Navigation Links
Depressed mice could aid research on drug-resistant depression in humans
Date:6/29/2010

ession. "About 70 percent of people who are treated for depression also are treated for anxiety at some time during their lives, and the drugs that are used in people as antidepressants act not only to reduce depression but also to reduce anxiety," Luscher said. "These facts suggests that whatever mechanism is defective in the brain is similar in both anxiety and depression."

One of the interesting results of Luscher's new research is that some antidepressant drugs completely reverse the behavioral and hormonal symptoms of depression in the GABA-A-receptor-deficient mice, bringing their behavior to the level of normal, "wild-type" mice. At the same time, the normal mice had almost no reaction to the drugs. "This result is expected of a mouse model that mimics depression because normal people do not seem to gain anything from taking antidepressants," Luscher explained. These experiments show that this strain of genetically defective mice is a useful animal model for laboratory studies that could be useful for understanding human depression.

One of the major gaps of knowledge about depression in humans is that scientists do not know why some antidepressant drugs fail to help about 30 percent of depressed patients. Because doctors don't have a way of knowing which drug has the best chance of working for a particular patient, they resort to trying one after another hoping to find one that will work. This problem is compounded by the fact that it can take weeks before the drugs show any measurable benefit.

Luscher's team tested two kinds of antidepressant drugs in the mice and found that one of the drugs reduced symptoms of anxiety, but not of depression, whereas the other drug reduced both anxiety and depression symptoms. "The one that did not normalize depression-related behaviors is fluoxetine -- the generic name for Prozac -- which works on the neurotransmitter serotonin," Luscher said. The drug that reduced both depression and anx
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Women more depressed and men more impulsive with reduced serotonin functioning
2. New tracking tags are providing fish-eye views of ways to manage depressed fisheries
3. Pre-pregnancy depressed mood may heighten risk for premature birth
4. Newly created cancer stem cells could aid breast cancer research
5. Obesity and lack of exercise could enhance the risk of pancreatic cancer
6. Finding that 1-in-a-billion that could lead to disease
7. 60 second test could help early diagnosis of common brain diseases
8. Auto immune response creates barrier to fertility; could be a step in speciation
9. Paracetamol, one of most used analgesics, could slow down bone growth
10. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
11. Thousands of starving children could be restored to health with peanut butter program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Depressed mice could aid research on drug-resistant depression in humans
(Date:3/20/2015)... 20, 2015 Research and Markets ... the "India Sensors Market Forecast and Opportunities ... The sensor market is projected to grow at ... Consumer electronics, automotive, industrial and healthcare sectors are ... country. In addition, adoption of MEMS technology in ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
(Date:3/17/2015)... , March 17, 2015 MedNet ... specializing in clinical study management systems, is pleased ... attendance at ARENA,s Outsourcing in Clinical Trials Southeast ... event provides an excellent forum for MedNet to ... and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... we knowfor sure. Adding to a growing literature ... sperm ,function, it is now shown that one lactate dehydrogenase ... of ,work on this glycolytic enzyme had shown that it ... been ,only speculative. In an article on p. 26 Odet ...
... spring apples from the southern hemisphere as they enter the ... that has swept the industrialized world over the past couple ... complicated global process that has changed every aspect of how ... supermarkets in a country should bring with it the "cheap ...
... into the mechanisms that underlie long-term memory research with ... "The more we know about how long-term memory is ... in the brain, the more we are going to be ... professor of physiological science and neurobiology, whose new research appears ...
Cached Biology News:July 2008 highlights 2Lost in the supermarket? 2Study of marine snail leads to new insights into long-term memory 2Study of marine snail leads to new insights into long-term memory 3Study of marine snail leads to new insights into long-term memory 4
(Date:4/16/2015)... Spirax Sarco, the leader in ... newly designed, state-of-the-art website in the first quarter ... promotes the Spirax Sarco brand, company capabilities, and ... a site visitor might be looking for including ... serviced, the latest company news, careers, and much ...
(Date:4/16/2015)... FL (PRWEB) April 16, 2015 ... cap distribution and physician network in Europe and ... company has appointed Fernando Bermúdez, former Business Development ... , An industry veteran, Mr. Bermúdez’s professional achievements ... 75% in Spain, while also penetrating the Portuguese ...
(Date:4/16/2015)... Streetsboro, Ohio (PRWEB) April 16, 2015 ... Safety Index, overexertion involving an outside source was ... injuries. This includes injuries related to lifting, pushing, ... $15.1 billion in direct costs. The David Round ... Round is committed to working hard to develop ...
(Date:4/16/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company" ... pleased to announce that the Company will be presenting ... to be held in London, UK ... Mr. James Mellon , a director of Portage, ... key programs at its subsidiaries, Portage Pharmaceuticals Ltd. ("PPL"), ...
Breaking Biology Technology:Spirax Sarco website has a new look 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... new data and program updates on cancer stem cell targeting ... ... /PRNewswire-FirstCall/ - ARIUS Research Inc., (TSX:,ARI), a biotechnology company discovering and ... be presenting new,findings and program updates related to its CD44, TROP-2, ...
... Ltd.,(SWX: ARPN) today announced that it will host ... 8.30am CET. In this conference call, a leading ... the area of anti-infective,drugs as well as the ... Advisory Committee. During that meeting, the committee discussed,product ...
... Chairman & CEO, Paul Willis,stated, "Just like his ... Whitacre has risen fast at Cypress Systems, Inc, last ... of operations.",Now Cypress and Whitacre are focusing their energy ... Americans -- and people around the,world -- to consume ...
Cached Biology Technology:ARIUS presents new findings for anti-cancer antibody programs at AACR 2ARIUS presents new findings for anti-cancer antibody programs at AACR 3ARIUS presents new findings for anti-cancer antibody programs at AACR 4ARIUS presents new findings for anti-cancer antibody programs at AACR 5Arpida Announces Conference Call on 17 April 2Arpida Announces Conference Call on 17 April 3Cypress Systems, Inc. Launches Cancer Prevention Health Campaign Using SelenoExcell(R) 2Cypress Systems, Inc. Launches Cancer Prevention Health Campaign Using SelenoExcell(R) 3