Navigation Links
Depressed mice could aid research on drug-resistant depression in humans
Date:6/29/2010

New research shows that a unique strain of laboratory mice characterized at Penn State University has behavioral, hormonal, and neurochemical characteristics that are similar to those of human patients with drug-resistant forms of depression. The mice -- which have a defect in a gene -- are expected to be useful as a new model organism in the effort to develop more effective medications for specific forms of depression. The research, led by Bernhard Luscher, a professor of biology at Penn State, will be published in the journal Biological Psychiatry.

"A mouse can't tell us if it is feeling depressed, so we used a number of different kinds of tests -- including some new ones that we developed -- to gauge behavioral and hormonal changes, or phenotypes, of a type of depression that, in humans, does not respond well to some antidepressant drugs," Luscher said. "These indicators include reduced exploration of novel or otherwise aversive environments, failure to escape from a highly stressful situation, and reduced pleasure-seeking behavior such as a reduced preference for sweet over plain water."

The genetic defect in the depressed mice interferes with the function of a protein in the brain called the GABA-A receptor, which controls the response to the neurotransmitter gamma-aminobutryic acid. Reduced function of these receptors has been known to be be involved in anxiety disorders -- but not in depression -- because currently available drugs that activate the GABA-A receptor are ineffective as antidepressants. "We have shown in this paper that this long-held conviction is flawed," Luscher said. "Our research shows that the GABA-A receptor is, in fact, an important part of the brain circuitry that is not working properly in depression."

The genetically defective, GABA-A-receptor-deficient mice in Luscher's lab previously had been shown to be a good model organism for studies of anxiety, which often occurs along with depr
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Women more depressed and men more impulsive with reduced serotonin functioning
2. New tracking tags are providing fish-eye views of ways to manage depressed fisheries
3. Pre-pregnancy depressed mood may heighten risk for premature birth
4. Newly created cancer stem cells could aid breast cancer research
5. Obesity and lack of exercise could enhance the risk of pancreatic cancer
6. Finding that 1-in-a-billion that could lead to disease
7. 60 second test could help early diagnosis of common brain diseases
8. Auto immune response creates barrier to fertility; could be a step in speciation
9. Paracetamol, one of most used analgesics, could slow down bone growth
10. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
11. Thousands of starving children could be restored to health with peanut butter program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Depressed mice could aid research on drug-resistant depression in humans
(Date:9/23/2014)... California , 23 de septiembre de ... lanzamiento del Sistema 1290 Infinity II LC, ... de Infinity en su portafolio de cromatografía ... científicos y directores de laboratorio que alcancen ... excepcional, facilidad de uso y capacidad de ...
(Date:9/22/2014)... A new American Cancer Society study suggests that ... previously known as the food stamp program, had ... non-participants. The authors say the findings emphasize the ... dietary quality of SNAP participants. , The SNAP ... with the resources to obtain a nutritionally adequate ...
(Date:9/22/2014)... also known as tapioca, has large starch-filled roots and ... Asia, and Latin America where corn and sugarcane are ... and processes designed to break down tapioca starch into ... such as glucose, fructose, or maltose syrup, tapioca may ... a Review article in Industrial Biotechnology , a ...
Breaking Biology News(10 mins):Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 2Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 3Federal food program puts food on the table, but dietary quality could be improved 2
... menstruating have a weakening in the quality of their bone ... getting plenty of weight-bearing exercise, a new study finds. The ... Annual Meeting in Boston. "Given the high number of ... fact that up to 24% of young female athletes may ...
... Using the only microscope of its kind in Australia, ... see the inner workings of T-cells, the front-line troops that ... germs and other invaders in our bloodstream. The discovery ... T-cells into action a breakthrough that could lead to ...
... 2011 The International Development Research Centre (IDRC) together with ... Sciences and Engineering Research Council of Canada (NSERC), and ... (SSHRC) today announce that five research teams have been ... International Research Initiative on Adaptation to Climate Change (IRIACC). ...
Cached Biology News:Athletic girls more likely to have impaired bone structure if menstrual cycle stops 2Scientists use super microscope to pinpoint body’s immunity 'switch' 2International research initiative on adaptation to climate change announces research awards 2International research initiative on adaptation to climate change announces research awards 3
(Date:9/23/2014)... Sept. 23, 2014 News Facts ... India devoted to genome-based research for human health ... is taking a bite out of oral cancer with ... in India with the help of ... DataDirect Networks (DDN). , To fuel its cutting-edge cancer ...
(Date:9/23/2014)... , September 23, 2014 ... Closed System Transfer     Devices  (CSTD) ... partnership with Taiwanese distributor MedFront Medical Technology Corporation.  Equashield,s leading ... Taiwan , China ... the company continues to expand globally, and throughout ...
(Date:9/23/2014)... 2014 The Minnesota High Tech ... cellular modems , platforms and application-specific remote ... category for the 2014 Tekne Awards. The ... Minneapolis Convention Center on Thursday, November 13th. The ... have shown superior technology innovation and leadership. ...
(Date:9/22/2014)... DUBLIN , September 22, 2014 ... has announced the addition of the "Global ... offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... are added to a system to detect and ... Reagents are generally used in laboratories to prepare, ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3
... Oconomowoc-based IT services provider, announced Tuesday a new market ... July 1, the campaign will expand the PDS presence ... recently received Specialized Technology Partner Certifications from Cisco in ... partner; IP Communications, IP Communications Express, and Wireless. In ...
... When Hurricane Dennis reached landfall in the Florida ... surprising a development. Weather Central Inc. , a ... almost the exact location two days earlier. , ,On ... a service used by more than 100 television stations ...
... incubates a branding process, which can result in a random ... extreme name identity, whereupon a major advertising process kicks in. ... that's how we refer to today's trendy branding. To avoid ... various branding tricks and become aware of the bigger risks. ...
Cached Biology Technology:Accidental naming 2Accidental naming 3Accidental naming 4
ANXA11 Immunogen: ANXA11 (NP_001148, 406 a.a. ~ 506 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Anti-ADAM-12 (Meltrin Alpha); carboxy terminal end; rabbit host...
Anti-Flavocytochrome b Monoclonal, FITC Labeled Research Focus: other Storage: 4C Shipping Temperature: 4C...
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
Biology Products: