Navigation Links
Described a key mechanism in muscle regeneration
Date:12/19/2012

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have described a new selective target in muscle regeneration. This is the association of alpha-enolase protein and plasmin. The finding could be used to develop new treatments to regenerate muscular injuries or dystrophies. The study has been published in PLOS ONE journal.

Skeletal muscle has a great regeneration capacity after injury or genetic diseases such as Duchenne muscular dystrophy, the most common neuromuscular disorder in children. This condition is due to a defect in the gene of dystrophin, which absence causes instability of the membrane and leads to degeneration of muscle fibres.

Regeneration involves the restructuration of the muscular tissue and it requires the participation of extracellular enzymes such as plasmin. The alpha-enolase, an enzyme found in the cytoplasm of cells, enables the activity of plasmin on the cell membrane giving the cell the ability to degrade the surrounding tissue.

In this study, IDIBELL researchers show that the association of alpha-enolase and plasmin regulates two connected processes in the injured muscle or dystrophy: first, the attraction (recruitment) of immune cells to remove damaged tissue and, on the other hand, the formation of new muscle tissue from the stem cells. The researchers observed in the laboratory that these stem cells lost the ability to activate and merge to form skeletal muscle fibers when specific inhibitors of the alfa-enolasa/plasmina union were applied.

The researchers also performed experiments in mice with Duchenne muscular injury. When the animals were treated with the same inhibitors, mice showed a significant defect in muscle regeneration.

"These results demonstrate that the interaction of alpha-enolase and plasmin is necessary for the restoration of damaged muscle tissue", explained Roser Lpez-Alemany, IDIBELL researcher and study coordinator.

Recently, an extensive proteomic meta-analysis identified the alpha-enolase as the first differentially expressed protein in both human pathologies and mouse models, suggesting that "it may be considered a marker of a pathological stress in a large number of diseases", said Lopez-Alemany.


'/>"/>
Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. New species of deep-sea catshark described from the Galapagos
2. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
3. A mechanism providing clues for research into pancreatic diabetes is described
4. At least one-third of marine species remain undescribed
5. Scale-up of a temporary bioartificial liver support system described in BioResearch Open Access
6. Mechanism for Burgess Shale-type preservation
7. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
8. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
9. Researchers unravel genetic mechanism of fatty liver disease in obese children
10. Mechanism found connecting metastatic breast cancer and arthritis
11. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... August 23, 2017 , ... ... announced orders for advanced VPG+ 800 Volume Pattern Generators from two major Asian ... tomorrow’s demand for production of advanced photomasks as well as a solution for ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... built upon patented KBioBox technology, the extended GUIDE-Seq ananlysis. KBioBox has adapted their ... pipeline to be provide scientists with easy to understand reports, extended indel analysis, ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... its extensive experience with Health Economics and Outcomes Research (HEOR) and ‘big data’ ... In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent on ...
(Date:8/17/2017)... ... August 17, 2017 , ... CNA Finance Chief ... provided a research update on Aytu Bioscience and cited promising increases in the ... Soulstring, prescription rates for Natesto® have more than doubled since March of this ...
Breaking Biology Technology: