Navigation Links
Designing probiotics that ambush gut pathogens

Researchers in Australia are developing diversionary tactics to fool disease-causing bacteria in the gut. Many bacteria, including those responsible for major gut infections, such as cholera, produce toxins that damage human tissues when they bind to complex sugar receptors displayed on the surface of cells in the host's intestine.

At the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, today (8 September), Professor James Paton and colleagues from the University of Adelaide explained how they had added molecular mimics of these host cell receptors onto the surface of harmless bacteria capable of surviving in the human gut. If given during an infection caused by a toxin-producing bacterium, these "receptor-mimic probiotics" will bind the toxins in the gut very strongly, thereby preventing the toxins from interacting with receptors on host intestinal cells and causing disease.

Effective vaccines are not yet available for many diarrhoeal diseases; and trying to control or treat these diseases with antibiotics can lead to the development of drug-resistance. One advantage of this approach to treatment is that the pathogenic bacteria are unlikely to develop a resistance to it, as that would destroy the basic mechanism by which they cause disease.

A further advantage is that the receptor-mimic bacteria bind toxins more strongly than previous technologies in which synthetic receptors were displayed on inert silica particles. They are also more cost effective, as the bacteria can be grown cheaply in large-scale fermenters.

"We initially developed this technology to prevent disease caused by strains of E. coli bacteria that produce Shiga toxin. These include the infamous E. coli O157 strain, which causes outbreaks of severe bloody diarrhoea and the potentially fatal haemolytic uraemic syndrome. Our prototype receptor mimic probiotic provided 100% protection against otherwise fatal E. coli disease in an animal model." said Professor Paton, "We have also developed similar receptor mimic probiotics that are capable of preventing cholera and travellers' diarrhoea. As well as being able to treat disease, these probiotics could be given to vulnerable populations following natural disasters to help prevent outbreaks of diseases like cholera".


Contact: Dianne Stilwell
Society for General Microbiology

Related biology news :

1. Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows
2. Swedish university honors probiotics scientist
3. Flexible neck in cell-receptor DC-SIGN targets more pathogens
4. UGA licenses invention that kills food-borne pathogens in minutes
5. Rapid test for pathogens developed by K-State researchers
6. New UGA invention effectively kills foodborne pathogens in minutes
7. Researcher discovers pathway plants use to fight back against pathogens
8. Technology uses live cells to detect food-borne pathogens, toxins
9. Can interacting pathogens explain disease patterns?
10. Pathogens use previously undescribed mechanism to sabotage host immune system
11. K-State specialist in tick-borne pathogens receives $1.8 million grant
Post Your Comments:
(Date:11/4/2015)... November 4, 2015 --> ... report published by Transparency Market Research "Home Security Solutions Market ... Forecast 2015 - 2022", the global home security solutions market is ... by 2022. The market is estimated to expand at ... 2015 to 2022. Rising security needs among customers at ...
(Date:10/29/2015)... , Oct. 29, 2015   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... Tech Association (MHTA) as one of only three finalists ... "Software – Small and Growing" category. The Tekne Awards honor ... have shown superior technology innovation and leadership. ...
(Date:10/29/2015)... , Oct. 29, 2015 Daon, a ... that it has released a new version of its ... in North America have already ... v4.0 also includes a FIDO UAF certified server ... already preparing to activate FIDO features. These customers include ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 The Global Genomics ... professional and in-depth study on the current state ... ) , The report ... definitions, classifications, applications and industry chain structure. The ... markets including development trends, competitive landscape analysis, and ...
(Date:11/24/2015)... , Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: ... in New York on Wednesday, December 2 ... Torley , president and CEO, will provide a corporate overview. ... York at 1:00 p.m. ET/10:00 a.m. PT . ... relations, will provide a corporate overview. --> th ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
(Date:11/24/2015)... New York , November 24, 2015 ... to a recent market research report released by Transparency ... projected to expand at a CAGR of 17.5% during ... "Non-invasive Prenatal Testing Market - Global Industry Analysis, Size, ... estimates the global non-invasive prenatal testing market to reach ...
Breaking Biology Technology: