Navigation Links
Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
Date:5/16/2012

SAN DIEGO, CA May 16, 2012 Cardium Therapeutics (NYSE Amex: CXM) today announced a late-breaking poster presentation at the American Society of Gene & Cell Therapy (ASGCT) 15th Annual Meeting being held May 16-19, 2012 at the Pennsylvania Convention Center in Philadelphia, PA.

The new research findings demonstrate that cardiac ischemia plays an important role in adenovector gene transfection (delivery) in mammalian hearts. Based on this understanding, using a standard balloon angioplasty catheter, researchers have developed and tested a new method to induce transient ischemia during a non-surgical interventional cardiac procedure, which when coupled with the infusion of nitroglycerin, boosts the delivery (cell transfection) of an adenovector gene construct into heart cells. The increase in adenovector-based gene transfection with the new technique is over two orders of magnitude (>100 fold).

Cardium's new method of adenovector delivery takes advantage of the findings that transient ischemia appears to alter the permeability barrier of the vascular endothelium and may expose the blood to the coxsackie-adenovirus receptor mediating adenovector uptake by the heart. Balloon angioplasty catheters have been used for many years to dilate blocked coronary arteries, sometimes with use of a stent, and these catheters have also been used safely by cardiologists in patients with coronary artery disease to study the effects of brief ischemia. Cardium's new technique inflates the balloon in non-narrowed areas, and only enough to briefly interrupt flow using inflation pressure that is less than that used for performing angioplasty.

Cardium's recently initiated Russian-based ASPIRE Phase 3 / registration clinical study uses transient ischemia techniques during non-surgical percutaneous catheterization with a standard angioplasty catheter together with the intracoronary infusion of nitroglycerin with the Generx [Ad5FGF-4] product candidate
'/>"/>

Contact: Rex Graham
ragraham@sandiegobiotechnology.com
858-232-2706
San Diego Biotechnology Connection
Source:Eurekalert  

Page: 1 2

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. RNA molecules, delivery system improve vaccine responses, effectiveness
3. Depression during pregnancy can double risk of preterm delivery
4. Nanotechnology holds promise for STD drug delivery
5. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
6. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
7. New cancer drug delivery system is effective and reversible
8. UCSB scientists discover potential drug delivery system
9. U-Iowa improves delivery of cancer-fighting molecules
10. Encap agrees colonic drug delivery licensing deal
11. University of Iowa scientists use blood-brain barrier as therapy delivery system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
(Date:7/11/2014)... creating a new professorship in tissue engineering to ... Molecular Engineering and the Marine Biological Laboratory, supported ... and Eugene Bell Foundation., The Eugene Bell Professorship ... for Molecular Engineering. That endowed chair holder also ... Eugene Bell Center for Regenerative Biology and Tissue ...
(Date:7/11/2014)... researchers at the National Institute of Standards and ... their work more effectively, they often prove that ... was the case recently for M. Lorna De ... the growing specialization of glycomics. Glycomics is the ... glycans that are attached to proteins and lipids ...
(Date:7/11/2014)... animals often develop relationships with other group members to ... wild chacma baboons the strategy for grooming activities shows ... just published in the scientific journal Biology Letters ... baboons is not practiced without ulterior motives. To be ... the individual, while grooming another individual can provide access ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2Baboons groom early in the day to get benefits later 2
... cancer researchers have discovered a process that may explain ... one day lead to new therapies that prevent defective ... reported June 8 in the advance online issue of ... Biology Organization (EMBO). , Tumor cells that grow aggressively ...
... that genes control traits such as eye and hair color. ... found that the genes of one organism not only control ... of thousands of other organisms in a community. , ... an entire ecosystem. , "We're pushing a whole new field ...
... are leading a nationwide clinical trial to determine whether ... treatment for early-stage breast cancer. , "By using ... tumor will respond to chemotherapy, we're hoping to more ... hormonal therapy alone and which patients will truly benefit ...
Cached Biology News:MIT sheds light on how tumor cells form 2It's all in the genes 2It's all in the genes 3New genetic test for breast cancer 2
(Date:7/10/2014)... -- According to the International Atomic Energy Agency ... from terrorists acquiring sufficient quantities of plutonium or ... nuclear explosive device. The IAEA also notes that ... gram-level quantities, which can be challenging to detect ... new study appearing this week in the ...
(Date:7/10/2014)... study published today in the journal PNAS (Proceedings ... that time of day and sleep deprivation have a ... crucial when looking at the best time of day ... disease, and for administering medicines effectively. , Researchers from ... Research, London, investigated the links between sleep deprivation, body ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and ... on a single charge with the help of a ... material to replace the graphite traditionally used in one ... 10 times the energy storage capacity of graphite. A ... electrode was published today in Nature Communications . ...
(Date:7/10/2014)... University of Illinois at Urbana-Champaign provides new insights ... spin and heat at the nanoscale, and addresses ... data storage and information processing. , "Electrons ... In a typical charge current, electrons, spin-angular-momentum is ... David Cahill, a professor of materials science and ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2Time of day crucial to accurately test for diseases, new research finds 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3University of Illinois study advances limits for ultrafast nano-devices 2
... 32% Over Second Quarter 2007, - EPS of $0.63 per Basic Share, ... Charges of $1.36 per Basic Share, Increase of ... 56% Over Second Quarter 2007, SILVER ... announced its results of,operations for the quarter ended June 30, 2008., ...
... Granted in ... 2007, Expanding Commercial Protection, LONDON, July 31 ... biotechnology company, today announced that,the United States Patent and ... The Patent Office issued a ,Notice of,Allowance, for patent ...
... known that yeast, the humble ingredient that goes into our ... others. Glucose, their favorite food, provides more energy than any ... to ensure that they consume as much glucose as possible ... identified a previously unknown mechanism that allows yeast to shut ...
Cached Biology Technology:United Therapeutics Reports Second Quarter 2008 Financial Results 2United Therapeutics Reports Second Quarter 2008 Financial Results 3United Therapeutics Reports Second Quarter 2008 Financial Results 4United Therapeutics Reports Second Quarter 2008 Financial Results 5United Therapeutics Reports Second Quarter 2008 Financial Results 6Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent 2Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent 3Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent 4New yeast trick for eating favorite food: Details in Nature paper 2New yeast trick for eating favorite food: Details in Nature paper 3
... Thermo Savant SpeedVac Concentrators set the standard ... SC110A SpeedVac uses a combination of centrifugal force, ... a single run., SC110A comes equipped with:, , ... chemical compatibility , ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
...
... series of vacuum concentrators/centrifugal evaporators offers a ... to rapid and safe concentration of heat-labile ... with oil-free or high vacuum pumps, a ... selection of rotors (eliminating sample loss by ...
Biology Products: