Navigation Links
Described a key mechanism in muscle regeneration
Date:12/19/2012

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have described a new selective target in muscle regeneration. This is the association of alpha-enolase protein and plasmin. The finding could be used to develop new treatments to regenerate muscular injuries or dystrophies. The study has been published in PLOS ONE journal.

Skeletal muscle has a great regeneration capacity after injury or genetic diseases such as Duchenne muscular dystrophy, the most common neuromuscular disorder in children. This condition is due to a defect in the gene of dystrophin, which absence causes instability of the membrane and leads to degeneration of muscle fibres.

Regeneration involves the restructuration of the muscular tissue and it requires the participation of extracellular enzymes such as plasmin. The alpha-enolase, an enzyme found in the cytoplasm of cells, enables the activity of plasmin on the cell membrane giving the cell the ability to degrade the surrounding tissue.

In this study, IDIBELL researchers show that the association of alpha-enolase and plasmin regulates two connected processes in the injured muscle or dystrophy: first, the attraction (recruitment) of immune cells to remove damaged tissue and, on the other hand, the formation of new muscle tissue from the stem cells. The researchers observed in the laboratory that these stem cells lost the ability to activate and merge to form skeletal muscle fibers when specific inhibitors of the alfa-enolasa/plasmina union were applied.

The researchers also performed experiments in mice with Duchenne muscular injury. When the animals were treated with the same inhibitors, mice showed a significant defect in muscle regeneration.

"These results demonstrate that the interaction of alpha-enolase and plasmin is necessary for the restoration of damaged muscle tissue", explained Roser Lpez-Alemany, IDIBELL researcher and study coordinator.

Recently, an extensive proteomic meta-analysis identified the alpha-enolase as the first differentially expressed protein in both human pathologies and mouse models, suggesting that "it may be considered a marker of a pathological stress in a large number of diseases", said Lopez-Alemany.


'/>"/>
Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. New species of deep-sea catshark described from the Galapagos
2. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
3. A mechanism providing clues for research into pancreatic diabetes is described
4. At least one-third of marine species remain undescribed
5. Scale-up of a temporary bioartificial liver support system described in BioResearch Open Access
6. Mechanism for Burgess Shale-type preservation
7. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
8. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
9. Researchers unravel genetic mechanism of fatty liver disease in obese children
10. Mechanism found connecting metastatic breast cancer and arthritis
11. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... ISTANBUL , June 9, 2016  Perkotek an innovation leader in attendance control ... to seamlessly log work hours, for employers to make sure the right employees are ... Logo - http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/24/2016)... 2016 Ampronix facilitates superior patient care by providing unparalleled technology to leaders ... is the latest premium product recently added to the range of products distributed by ... ... ... LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining ... Chicago. The result of a collaboration among several companies with expertise in toolholding, ...
(Date:6/22/2016)... DUBLIN , June 22, 2016 Research ... and Global Markets" report to their offering. ... $39.4 billion in 2014 from $29.3 billion in 2013. The market ... (CAGR) of 13.8% from 2015 to 2020, increasing from $50.6 billion ... and projected product forecasts during the forecast period (2015 to 2020) ...
(Date:6/22/2016)... SAN DIEGO , June 22, 2016   ... the first pluripotent stem cell-derived islet replacement therapy for ... two presentations at ISSCR 2016 Annual Meeting.  ISSCR 2016, ... 22nd to 25th at Moscone West in San Francisco.  ... Details of the presentations are as follows:Event: , Focus ...
Breaking Biology Technology: