Navigation Links
Deep sequencing of breast cancer tumors to predict clinical outcomes after single dose of therapy
Date:12/12/2013

CLEVELAND: New research from University Hospitals (UH) Case Medical Center Seidman Cancer Center and Case Comprehensive Cancer Center at Case Western Reserve University examined how changes in the genetic composition of breast cancer tumors after brief exposure to either biologic therapy or chemotherapy can predict future clinical outcomes in patients.

Results showed that through deep genome sequencing, a reduction in the most commonly mutated genes in breast cancer could be observed after just one dose of preoperative therapy. Deep sequencing is a process that involves sequencing the same region multiple times to identify mutations within tumors that have an importance in cancer evolution. These new findings were presented during the 2013 San Antonio Breast Cancer Symposium.

"Genomics is the new frontier of cancer research, and this study shows that we may be able to accurately determine what treatment methods will and will not be effective for individual patients after just one dose of medicine," said Lyndsay Harris, MD, study investigator and Director, Breast Cancer Program, UH Seidman Cancer Center and Professor of Medicine at Case Western Reserve University School of Medicine. "The ability to understand potential clinical outcomes for patients earlier in the treatment process would provide physicians with better opportunity to personalize patients' medicines according to their own tumor responses."

More than 209,000 patients in the U.S. are diagnosed with breast cancer each year. The anticipated outcome of studying the genetic makeup of breast cancer patients is to determine who will benefit most from certain drug therapies and to use that information to create a personalized treatment plan for each patient involved. Dr. Harris and team are currently integrating whole genome profiles with deep sequencing data as they spearhead a new study at UH Seidman Cancer Center to validate these initial findings presented in San Antonio. <
'/>"/>

Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-844-5158
University Hospitals Case Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Powerful sequencing technology decodes DNA folding pattern
2. Sequencing works in clinical setting to help -- finally -- get a diagnosis
3. The sequencing of the tomato genome
4. DNA Sequencing: Emerging Technologies and Applications
5. Next-generation sequencing technology opens doors to discoveries
6. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
7. Exome sequencing gives cheaper, faster diagnosis in heterogeneous disease
8. An error-eliminating fix overcomes big problem in 3rd-gen genome sequencing
9. Exome sequencing of health condition extremes can reveal susceptibility genes
10. New genomic sequencing method enables smarter anaysis of individual cells
11. US-Russian collaboration develops new method for sequencing dark matter of life from a single cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform its shareholders ... Washington,s Department of Licensing, in the United States, awarded ... for driver,s licenses and identification cards to its subsidiary, Valid ... start in January 2015, with enrollment and card production starting ...
(Date:1/22/2015)... WINSTON-SALEM, N.C. , Jan. 16, 2015  A man-made ... working memory and other mental capabilities in adults with ... a pilot study led by researchers at Wake Forest ... 60 adults diagnosed with amnesic mild cognitive impairment (MCI) ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Global Wearable Technologies Market ... Share, Overview, Trends and Forecast 2014-2020" report ... Technologies are smart devices that can be worn ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... the movement and population size changes of Kiwis, Tuatara and ... been continually studied by conservationists and scientists. It now seems ... infect them. , Dr Alexei Drummond, from The University ... global research team analysing the genetic sequences of viruses in ...
... a Senior Research Associate at the Stowers Institute for ... and an investigator with the Howard Hughes Medical Institute, ... called Snail is expressed in a cyclic fashion during ... and chick embryo. , The findings, which were ...
... been well documented that, across human cultures and in most ... females. It's simple to blame male hormones, like testosterone, for ... genes, too. , Indeed such social behavior also has a ... at the University of Virginia Health System. "The differences ...
Cached Biology News:Finding a virus is not all bad news 2Stowers scientists demonstrate mechanism of vertebral formation 2Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers 2
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces ... of office space for Shire a leading biopharmaceutical company, at ... Transwestern | RBJ,s Robert Richards , president, and ... lease for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... DE (PRWEB) January 22, 2015 Controlled ... Pistoia Alliance, which helps companies check the legal requirements ... to expand to China. , As their international ... are globally adopting software solutions built as a result ...
(Date:1/22/2015)...  Varian Medical Systems (NYSE: VAR ), world leader ... commitment to sustainability with inclusion on a prestigious list of ... healthcare equipment company among the Corporate Knights Global 100 Most ... at Davos, Switzerland . ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... County ... 31 Global Med Technologies(R), Inc. ("Global Med" or ... information technology company, today announced that its Wyndgate Technologies(R) ... to Laurens County Health System of Clinton, South Carolina. ...
... 2 MDCT Sub-study to be Released Concurrent with AHA ... VIAP ), a biotechnology company focused on ... and metabolic disease, today announced that an abstract on ... been accepted for a poster presentation at the American ...
... Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI , ... Amended and Restated Distribution and License Agreement with ... for the Amended and Restated Distribution and License ... and Baxter initially entered into a Distribution and ...
Cached Biology Technology:Global Med Technologies(R) Licenses 90th Site in the Southeastern U.S. 2Global Med Technologies(R) Licenses 90th Site in the Southeastern U.S. 3VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 2VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 3VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 4Angiotech Pharmaceuticals, Inc. announces License Agreement with Baxter International Inc. 2Angiotech Pharmaceuticals, Inc. announces License Agreement with Baxter International Inc. 3Angiotech Pharmaceuticals, Inc. announces License Agreement with Baxter International Inc. 4