Navigation Links
Dendritic cell therapy improves kidney transplant survival, Pitt team says
Date:6/28/2013

roup of monkeys was transplanted without receiving the cells, but both groups were given the same regimen of immunosuppression drugs, a modified protocol for experimental purposes that eventually results in donor organ rejection. The researchers found that the donor kidney was rejected in about 40 days among animals that got only the drugs, but survived for about 113 days in the group that had a prior infusion of treated DCs.

The modified donor DCs sent signals to the recipient immune system to stay quiet and not launch an attack against the donor organ, explained lead author Mohamed Ezzelerab, M.D., research assistant professor, Department of Surgery, Pitt School of Medicine.

"The results indicate that we achieved immune system regulation without side effects of the DCs, but better yet, the monkeys were healthier from a clinical perspective," he said. "They maintained a better weight, had less protein in the urine and fewer signs of kidney damage than the other group. Ultimately, all these factors played a role in prolonging organ survival in the group that received DC therapy."


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. No danger of cancer through gene therapy virus
2. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
3. New sickle cell anemia therapy advances to Phase II clinical trials
4. Posttraumatic stress disorder treatment: Genetic predictor of response to exposure therapy
5. Mount Sinai discovers new liver cell for cellular therapy to aid in liver regeneration
6. New Research: Modified Citrus Pectin - A Potent Anti-Cancer Therapy
7. Researchers reveal new more precise method of performing electroconvulsive therapy
8. Discovery may help prevent chemotherapy-induced anemia
9. Penn receives prestigious national award for breakthrough in gene therapy
10. Icy therapy spot treats cancer in the lung
11. New therapy for fragile X chromosome syndrome discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... cheating in science are among the topics to ... experts in Montreal at the three International Union ... to August 1, 2014. Some 2,000 participants from ... 14th International Congress of Bacteriology and Applied Microbiology, ... Microbiology, and the 16th International Congress of Virology. ...
(Date:7/21/2014)... in areas across Riau province on Sunday, July 20, ... a decline in rainfall. The number of detected ... had been reported one day prior, which had reached ... six regencies and municipalities, most of which were in ... it creates could potentially spread via winds to Malaysia ...
(Date:7/21/2014)... that uses extracts from seeds of Moringa oleifa trees ... 90% to 99%. The hardy trees that are drought ... Asia, and Latin America. , The protocol, which is ... review, is low-cost and efficient, making it especially useful ... who are presently drinking highly turbid and contaminated water. ...
Breaking Biology News(10 mins):Montreal hosts International Union of Microbiology Societies congresses 2
... must address ecological threats, a top international scientific meeting ... the planet,s natural limits in a striking parallel to ... a subprime loan," Dr. Johan Rockstrm of the Stockholm ... risks of both kinds of crises in the future. ...
... a multi-year $1 million sponsored research agreement with ... the maker of Smart Balance buttery spread and ... cholesterol through a patented blend of natural vegetable ... entered into a collaboration and license to develop ...
... 6, 2008, Cambridge, UK ,Discussion of a man,s background, ... and The City episodes in the future, it could ... Risk of developing type 2 diabetes and metabolic ... this background has in turn been influenced by environment and ...
Cached Biology News:Top scientific meeting urges coordinated response to economic and environmental crises 2Brandeis and Smart Balance team up to advance heart-healthy research 2Coping and copulation behavior may help calculate diabetes risk 2
(Date:7/21/2014)... of Arts and Sciences has received a major ... , Mathew M. Maye, associate professor of chemistry, ... the National Science Foundation (NSF). The award supports ... the results of which may impact gas storage, ... , Maye,s approach is novel, in that he ...
(Date:7/21/2014)... , July 21, 2014  Mike Patterson, CEO ... $1.6 million in Series Seed B funding to ... sensors for the life science, defense, intelligence, and ... Partners led the round and was joined by ... Said Patterson , "This round of funding ...
(Date:7/21/2014)... (PRWEB) July 21, 2014 Sleep ... quality are closely correlated with depression. According to ... Health: "About three quarters of depressed patients ... about 40% of young depressed adults and 10% ... The symptoms cause huge distress, have a major ...
(Date:7/20/2014)... (PRWEB) July 20, 2014 NSG ... quartz glass optics, and spectrophotometer calibration ... years, NSG has released many products that have ... product has been their solid-state calibration standards. , ... standards since their release in 2008. NSG ...
Breaking Biology Technology:Syracuse University chemist to use NSF grant to study materials chemistry, nanoscience 2Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 3How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 3
... Switzerland, May 16 Arpida Ltd.,(SWX: ARPN) today announced ... for review the New Drug Application (NDA) for,intravenous iclaprim ... (cSSSI). Arpida completed the submission of the NDA to,the ... ten month review to,the iclaprim NDA and has established ...
... Million - ... - Gross Profit Up; Net Loss Down -, TUSTIN, ... a vertically integrated specialty pharmaceutical company headquartered,in Tustin, California, with ... subsidiary Jade Pharmaceutical Inc. (JPI),the Company engages in the research, ...
... Principle Reached to Terminate Marketing Agreement with Triax ... on Most Favorable Terms, NAPA, Calif., May 15 ... company engaged in the development,of technologies that target the ... quarter ended March 31, 2008 and an agreement in,principle ...
Cached Biology Technology:Arpida Announces FDA Acceptance of the Iclaprim New Drug Application 2Arpida Announces FDA Acceptance of the Iclaprim New Drug Application 3AMDL Announces First Quarter 2008 Results Posting Sales of $3.58 Million 2AMDL Announces First Quarter 2008 Results Posting Sales of $3.58 Million 3Senetek PLC Reports First Quarter 2008 Financial Results 2Senetek PLC Reports First Quarter 2008 Financial Results 3
... Conjugated peptides or recombinant proteins are used ... antibodies in 2 rabbits. pre-immune and three ... until the titer reaches 1:4,000 Western blot ... G purification Antibodies are eluted using both ...
... analysis & visualization software. ... multiple samples. Combine Sequest ... increased confidence. Get more ... from your MS/MS experiments.14 ...
TRIzol Reagents are ready-to-use monophasic solutions of phenol and guanidine isothiocyanate suitable for isolating total RNA DNA and proteins (16)....
...
Biology Products: