Navigation Links
Deletion of any single gene provokes mutations elsewhere in the genome
Date:11/13/2013

Johns Hopkins researchers report that the deletion of any single gene in yeast cells puts pressure on the organism's genome to compensate, leading to a mutation in another gene. Their discovery, which is likely applicable to human genetics because of the way DNA is conserved across species, could have significant consequences for the way genetic analysis is done in cancer and other areas of research, they say.

Summarized in a report to be published on Nov. 21 in the journal Molecular Cell, the team's results add new evidence that genomes, the sum total of species' genes, are like supremely intricate machines, in that the removal of a single, tiny part stresses the whole mechanism and might cause another part to warp elsewhere to fill in for the missing part.

"The deletion of any given gene usually results in one, or sometimes two, specific genes being 'warped' in response," says J. Marie Hardwick, Ph.D., the David Bodian Professor of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health and a professor of pharmacology and molecular sciences at the school of medicine. "Pairing the originally deleted gene with the gene that was secondarily mutated gave us a list of gene interactions that were largely unknown before."

Hardwick says the findings call researchers to greater scrutiny in their genetic analyses because they could unwittingly attribute a phenomenon to a gene they mutated, when it is actually due to a secondary mutation.

"This work has the potential to transform the field of cancer genetics," Hardwick says. "We had been thinking of cancer as progressing from an initial mutation in a tumor-suppressor gene, followed by additional mutations that help the cancer thrive. Our work provides hard evidence that a single one of those 'additional mutations' might come first and actively provoke the mutations seen in tumor-suppressor genes. We hope that our findings in yeas
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Early-onset Parkinsons disease linked to genetic deletion
2. Extremely rare mitochondrial DNA deletions associated with aging can be accurately detected with Droplet Digital PCR
3. Single-cell genome sequencing gets better
4. Single mutation gives virus new target
5. Improved smartphone microscope brings single-virus detection to remote locations
6. Genomes of cholera bacteria from Haiti confirm epidemic originated from single source
7. Single-cell transfection tool enables added control for biological studies
8. Philips CX50 xMATRIX now offers world-class interventional and diagnostic features on single portable system
9. How much a single cell breathes
10. Cat and mouse: A single gene matters
11. Dartmouth researchers find there is no single sexy chin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Deletion of any single gene provokes mutations elsewhere in the genome
(Date:4/17/2014)... hit on a novel method to help kidney ... most effective treatment possible., Kidney stones represent a ... world. If left untreated, apart from being particularly ... other complications. In many patients treated successfully, stone ... effective pathological approach to diagnosis and treatment needs ...
(Date:4/17/2014)... a stark warning on the possible effects of gases ... 32 times that of carbon dioxide. Now a team ... as fully regenerable electron acceptors which helps explain why ... of being released to the atmosphere. However, there are ... enter into a vicious cycle to release large amounts ...
(Date:4/17/2014)... detected new early-warning signs of the potential loss of ... implications for the diagnosis and treatment of diabetic retinopathy, ... , "We had not expected to see such striking ... Ann Elsner, professor and associate dean in the IU ... "We set out to study the early signs, in ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... summer temperatures could mean some parts of southern England are ... according to a new book launched today (26 May 2008). ... College London, claims that if average summer temperatures in the ... of Hampshire and the Severn valley, which currently contain many ...
... mulberry leaves without feeling ill, and researchers have come ... special digestive enzyme that is not affected by mulberrys ... amount of alkaloids that inhibit enzymes that break down ... one type of sucrase called beta-fructofuranosidase is not affected ...
... -- Researchers from Weill Cornell Medical College may have ... of the world,s most common blood disorders, beta-thalassemia, commonly ... anemia is the most commonly inherited disease in the ... out of every 100,000 African-Americans. The World Health Organization ...
Cached Biology News:Research suggests parts of UK could be too hot for wine making by 2080 2Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf 2Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf 3Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf 4
(Date:1/15/2014)... MINNEAPOLIS , Jan. 15, 2014 ­ RedBrick ... and behavior change technology, today announces that EmblemHealth ... insurer and wellness company, is now providing the RedBrick ... digital coaching program, to all of its members. EmblemHealth ...
(Date:1/15/2014)... 2014 A study has been launched to ... 1 track could help to tackle the problem of obesity. ... (a GP surgery based in Stowmarket) and academics at University ... Telemetry technology, which is inspired by equipment used to ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2
... AlphaBio Centrix, a Nevada-based biotech corporation, announced this week its ... is a term used in programming wearable TheraEX (TM) ... energy field that surrounds all life forms. ... fact, in its basic form, it embodies seven major layers ...
... VILLAHERMOSA, Mexico, March 29, 2012  An advanced mobile bio-containment ... Tabasco to provide bio-surveillance of disease outbreaks. The US-built ... and is the first unit of its kind in ... This lab represents a new generation of technology ...
... Texas, March 28, 2012   Luminex Corporation ... Dr. Amy Altman, vice president of Biodefense will ... Conference , taking place March 27-29, 2012 in Denver, Colorado. ... of Defense,s Joint Program Executive Office for ...
Cached Biology Technology:AlphaBio Centrix, LLC Announces a New Discovery for Programming Energetic Patches 2US Lab Deployed to Boost Mexico's Response to Outbreaks of Infectious Disease 2Luminex Corporation to Speak at Joint Department of Defense and Environmental Protection Agency 5th National Bio-Threat Conference 2Luminex Corporation to Speak at Joint Department of Defense and Environmental Protection Agency 5th National Bio-Threat Conference 3Luminex Corporation to Speak at Joint Department of Defense and Environmental Protection Agency 5th National Bio-Threat Conference 4
Kit includes your choice of reagents for labeling 3 x 10 9 cells and EasySep magnet....
... Complete kit for stabilizing 1.5mg of ... been optimised for the stabilization of aqueous ... traditional methods such as guanidine, phenol/chloroform, silica, ... Our StabMRT Kits contain all the necessary ...
Blasticidin resistance gene (bsr), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Plasmid expressing Zeocin resistance gene....
Biology Products: