Navigation Links
Delving into the molecular mechanism behind deep-sea bacteria's pressure tolerance
Date:7/26/2012

The Mariana Trench is the deepest feature of the Earth's surface. The water column there exerts a pressure of more than one thousand times normal atmospheric pressure at sea level, enough pressure to crush an SUV. Yet many organisms thrive in this seemingly inhospitable environment. A Japanese research team has been investigating how deep-sea bacteria adapt to such high-pressure conditions. They have identified a structural change that confers pressure-resistant properties on a particular protein found in bacteria. The findings, which the team will present at the meeting of the American Crystallographic Association (ACA), held July 28-Aug. 1, in Boston, Mass., may one day help guide the design of enzymes for use in high-pressure chemical industrial processes.

In general, pressure, like that caused by a water column thousands of feet deep, deforms proteins. As the proteins change shape, water can penetrate the protein's interior. Some proteins are better able to resist this incursion of water, but the molecular mechanisms of the pressure resistance aren't yet well understood.

"Our group is focusing on high-pressure protein crystallography, using 3-isopropylmalate dehydrogenase (IPMDH) as a model protein. The goal is to delve into the principles of the molecular mechanism of the pressure tolerance of proteins by comparing the structures of IPMDHs from organisms that thrive in high-pressure environments and those that are sensitive to high-pressure pressure environments," explains Nobuhisa Watanabe, a professor at the Synchrotron Radiation Research Center, Nagoya University.

To create the high pressures necessary for their studies, the team uses a diamond anvil cell (DAC), which consists of two opposing diamonds with a gasket compressed between the culets (the small, flat facet at the bottom of the diamonds).

The team's big discovery so far is that the initial water penetration at the molecular surface of the side opposite to
'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Speed and power of X-ray laser helps unlock molecular mysteries
2. Highlighting molecular clues to the link between childhood maltreatment and later suicide
3. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
4. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
5. The activity of a bacterial effector protein seen in molecular detail
6. Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats
7. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
8. PNAS: Precise molecular surgery in the plant genome
9. 5th Annual Advances in Biomolecular Engineering Symposium
10. 2012 Forecast for US Molecular Diagnostics Market Now Available From Global Information Inc.
11. Beyond the microscope: Identifying specific cancers using molecular analysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... research from Bjorn Brembs, professor of neurogenetics at the ... proof-of-concept figure allowing readers and reviewers to run the ... an important leap forward for scientific publishing, by demonstrating ... a scholarly output. , Figure 3 in fact doesn,t ... code to F1000Research , and the figure is ...
(Date:7/30/2014)... use of iodine-125 (125I) in cancer treatment has ... root ganglia are critical for neural transmission between ... Zhang and colleagues from Institute of Radiation Medicine, ... 125I could be implanted into rat dorsal root ... 125I seeds with different radioactivity (0, 14.8, 29.6 ...
(Date:7/30/2014)... Calif. , July 30, 2014 ... with the United States Air Force Research Laboratory ... by Binghamton University to ... performance monitoring (HPM). The $425,000 project, with contributions ... packaging firm i3 Electronics, Inc. ( Endicott, ...
Breaking Biology News(10 mins):F1000Research brings static research figures to life 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3
... into the nanoworld, the Jlich researchers used a scanning tunneling ... the needle of a record player and registers the atomic ... a millimetre) with minuscule electric currents. However, even though the ... atom, it has not been able so far to take ...
... new simulation of oil and methane leaked into the Gulf ... could form near the source of the pollution. The research ... depths and incorporates an estimated rate of flow from the ... the Gulf from April to mid July of this year. ...
... couldn,t fly, but it used its unusually large, rigid skull--coupled ... boxer Muhammad Ali. The agile creature repeatedly attacked and ... according to results of a new study published this week ... is the first detailed look at the predatory style of ...
Cached Biology News:Juelich researchers take a look inside molecules 2Deep plumes of oil could cause dead zones in the Gulf 2Ancient 'terror bird' used powerful beak to jab like boxer 2Ancient 'terror bird' used powerful beak to jab like boxer 3Ancient 'terror bird' used powerful beak to jab like boxer 4
(Date:7/30/2014)... , July 30, 2014 Regulus Therapeutics ... company leading the discovery and development of innovative medicines ... results and highlights for the quarter ended June 30, ... financial markets close. Regulus will host ... 2014, at 5:00 pm Eastern Daylight Time to discuss ...
(Date:7/30/2014)... July 30, 2014 W. R. ... release of the REVELERIS® Prep purification system ... preparative chromatographers, and other researchers to perform both ... single unit. , With the REVELERIS® Prep purification ... preparative chromatography modes with a simple touch of ...
(Date:7/30/2014)... A study presented at the 2014 ... of CSL Behring,s C1 Inhibitor (C1-INH) concentrate in ... sensitized patients. C1-INH is a human protein and ... The study shows that post-transplant treatment with ... of complement components 3 and 4, suggesting that ...
(Date:7/30/2014)...  Replikins Ltd. today released new data on changes ... the current outbreaks, the mean Ebola Reston gene Replikin ... 1995 and 2002 was 1.1; the mean Replikin Count ... in 2013, thus predicting the current outbreaks in humans. ... shown to be able to predict outbreaks (1).  For ...
Breaking Biology Technology:Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 3Grace Launches New REVELERIS® Prep Purification System 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3
... researchers at Rensselaer Polytechnic Institute have developed a new ... highly efficient refrigerators and cooling systems requiring no refrigerants ... innovation are a dash of nanoscale sulfur and a ... these solid-state cooling systems are thermoelectric materials, which can ...
... Solutions announced a processor modification in the popular ComLink ... make it the most powerful augmentative, alternative communication (AAC) ... the new i7 processor is up to seven times ... longer battery life and more memory storage. ...
... AMEX: IBIO) announced today the pricing of an underwritten ... gross proceeds of approximately $10 million.  Each unit consists of ... to purchase one share of common stock.  The warrants will ... exercisable beginning one year and one day from the date ...
Cached Biology Technology:Nature Materials: Quick-cooking nanomaterials in microwave to make tomorrow's air conditioners 2Nature Materials: Quick-cooking nanomaterials in microwave to make tomorrow's air conditioners 3Nature Materials: Quick-cooking nanomaterials in microwave to make tomorrow's air conditioners 4Powerful AAC Device With IntelĀ® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients 2iBio, Inc. Prices $10 Million Public Offering 2iBio, Inc. Prices $10 Million Public Offering 3iBio, Inc. Prices $10 Million Public Offering 4
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
Mouse monoclonal antibody raised against a partial recombinant RAB11B. NCBI Entrez Gene ID = RAB11B...
... polyclonal antibody raised against a ... Immunogen: SF3B2 (NP_006833, ... partial recombinant protein with GST ... Number: NM_006842 ...
...
Biology Products: