Navigation Links
Dendritic cell therapy improves kidney transplant survival, Pitt team says
Date:6/28/2013

PITTSBURGH, June 28, 2013 -- A single systemic dose of special immune cells prevented rejection for almost four months in a preclinical animal model of kidney transplantation, according to experts at the University of Pittsburgh School of Medicine. Their findings, now available in the online version of the American Journal of Transplantation, could lay the foundation for eventual human trials of the technique.

Organ transplantation has saved many lives, but at the cost of sometimes lifelong requirements for powerful immunosuppressive medication that can have serious side effects, said senior investigator Angus Thomson, Ph.D., D.Sc., distinguished professor of surgery and of immunology, Pitt School of Medicine. Scientists have long sought ways to encourage the organ recipient's immune system to accept or tolerate the donor organ to reduce the need for drugs to stave off rejection.

"This study shows it is possible to prepare the patient's immune system for a donor kidney by administering specially treated immune cells from the donor in advance of the transplant surgery," Dr. Thomson said. "This could be very helpful in the context of planned kidney donations from living relatives, and could one day be adapted to transplantation from deceased donors."

For the project, the research team generated immune cells called dendritic cells (DCs) from the blood of rhesus macaques that would later provide a kidney to recipient monkeys. Dendritic cells are known to be key regulators of the immune system by showing antigens to T-cells to either activate them against the foreign protein or to suppress the T-cell response. The researchers treated the donor DCs in the lab to prevent them from fully maturing and having the capacity to trigger an immune reaction against foreign proteins.

One week before having a kidney transplant, recipient monkeys received a single infusion of treated DCs obtained from their respective donor animals. Another g
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. No danger of cancer through gene therapy virus
2. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
3. New sickle cell anemia therapy advances to Phase II clinical trials
4. Posttraumatic stress disorder treatment: Genetic predictor of response to exposure therapy
5. Mount Sinai discovers new liver cell for cellular therapy to aid in liver regeneration
6. New Research: Modified Citrus Pectin - A Potent Anti-Cancer Therapy
7. Researchers reveal new more precise method of performing electroconvulsive therapy
8. Discovery may help prevent chemotherapy-induced anemia
9. Penn receives prestigious national award for breakthrough in gene therapy
10. Icy therapy spot treats cancer in the lung
11. New therapy for fragile X chromosome syndrome discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014 Biometrics ... and innovative smart technologies; companies turn towards digital currency: ... EBAY ), Amazon.com Inc. (NASDAQ: AMZN ), ... (NASDAQ: GOOG ) and Microsoft Corporation (NASDAQ: ... focused on the growing m-commerce market, announces a video ...
(Date:7/31/2014)... nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine ... online publications, British Medical Journal Open (BMJ Open) ... BMJ Open article looked at the effects ... showed that tree nut consumption resulted in a significant ... PLOS ONE article focused on the effect of ...
(Date:7/30/2014)... Inspired by the Red Queen in Lewis Carroll,s ... of Illinois and National University of Singapore improved ... species evolve over decades to millions of years. ... model for competition, incorporates the "Red Queen Effect," ... in the 1970s, which suggests that organisms must ...
Breaking Biology News(10 mins):Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3
... multi-disciplinary analysis that included cognitive, neurophysiologic, virologic, and molecular ... in the brain and immune cells that had infiltrated ... , "As in the rest of the body, ... control of the virus, but are unable to clear ...
... genes to survive than scientists first believed, according to new ... some of the simplest forms of life and have been ... genes ?or minimal genome ?that is needed for maintaining life. ... 'knocking out', a series of individual genes from a bacterial ...
... scientists have found that people have an ancient skeleton ... a jawless, eel-like fish. , It turns out lampreys, ... than almost all other backboned animals, may not be ... genetics that govern their skeletal development, according to findings ...
Cached Biology News:Immune response to HIV in the brain 2Minimal genome should be twice the size, study shows 2Minimal genome should be twice the size, study shows 3UF scientists reveal ancient origin of vertebrate skeleton 2UF scientists reveal ancient origin of vertebrate skeleton 3
(Date:7/31/2014)... July 31, 2014 Nearly 20,000 medical professionals ... Annual Meeting & Clinical Lab Expo in ... never-before-seen breakthroughs in diagnostic research and technology that will ... As of Wednesday, July 30, more than ... Meeting & Clinical Lab Expo, with more than 10,000 ...
(Date:7/31/2014)... Researchers at Johns Hopkins have mapped the sound-processing part ... both the proverbial forest and the trees in view. ... views of brain activity within mice, and it enabled ... mice "called" to each other. The results, which represent ... process language, appear online July 31 the journal ...
(Date:7/31/2014)... PORTOLA VALLEY, Calif. , July 31, 2014 /PRNewswire/ ... San Francisco Bay Area , has ... the University of Oxford,s commercialisation company. The potent anti-inflammatory ... David Greaves at the University of Oxford,s Sir ... The company, which has raised over $1.5 million ...
(Date:7/31/2014)... Research and Markets has announced ... report to their offering. ... of the genetic material or genomes of an organism. ... the discovery and development of diagnostic and therapeutic solutions ... Genomics is supported by three major product segments: Instruments, ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... China, Oct. 14 /Xinhua-PRNewswire/ -- WuXi PharmaTech,(Cayman) Inc. ... and,medical device research and development outsourcing company with ... the addition of Jeff X.,Leng, managing director of ... Mr. Leng is replacing Sean Tong, formerly with ...
... and III ... Trials, ... ) today announced positive long-term follow-up,data from the CUSTOM I, II and ... stent (DES) system in treating,patients with coronary artery disease. The CUSTOM clinical ...
... SEATTLE, Oct. 13 Larry Corey, M.D., senior ... Disease Institute,at Fred Hutchinson Cancer Research Center, today ... the prestigious Institutes of Medicine (IOM)., Election ... highest honors in the,fields of health and medicine ...
Cached Biology Technology:WuXi PharmaTech Appoints Jeff Leng to Its Board of Directors 2Custom NX(R) Drug Eluting Stent System Continues to Demonstrate Favorable Outcomes in Challenging Patient Populations at One, Two and Three Years 2Custom NX(R) Drug Eluting Stent System Continues to Demonstrate Favorable Outcomes in Challenging Patient Populations at One, Two and Three Years 3
Hamster serum...
... Kit with CyScribe GFX Purification Kit, ... purification of Cy3- and Cy5-labeled cDNA.Optimized ... cDNA labeling and purification.Flexible and optimized ... labeling reactions with either Cy3- or ...
Canine Serum...
CASPR (H-66)...
Biology Products: