Navigation Links
Designing new molecular tools to study the life and death of a cancer cell
Date:2/15/2011

nd their synthetic modulators has become a new frontier for biomedical research and pharmaceutical development. We have chosen a proline containing tetrapeptide as the model to develop new peptidomimetic molecules to study the role of proline and tetrapeptide in the binding of XIAP protein and potential inhibition of XIAP mediated protein-protein interactions critical for apoptotic signaling in cancer cells. Our results suggest that these tetrapeptide analogs can be further developed into new molecular tools to analyze the mechanisms of protein-protein interactions and signal transduction pathways of XIAP in cancer and potential leads to develop anticancer drugs. This study combined the techniques in structure-based drug design, chemistry, and cancer biology and expertise and resources at institutions in America and China. It is an example of international collaboration to apply chemistry to biology and medicine with the long term goal of finding new anticancer therapeutics".

The research team used the crystal structure of a known tetrapeptide AVPI derived from Smac protein bound to XIAP protein as the guide to design a series of peptidomimetic analogs containing a conformationally constrained proline mimetic exo-2-azabicyclo[2.2.1]heptane-3-carboxylic acid. Structural analyses using nuclear magnetic resonance (NMR) and molecular modeling showed that some of these analogs can mimic the conformations of the parent tetrapeptide. Using a fluorescence polarization assay, one of these analogs was shown to be potent like the parent tetrapeptide in binding XIAP protein. This raises the possibility that such an analog may inhibit the antiapoptotic function of XIAP (a protein inhibitor of apoptosis), thus removing the roadblock of the death signal to kill a cancer cell.

Dr. John Reed, who led the binding and biological studies of these molecules in La Jolla, California, said, "The progress made through our collaborations with Dr. Huang and colleagues
'/>"/>

Contact: Dr. Ziwei Huang
huangz@upstate.edu
315-464-7950
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Designing more effective anti-HIV antibodies
2. Designing touch-sensitive virtual reality tools to train and test tomorrows surgeons
3. Designing probiotics that ambush gut pathogens
4. Molecular network influences development of chronic lymphocytic leukemia
5. Polymer membranes with molecular-sized channels that assemble themselves
6. Molecular medicine could avert predicted catastrophic vision loss in the aged
7. New book highlights the cellular and molecular determinants of brain wiring
8. Scientists discover molecular switch that contributes to cellular aging process
9. Molecular fossil
10. Association for Molecular Pathologys 16th Annual Meeting and Exhibits
11. Understanding diabetes at the molecular level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... A sleep-promoting circuit located deep in the primitive ... Discovered by researchers at Harvard School of Medicine and ... Sciences, this is only the second "sleep node" identified ... both necessary and sufficient to produce deep sleep. , ... the study demonstrates that fully half of all of ...
(Date:9/18/2014)... into the Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne ... similar to that caused by Ebolavirus, has identified new ... the potential to lead to novel targets for therapeutic ... reported in a paper published today in the journal ... the Texas Biomedical Research Institute and their colleagues, represents ...
(Date:9/18/2014)... of researchers from McGill University and the Quebec ... polyethylene ,microbeads, Canadian Journal of Fisheries and ... from cosmetics, household cleansers, or industrial cleansers, to ... to their small size and buoyancy, they may ... are a global contaminant in the world,s oceans, ...
Breaking Biology News(10 mins):No sedative necessary: Scientists discover new 'sleep node' in the brain 2Research milestone in CCHF virus could help identify new treatments 2Microplastic pollution discovered in St. Lawrence River sediments 2
... press release is available in French . ... are not slower but rather wiser than young brains, which ... according research undertaken at the University Geriatrics Institute of Montreal ... Univeristy of Montreal. "The older brain has experience and knows ...
... important processes during drilling operations. In deepwater drilling, controlling pressure ... the drilled hole can result in blowouts, leading to disastrous ... The deeper the well, the higher the pressure, and the ... drilling, when the pressure applied to balance the hydrocarbon pressure ...
... scientists and collaborators has identified a cellular protein that plays ... online today in separate studies in the journal Nature, ... world,s most deadly viruses. Ebola causes hemorrhagic fever ... humans. The virus is of concern both as a global ...
Cached Biology News:Clinical study shows young brains lack the wisdom of their elders 2A math-based model for deep-water oil drilling 2A math-based model for deep-water oil drilling 3Single protein, key to ebola virus infection, could aid in drug design 2
(Date:9/19/2014)... 19, 2014 Pfenex Inc. (NYSE MKT: PFNX), ... high-value and difficult to manufacture proteins including biosimilar therapeutics, ... 21 st Annual NewsMakers in the Biotech Industry ... Bertrand Liang , chief executive officer of Pfenex, will ... business strategy on Friday, September 26, 2014 at 10:00 ...
(Date:9/19/2014)... 2014 , The first grants ... Paediatric Endocrinology (ESPE) Meeting  Investment supports innovative ... in the field of growth  , EMD ... Germany , today announced the first recipients of ... awards were announced during a Satellite Symposium organized by ...
(Date:9/18/2014)... Sept. 18, 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 ... Acid Industry" and "2014 Deep Research Report on ... its research database. Photo - ... Report on Global and China Acetic Acid Industry" ... China and Global Acetic ...
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest Moniz ... National Lab Day on the Hill. The event highlighted ... system. Durbin and Risch also formally launched the Senate ... the reach of the national labs as leaders in ... of our nation's most pressing challenges. , "The national ...
Breaking Biology Technology:Pfenex to Present at Upcoming Industry Conference on September 26 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... 23 Eisai Corporation of,North America and its ... Food and Drug Administration (FDA) has approved a ... prevention of,chemotherapy-induced nausea and vomiting (CINV). ALOXI Capsules ... prevention of acute nausea and,vomiting following initial and ...
... WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology and ... in China and the United,States, today announced that ... of Synthetic Chemistry., (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ... Dr. Shuhui Chen, Chief Scientific,Officer of WuXi PharmaTech., ...
... Aug. 22 /PRNewswire-FirstCall/ - OncoGenex,Pharmaceuticals (NASDAQ: OGXI ... sodium, received Fast Track designation from the U.S. ... for progressive,metastatic prostate cancer. OGX-011 is currently completing ... breast cancer, and is designed to,inhibit the production ...
Cached Biology Technology:FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 2FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 3WuXi PharmaTech Promotes Dr. Rujian Ma to VP of Synthetic Chemistry 2FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 2FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 3FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 4
...
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
... Magnetic Bead Separation is a powerful ... clinical applications. Typical applications are DNA/RNA or ... ,This has been fully automated on ... magnetic separator Te-MagS. ,In combination with ...
... Collection of Cell Cultures (ECACC) has been ... academia and government institutes for over seven ... designed to introduce candidates to cell culture ... on more specialist areas such as planning ...
Biology Products: