Navigation Links
Depression associated with sustained brain signals
Date:4/5/2010

Depression and schizophrenia can be triggered by environmental stimuli and often occur in response to stressful life events. However, some people have a higher predisposition to develop these diseases, which highlights a role for genetics in determining a person's disease risk. A high number of people with depression have a genetic change that alters a protein that cells use to talk to each other in the brain. Imaging of people with depression also shows that they have greater activity in some areas of their brain. Unfortunately, the techniques that are currently available have not been able to determine why stress induces pathological changes for some people and how their genetics contribute to disease.

A new mouse model may provide some clues about what makes some people more likely to develop depression after experiencing stress. A collaborative group of European researchers created a mouse that carries a genetic change associated with depression in people. "This model has good validity for understanding depression in the human, in particularly in cases of stress-induced depression, which is a fairly widespread phenomenon" says Dr. Alessandro Bartolomucci, the first author of the research published in the journal, Disease Models and Mechanisms (DMM).

The scientists made genetic changes in the transporter that moves a signaling protein, serotonin, out of the communication space between neurons in the brain. The changes they made are reminiscent of the genetic changes found in people who have a high risk of developing depression.

"There is a clear relationship between a short form of the serotonin transporter and a very high vulnerability to develop clinical depression when people are exposed to increasing levels of stressful life events." says Dr. Bartolomucci, "This is one of the first studies performed in mice that only have about 50% of the normal activity of the transporter relative to normal mice, which is exactly t
'/>"/>

Contact: Kristy Kain
kristy.kain@vanderbilt.edu
858-752-7877
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mental health providers should prescribe exercise more often for depression, anxiety
2. Early abuse tied to more depression in children
3. Targacepts P.2b depression study succeeds: 6-point difference on HAM-D
4. Mediterranean diet associated with reduced risk of depression
5. Depression and anxiety disorders of adolescents are not the same thing
6. Genetic factors may predict depression in heart disease patients
7. Team identifies a molecular switch linking infectious disease and depression
8. Mothers of multiple births at increased odds of postpartum depression
9. Researchers take first look at the genetic dynamics of inbreeding depression
10. Children seriously affected when a parent suffers from depression
11. Chantix side effects no worse with depression history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Va. , Dec. 15, 2014 ... to make it easier to detect and prevent ... Today the agency started performing an ... capability will validate the authenticity of purchased microcircuits ... The new quality control measures will be conducted ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... WINSTON SALEM, N.C. , Dec. 10, 2014  That ... known for quite a while. Hypertension – the medical term ... disease in the early 1800s, and the inflatable cuff that,s ... That doesn,t, however, mean there,s nothing new about hypertension, ... punctured some long-held beliefs about the condition and the best ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... of funding-- dollars drop, in this particular case, for ... faculty and staff. Those declines ultimately impact student ... "Obviously if you,ve had a 30% reduction in funding, ... budget. And so programs are affected," says Colorado ...
... − A new study from the Infant Brain Imaging ... Research at the Children,s Hospital of Philadelphia (CHOP), found ... months in high-risk infants who later develop autism, compared ... "It,s a tremendously exciting finding," said Sarah Paterson, PhD, ...
... SEATTLE Evolutionary biologist Harmit Singh Malik, Ph.D., of ... grant from the Lupus Research Institute to study the ... lupus, an autoimmune disease. , Malik and colleagues want ... causes lupus autoimmunity., "We want to determine whether autoimmunity ...
Cached Biology News:New autism research reveals brain differences at 6 months in infants who develop autism 2Did an evolutionary arms race cause lupus? Biologist Harmit Malik receives grant to try and find out 2
(Date:12/19/2014)... Tigard, OR and Hershey, PA (PRWEB) December 19, ... (OTC Pink: BJCT), a leading developer and manufacturer ... has entered into an agreement with Immunomic Therapeutics, ... Bioject’s Biojector®-2000 needle-free injection device with its LAMP™ ... receives an option for an exclusive Worldwide license ...
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... 19, 2014 BioPlus Specialty Pharmacy ... announces the promotion of Nick Maroulis, Pharm.D. to the ... Services. , In this position, Dr. Maroulis will ... managing the directors of our multi-site pharmacies as the ... 1997 and during that time he has served in ...
(Date:12/19/2014)... Ill. , Dec. 19, 2014 Naurex ... develop novel drugs for diseases of the central nervous ... president and chief executive officer, will present at the ... Riedel,s presentation will take place at 3:00 p.m. PST ... Francis in San Francisco, Calif. ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... Beckman Coulter,Inc. (NYSE: BEC ), a ... automate, and innovate complex biomedical testing,announced today that ... Business Development, will present at the following,conferences:, ... -- Bank of America 2008 Healthcare Conference on ...
... in physician,s office -, MADISON, N.J., May ... Diagnostics Incorporated (NYSE: DGX ),today announced the ... fecal,immunochemical test, a point-of-care version of the company,s ... sensitivity and,specificity of the laboratory-based InSure FIT test., ...
... CE Mark Approval for First Product, the CorMatrix ... ECM(TM) for Pericardial ... based company dedicated to developing and delivering unique,extracellular matrix (ECM(TM)) ... cardiovascular tissue, announced,today that the company has received 510(k) clearance ...
Cached Biology Technology:Beckman Coulter to Present at Upcoming Healthcare Conferences 2Enterix Inc. Launches Its Point-of-Care Test for Colorectal Cancer Screening 2Enterix Inc. Launches Its Point-of-Care Test for Colorectal Cancer Screening 3Enterix Inc. Launches Its Point-of-Care Test for Colorectal Cancer Screening 4Enterix Inc. Launches Its Point-of-Care Test for Colorectal Cancer Screening 5CorMatrix(R) Announces FDA 510(k) for Novel Biomaterial Implant for Intracardiac Repair 2CorMatrix(R) Announces FDA 510(k) for Novel Biomaterial Implant for Intracardiac Repair 3CorMatrix(R) Announces FDA 510(k) for Novel Biomaterial Implant for Intracardiac Repair 4
Rabbit polyclonal to Shigella Immunogen: Mixture of S. boydii, S. flexneri & S. dysenteriae....
... instrument engineered to match the speed of ... of research centers worldwide. It uses 1.5 ... ideally suited for high-speed temperature cycling due ... surface-area-to-volume ratio. ,By combining glass capillary tubes ...
... CUL-3 is a member of the family of human ... homologous to the S. cerevisiae cdc53 gene. Cullin-3 is ... It forms a tight complex with cyclin E and ... by protesomes. Cyclin E is an activator of cdk2, ...
Yellow oily liquid. Contains 85% Drakeol 5NF, 15% Arlacel A (mannide monooleate emulsifier). Heat sterilized. Contains zero colony forming units/ml. ...
Biology Products: