Navigation Links
Designing probiotics that ambush gut pathogens
Date:9/7/2009

Researchers in Australia are developing diversionary tactics to fool disease-causing bacteria in the gut. Many bacteria, including those responsible for major gut infections, such as cholera, produce toxins that damage human tissues when they bind to complex sugar receptors displayed on the surface of cells in the host's intestine.

At the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, today (8 September), Professor James Paton and colleagues from the University of Adelaide explained how they had added molecular mimics of these host cell receptors onto the surface of harmless bacteria capable of surviving in the human gut. If given during an infection caused by a toxin-producing bacterium, these "receptor-mimic probiotics" will bind the toxins in the gut very strongly, thereby preventing the toxins from interacting with receptors on host intestinal cells and causing disease.

Effective vaccines are not yet available for many diarrhoeal diseases; and trying to control or treat these diseases with antibiotics can lead to the development of drug-resistance. One advantage of this approach to treatment is that the pathogenic bacteria are unlikely to develop a resistance to it, as that would destroy the basic mechanism by which they cause disease.

A further advantage is that the receptor-mimic bacteria bind toxins more strongly than previous technologies in which synthetic receptors were displayed on inert silica particles. They are also more cost effective, as the bacteria can be grown cheaply in large-scale fermenters.

"We initially developed this technology to prevent disease caused by strains of E. coli bacteria that produce Shiga toxin. These include the infamous E. coli O157 strain, which causes outbreaks of severe bloody diarrhoea and the potentially fatal haemolytic uraemic syndrome. Our prototype receptor mimic probiotic provided 100% protection against otherwise fatal E. coli disease in an
'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows
2. Swedish university honors probiotics scientist
3. Flexible neck in cell-receptor DC-SIGN targets more pathogens
4. UGA licenses invention that kills food-borne pathogens in minutes
5. Rapid test for pathogens developed by K-State researchers
6. New UGA invention effectively kills foodborne pathogens in minutes
7. Researcher discovers pathway plants use to fight back against pathogens
8. Technology uses live cells to detect food-borne pathogens, toxins
9. Can interacting pathogens explain disease patterns?
10. Pathogens use previously undescribed mechanism to sabotage host immune system
11. K-State specialist in tick-borne pathogens receives $1.8 million grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "Global Facial Recognition Market ... http://photos.prnewswire.com/prnh/20130307/600769 Facial ... of individuals. Facial recognition system measures the overall ... jaw edges, mouth, and the distance between eyes. ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... October 31, 2012 Scientists at The Scripps ... of an important set of enzymes. The new inhibitors, ... used to study the functions of enzymes known as ... regulate. Early tests in mouse macrophages suggest that DAGL-inhibiting ...
... German . , In male songbirds of the ... spring, which leads to an increase in song activity during ... evidence so far about such a clear relationship between hormonal ... degree of seasonal changes of the environment. Researchers of the ...
... identified a molecular ,flag, in women with breast cancer who ... drug tamoxifen. Tamoxifen used alongside traditional chemotherapy and ... breast cancers, is required by the tumour to grow; it ... to one third. However, about one third of patients ...
Cached Biology News:New inhibitors of elusive enzymes promise to be valuable scientific tools 2New inhibitors of elusive enzymes promise to be valuable scientific tools 3Testosterone regulates solo song of tropical birds 2Scientists unravel resistance to breast cancer treatment 2
(Date:12/24/2014)... Wash. , Dec. 24, 2014   BioLife ... leading developer, manufacturer and marketer of proprietary clinical grade ... media and precision thermal shipping products for ... that it will hold its 2015 Annual Meeting of ... Because the expected date for the Annual Meeting ...
(Date:12/24/2014)... St. Louis, Missouri (PRWEB) December 23, 2014 ... and targeting Swiss biotechnology company, Syngenta, are in the ... for pretrial proceedings. The consolidated case is In Re: ... in the U.S. District Court for the District of ... litigation (MDL) has been handed over to U.S. District ...
(Date:12/24/2014)... 2014 SoundConnect’s ... to introduce cutting edge communication technology, provide ... of platform upgrades. This webinar series demonstrates ... in their quest to leverage web conferencing’s ... to SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ... The only negative is the housing market remaining soft. ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... advanced energy research , , MONTREAL, July 7 ... technology company, today announced that it will jointly form ... Edmonton and the Alberta Energy Research Institute (AERI). , ... demonstration of novel catalytic conversion processes to produce advanced ...
... following letter is being released by CEL-SCI Corporation (NYSE Amex: ... , , Recently we have been hearing a great deal about the ... this is no big deal since it does not seem that serious and, ... both counts! In this letter I will show you where in the ...
... REDWOOD CITY, Calif., July 7 OncoMed Pharmaceuticals, Inc., ... cancer stem cells, today announced the appointment of Sunil ... Development. In this new position, Mr. Patel will ... directly to Paul Hastings, OncoMed,s President and Chief Executive ...
Cached Biology Technology:Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 3CEL-SCI Corporation Releases Letter to Shareholders 2CEL-SCI Corporation Releases Letter to Shareholders 3CEL-SCI Corporation Releases Letter to Shareholders 4CEL-SCI Corporation Releases Letter to Shareholders 5CEL-SCI Corporation Releases Letter to Shareholders 6CEL-SCI Corporation Releases Letter to Shareholders 7OncoMed Pharmaceuticals Appoints Sunil Patel Senior Vice President, Corporate Development 2
... ultimate in utility and flexibility press-to-seal silicone ... needs of the researcher. They are available ... as sheet material that can be easily ... are autoclavable and non-cytotoxic and can be ...
Argon Calibration Source...
SHEEP ANTI ESCHERICHIA COLI...
Recombinant Rat Leptin, CF...
Biology Products: