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Defective cell surface 'glue' is key to tumor invasion
Date:12/13/2010

t non-adhesive (proNcad) and adhesive (Ncad) forms of cadherins co-exist on tumour cell surfaces, but it is the ratio between these functionally opposite molecules that directly dictates the invasion potential of tumour cells." Because the differences between the two forms of cadherin are so small, previous studies have missed detecting the non-adhesive proNcad form on tumour cell surfaces. Hence it was assumed that all Ncad on the tumour cell surface was of the adhesive type. "We were astounded that this was not the case at all," says Dr. Colman.

"As a brain tumour surgeon, I know that stopping cancer cells from migrating is critical for patient survival," says Dr. Rolando Del Maestro, Director of The Brain Tumour Research Centre and a co-author on the study. "We are determined to improve treatment options for patients. We have already introduced new neurosurgical methods and technologies that are unique in North America and are spearheading multidisciplinary initiatives to advance brain tumour research."

Determining the ratios of Ncad and proNcad on the cell surface may serve as a tremendously valuable tool for the staging and progression of malignant tumors. The findings may also shed light on new treatment strategies to arrest the metastatic spread of invasive tumor cells.


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Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University
Source:Eurekalert

Page: 1 2

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