Navigation Links
Designing more effective anti-HIV antibodies
Date:11/19/2010

Boston, Mass. Although people infected with HIV produce many antibodies against the protein encapsulating the virus, most of these antibodies are strangely ineffective at fighting the disease. A new study suggests why some of the most common of these antibodies don't work: they target the protein in a form it takes after the virus has already invaded the cell, when it's too late, report researchers at Children's Hospital Boston and their colleagues.

The findings, published online Nov. 14 in the journal Nature Structural & Molecular Biology, refocus attention on the rare group of neutralizing antibodies that do work, described by the team in an earlier study. These antibodies home in on the protein at an earlier moment when the virus latches onto a healthy cell. Many people believe an effective HIV vaccine will need to greatly expand this rare antibody immune response to block infection. Children's has filed for patents on two new proteins designed to expand this rare antibody response.

"The key finding of this paper is that we can distinguish the shape of the protein targeted by useful antibodies," said senior author Bing Chen, PhD, of the Department of Molecular Medicine at Children's. "That means we can think about designing immunogens trapped in this defined structure and ways to prevent the protein from forming into an irrelevant conformation."

The same HIV protein, known as gp41, takes two such dramatically different configurations that it reacts with two different kinds of antibodies, Chen's group shows. In HIV, the protein travels under wraps on the surface of virus particles. When the virus locks onto a healthy cell, the protein briefly unfolds and stretches out to its full length, extending out like a person reaching high overhead. This is the shape that generates rare but useful neutralizing antibodies in some people.

Then comes another shape change. After taking hold of the cell membrane, the protein folds
'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Designing touch-sensitive virtual reality tools to train and test tomorrows surgeons
2. Designing probiotics that ambush gut pathogens
3. New needle-free HPV vaccine increases effectiveness, availability in developing world
4. Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units
5. UV light nearly doubles vacuums effectiveness in reducing carpet microbes
6. Succimer found ineffective for removing mercury
7. Cheaper, more effective treatment of type 1 Gaucher disease possible
8. Second-generation device more effective in capturing circulating tumor cells
9. RD114 envelope proteins provide an effective and versatile approach to pseudotype lentiviral vectors
10. Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
11. More effective weight control strategies are urgently needed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Showcase, Hall E -   EyeLock Inc. , a market ... showcase its EyeLock ID technology integrated in a 3D printed ... Oak Ridge National Laboratory (ORNL) at the 2015 ... technology is being used to validate the driver and authorize ...
(Date:1/22/2015)... Report Issued by Small Cap IR. In 2011, Nilson Report,s ... at merchants on the leading payment cards rose to $135.3 ... and prepaid cards reached 6.54 billion.  Eight million credit card ... in 2012, and credit and debit card fraud resulted in ...
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... As if being admitted to the hospital werent bad ... becoming infected with a superbug bacterium, Clostridium difficile (C. ... intestinal cells by causing them to burst open, allowing ... in severe diarrhea and, in rare cases, death. Abraham ...
... Weinheim, September 04, 2007 - The term "biotechnology" elicits a ... hostility. Alan McHughen from the University of California in Riverside ... knowledge of biotech, popular misperceptions, scientific illiteracy and the role ... US and Europe" Who benefits from agricultural biotech only ...
... In the dynamic world of the developing brain, neural stem ... ventricles. These newborn neurons then migrate along the stem cell ... functions. Now, scientists have discovered a key mechanism of this ... in other developmental processes and diseases, including cancer. ...
Cached Biology News:Curbing C. difficile's toxin production 2How the public perceives biotech 2Neural stem cell study reveals mechanism that may play role in cancer 2Neural stem cell study reveals mechanism that may play role in cancer 3Neural stem cell study reveals mechanism that may play role in cancer 4
(Date:12/24/2014)... GMO corn cases filed across the United States, ... of being consolidated in a Kansas federal court for pretrial ... 162 Corn Litigation, MDL No. 2591 in the U.S. District ... Syngenta GMO corn multidistrict litigation (MDL) has been handed over ...
(Date:12/24/2014)... BOSTON, MA (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge communication ... partners of platform upgrades. This webinar series demonstrates ... their quest to leverage web conferencing’s most innovative ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility Center ... treasurer for the American Society for Reproductive Medicine (ASRM), a ... reproductive medicine. In his new role as treasurer, Dr. ... will have a voice in furthering the mission of ASRM. ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... , CRACKS AMAZON.COM BEST SELLER LIST IN SCIENCE , ... best selling science books , SEATTLE, Nov. 17 Despite ... about the controversial theory of intelligent design made Amazon.com,s list of ... world marks 150 years since Charles Darwin published his own theory ...
... ... Readers, Choice Award for Best Application of Green Computing. The award was presented ... in Portland, Ore. , ... Portland, OR (Vocus) Nov. 17, 2009 --- The U.S. Department of Energy,s (DOE) ...
... , SOLANA BEACH, Calif. and HAMILTON, New Zealand, Nov. ... enzyme-based products for DNA extraction and other life sciences ... note documenting that its forensic GEM(®) Saliva DNA ... high-quality, ready-to-analyze DNA from buccal swab samples compatible with ...
Cached Biology Technology:Intelligent Design Book Delivers Blow to Darwin 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 3Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 4Forensic Scientists at Kansas City Crime Lab Release Validation Report Confirming Zygem's forensicGEM(R) Kit is a Reliable, Rapid Method for Extracting DNA From Saliva 2Forensic Scientists at Kansas City Crime Lab Release Validation Report Confirming Zygem's forensicGEM(R) Kit is a Reliable, Rapid Method for Extracting DNA From Saliva 3Forensic Scientists at Kansas City Crime Lab Release Validation Report Confirming Zygem's forensicGEM(R) Kit is a Reliable, Rapid Method for Extracting DNA From Saliva 4
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Mouse monoclonal [11C9] to Zeralenone ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to BSA: Zeralenone...
AK6 Antibody...
...
Biology Products: