Navigation Links
Described a key mechanism in muscle regeneration
Date:12/19/2012

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have described a new selective target in muscle regeneration. This is the association of alpha-enolase protein and plasmin. The finding could be used to develop new treatments to regenerate muscular injuries or dystrophies. The study has been published in PLOS ONE journal.

Skeletal muscle has a great regeneration capacity after injury or genetic diseases such as Duchenne muscular dystrophy, the most common neuromuscular disorder in children. This condition is due to a defect in the gene of dystrophin, which absence causes instability of the membrane and leads to degeneration of muscle fibres.

Regeneration involves the restructuration of the muscular tissue and it requires the participation of extracellular enzymes such as plasmin. The alpha-enolase, an enzyme found in the cytoplasm of cells, enables the activity of plasmin on the cell membrane giving the cell the ability to degrade the surrounding tissue.

In this study, IDIBELL researchers show that the association of alpha-enolase and plasmin regulates two connected processes in the injured muscle or dystrophy: first, the attraction (recruitment) of immune cells to remove damaged tissue and, on the other hand, the formation of new muscle tissue from the stem cells. The researchers observed in the laboratory that these stem cells lost the ability to activate and merge to form skeletal muscle fibers when specific inhibitors of the alfa-enolasa/plasmina union were applied.

The researchers also performed experiments in mice with Duchenne muscular injury. When the animals were treated with the same inhibitors, mice showed a significant defect in muscle regeneration.

"These results demonstrate that the interaction of alpha-enolase and plasmin is necessary for the restoration of damaged muscle tissue", explained Roser Lpez-Alemany, IDIBELL researcher and study coordinator.

Recently, an extensive proteomic meta-analysis identified the alpha-enolase as the first differentially expressed protein in both human pathologies and mouse models, suggesting that "it may be considered a marker of a pathological stress in a large number of diseases", said Lopez-Alemany.


'/>"/>
Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. New species of deep-sea catshark described from the Galapagos
2. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
3. A mechanism providing clues for research into pancreatic diabetes is described
4. At least one-third of marine species remain undescribed
5. Scale-up of a temporary bioartificial liver support system described in BioResearch Open Access
6. Mechanism for Burgess Shale-type preservation
7. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
8. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
9. Researchers unravel genetic mechanism of fatty liver disease in obese children
10. Mechanism found connecting metastatic breast cancer and arthritis
11. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... -- News solutions for biometrics, bag drop and New ... At ... 16 March, Materna will present its complete end-to-end passenger journey, ... a real benefit for passengers. To accelerate the whole passenger ... point solutions to take passengers through the complete integrated process ...
(Date:2/22/2017)... With the biometrics market to exceed ... technologies that innovative and agile startups must incorporate ... the changing competitive landscape: multifactor authentication (MFA), point-of-sale ... "Companies can no longer afford to cut ... Dimitrios Pavlakis , Industry Analyst at ABI Research. ...
(Date:2/13/2017)... 13, 2017  RSA Conference -- RSA, a Dell ... designed to enhance fraud detection and investigation across ... RSA Fraud & Risk Intelligence Suite. The new ... additional insights from internal and external sources as ... their customers from targeted cybercrime attacks. ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... YORK , March 23, 2017 ... ... of death, putting significant strain on health care systems, in ... cancer diagnoses rises, so too does the development of innovative ... minimum side effects. Among the many types of cancer treatments, ...
(Date:3/23/2017)... March 23, 2017 In today,s ... equities in the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: ... (NYSE MKT: SYN), and Regulus Therapeutics Inc. (NASDAQ: ... 2017, Credit Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market ... free report at: ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... up human tissue regeneration from small lab samples to full-size tissues, bones, even ... to establish a vascular system that delivers blood deep into the developing tissue. ...
(Date:3/22/2017)... 2017 Good Start Genetics, a leading family ... 130 million covered lives mark through its most recent ... Texas . With newly signed contracts nationally and ... strong payor acceptance based on the quality of its ... counseling, its industry-leading customer care and support and its ...
Breaking Biology Technology: