Navigation Links
Designer piercings: New membrane pores with DNA nanotechnology
Date:11/4/2013

st 14 nanometres along and 5.5 nanometres across (around 10,000 times smaller than the width of a human hair). This formed the main part of their artificial nanopore. However, to insert the tube into a cell membrane, a key challenge had to be addressed: the water-soluble DNA-based structure will not embed itself into the greasy membrane which is composed of lipids.

To overcome this, the scientists chemically attached to the DNA tube two large anchors, made of molecules which have a natural affinity for lipids. These structures were then able to embed the tube into the membrane. These structures, which are based on naturally derived porphyrins, were designed by a group led by Dr Eugen Stulz (University of Southampton).

"Porphyrin molecules have ideal characteristics for our purposes," Stulz explains. "They are a strong membrane anchor, which locks the nanopore securely into the lipid membrane. In addition, they are fluorescent, which means they are easy to see and study. This makes them superior to other technologies."

The pores were characterised with electrical and fluorescence measurements in collaboration with Dr Ulrich Keyser (Cavendish Laboratory, Cambridge).

The simplicity of self-assembling a structure with only two anchors (previous studies used 26 or even 72 such anchors) greatly streamlines the design and synthesis of nanopores.

"In future, this new process will enable us to tailor DNA nanopores for a much wider range of applications than are currently possible," Keyser says.

The ability to create synthetic channels through lipid membranes enables numerous applications in the life sciences. In the first instance, DNA nanopores are of great interest for biosensing, such as rapid DNA analysis.

But tailored pores can also be expected to aid the development of new drugs. Prototype drugs are typically designed to affect a biological target, but are not engineered to cross the cell membrane. Self-assembled
'/>"/>

Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-020-310-83846
University College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Molecular biology: Designer of protein factories exposed
2. Finland to lead the way as a designer of cellulose-based products
3. Designer bacteria may lead to better vaccines
4. Biologists engineer algae to make complex anti-cancer designer drug
5. University of Albertas designer compounds inhibit prion infection
6. African scientist, designer partner to fashion anti-malaria garment that wards off bugs
7. Super-thin membranes clear the way for chip-sized pumps
8. Researchers capture images of open channel that moves proteins across cell membranes
9. Study: Acidity can change cell membrane properties
10. How bacteria integrate autotransporters into their outer membrane
11. Photosynthesis: Membranes in tight corners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The announcement comes as demand for fire ... Ireland,s foremost records management company, has ... an impressive track record of clients within the first 12 ... management sector in Dubai . As a ... employ a further eight staff members at its Irish headquarters. ...
(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
(Date:4/10/2015)... April 10, 2015 Research and ... the "Security Competitive Profiles - NEC" report ... NEC will continue to supply a range ... market, with a company focus on the development of ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2
... are those that occur outside their natural range and ... can be plants, animals or microorganisms that are introduced ... tourism, travel or trade, or when domestic animals become ... the rising cost of invasive species on a global ...
... were once credited with magical healing powers but are now ... but the cause of numerous diseases such as diabetes if ... the vital role played by more complex sugars in many ... This all emerged in a recent workshop organised by ...
... (Jan. 16, 2008) -- Two major federal grants have been ... in New York City. Dr. Kenneth W. Griffin ... from the National Institute on Drug Abuse (NIDA) for research ... previously delivered to urban minority youth attending New York City ...
Cached Biology News:Scientists call for urgent research into 'real' impacts of invasive species 2Scientists call for urgent research into 'real' impacts of invasive species 3ESF's workshop restores good name of sugar 2ESF's workshop restores good name of sugar 32 federal public health grants awarded to Weill Cornell Medical College 2
(Date:5/27/2015)... , May 27, 2015  RXi Pharmaceuticals ... focused on discovering and developing innovative therapies primarily ... an update on the status of the Company,s ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ... 3,085 and 21 shares of Series A Preferred ...
(Date:5/26/2015)... WORMS, GERMANY – May 26, 2015 ... announces that its manufacturing facility in Worms, Germany ... EXCiPACTâ„¢, an independent organization that certifies manufacturers, suppliers, ... All three Grace facilities that produce its SYLOID® ... have now received GMP certification, following the Curtis ...
(Date:5/26/2015)... 26, 2015   Intrexon Corporation (NYSE: XON ... Gregory Frost , Ph.D., Senior Vice President and Head of ... Healthcare Conference on Wednesday, June 3 rd , at 1:30 ... New York City . About Intrexon Corporation ... the Bioindustrial Revolution with Better DNA ™ to create ...
(Date:5/26/2015)... 26, 2015   PDI , a leader ... that Oakwood Healthcare in Dearborn, Mich. ... entry in Delivering the Difference ... excellence in building collaborative relationships between infection prevention ... facilities.  Oakwood Healthcare,s infection preventionist, ...
Breaking Biology Technology:RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 2RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 3CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Intrexon to Present at the Jefferies 2015 Global Healthcare Conference 2PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3
... N.J., April 15 Quest Diagnostics,Incorporated (NYSE: ... of the,previously disclosed federal government investigation related to ... manufacturing subsidiary closed,voluntarily in 2006. Quest Diagnostics cooperated ... , Quest Diagnostics will ...
... announced today that it,has completed the formation of ... existing group of Senior Advisers. NexBio recently ... investigational drug,candidate for influenza. The new CAB will ... medicine, helping the company to conduct advanced,product development ...
... BELGIUM, Wis., April 15 Mach One Corporation ... company, announces Monte B. Tobin, the President and ... One,s shareholders:Dear Fellow Shareholders:The mission of Mach One ... global wellness organizations that provide bio-based solutions to ...
Cached Biology Technology:Quest Diagnostics Finalizes Previously Announced Settlement With Government Related to Test Kit Subsidiary Closed in 2006 2NexBio Completes Clinical Advisory Board for the Advanced Development of DAS181 (Fludase(R)*), a First-In-Class Medicine for Influenza 2NexBio Completes Clinical Advisory Board for the Advanced Development of DAS181 (Fludase(R)*), a First-In-Class Medicine for Influenza 3NexBio Completes Clinical Advisory Board for the Advanced Development of DAS181 (Fludase(R)*), a First-In-Class Medicine for Influenza 4Mach One CEO Letter to Shareholders 2Mach One CEO Letter to Shareholders 3Mach One CEO Letter to Shareholders 4
Buckets for tube holder inserts...
... spotting and preparation for MS analysis. ... can be accurately and continuously spotted onto ... solutions can be added automatically. This allows ... MALDI-TOF-MS measurements. By using it in conjunction ...
A camera based compact unit for high speed scanning of 2D barcoded tubes in a cluster rack. This reader has been designed to read both 96 and 48 tube rack configurations and be compatible with common...
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
Biology Products: