researchers at John Theurer ... cancer centers, will present the latest findings in blood-cancer research ... meeting in Chicago on June 1-5. Their involvement in these ... to bolster its research program. "We are ...
... Organic Electronics research group at Linkping University previously developed ... ions, as well as biomolecules. Tybrandt has now succeeded ... a similar way to traditional silicon-based electronics. ... carrier consists of chemical substances with various functions. This ...
Cached Biology News:'Eat your vegetables!' New book redefines how to raise healthy eaters 2John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting 2
(Date:8/21/2014)... MO (PRWEB) August 21, 2014 ... service biopharmaceutical contract development and manufacturing organization (CMO) ... Progenics Pharmaceuticals, Inc., an oncology company focused on ... treating cancer, to manufacture the anti-prostate specific membrane ... ADC product candidate. Under the agreement the ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
(Date:8/20/2014)... -- PAREXEL International Corporation (NASDAQ: PRXL ) announced ... Healthcare Conference in New York.  Ingo Bank , ... making a presentation on PAREXEL and discussing business developments ... A live webcast of the discussion will ... at www.PAREXEL.com in the Upcoming Events portion ...
(Date:8/20/2014)... NJ (PRWEB) August 20, 2014 WriteResult®, ... announced today that it has expanded its myPROpad™ ePRO ... the EQ-5D-5L, one of the most widely used ... measuring general health status. The EQ-5D is used during ... generate a measure that can be used to demonstrate ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3PAREXEL International To Present At Baird Healthcare Conference 2EQ-5D™ Assessment Now Available for iPad 2
... Thomson Reuters, the,world,s leading source of intelligent ... the National Cancer Institute (NCI) has,joined the ... comprehensive resource for biomarker intelligence to provide,pharmaceutical, ... for assessing and tracking a potential biomarker ...
... ... Initiatives, BEDFORD, Mass., Sept. 3 ... technology with its OmniPod(R),Insulin Management System, today announced the appointment of ... this,role, Mr. Arthur will lead the company,s business development strategy,including pursuing ...
... a Magellan,Biosciences company and leader in novel HPLC ... QA/QC, life science, and,analytical-chemistry customers worldwide, announced that ... American Technology Innovation Award in the,field of integrated ... to ESA,s Vice President of HPLC Products and ...
Cached Biology Technology:The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters 2The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters 3Insulet Appoints Bill Arthur as Vice President of Business Development 2Insulet Appoints Bill Arthur as Vice President of Business Development 3Insulet Appoints Bill Arthur as Vice President of Business Development 4ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 2ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 3
... The "egg crate" style strip holder is ... bottom strips. Linkage: This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (Z71,456-9) or contact customer service ...
... Streptavidin-AP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
... pre-amplifier suitable for a broad range of ... recording physiological signal such as ECG, EMG, ... for use with a wide range of ... a stimulus artefact clamp to avoid saturation ...
Biology Products: