Navigation Links
Deep genomics
Date:1/13/2011

er again but with different antibodies. And we keep doing the experiment again and again and sending the data to the bioinformatics people."

As the data build up, the computer begins to look for groups of modifications that tend to occur together. For example, different sets of modifications might occur on genes that are repressed, paused, fluctuating or active.

In the end, the team found they were able to capture most of the complexity of the fruit fly's chromatin landscape with nine combinatorial states, that is, nine sets of DNA or protein modifications.

Beautiful chromosomes

Drosophila has a pretty simple genome, Elgin says, consisting of only four chromosomes.

The chromatin states can be visualized by drawing long, thin chromosomes and coloring them in bars that correspond to different chromatin states. But these vermicelli-like graphs are hard to read.

Another way to visualize the states is to fold the chromosomes into a geometric pattern that maintains the spatial proximity of nearby regions of the chromosome. This makes it easier to spot patches of uniform color that correspond to domains with the same chromatin state.

In these maps of the fruit fly's chromatin, differences are immediately evident.

The dark blue in the lower right corner of the left arm of the fruit fly's third chromosome (left middle) corresponds to heterochromatin, a tightly packed, usually silent form of DNA that forms around the structure called the centromere where the two arms of a chromosome are joined. (The centromere is the site where the chromosomes attach to the mitotic spindle during cell division.)

"The flecks of red mark transcription start sites," Elgin says, "spots where we find genes that are being actively expressed. They are usually flanked by states 2, 3 and 4 which we think are related to gene regulation. They include the enhancers, regions of DNA that facilitate the transcription of
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5 6 7

Related biology news :

1. Broad Institute awarded major grant to bolster epigenomics research
2. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
3. Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics
4. Computation and genomics data drive bacterial research into new golden age
5. New gene variants present opportunities in nutrigenomics
6. Nutrigenomics -- developing personalized diets for disease prevention
7. Human genomics in China
8. Mixing genomics and geography yields insights into life and environment
9. Comparative genomics reveals molecular evolution of Q fever pathogen
10. Complete Genomics releases proof-of-concept data for its sequencing technology for the first time
11. Venter, Somerville and Church highlight DOE/JGI genomics of energy and environment meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Deep genomics
(Date:4/18/2014)... A team of researchers led by a University of ... receive a $7.5 million Department of Defense grant to ... scientific foundations for the predictable design of light-weight, tough ... of structures from plants and animals, including the mantis ... biological systems have constructed over millions of years and ...
(Date:4/17/2014)... A drug under clinical trials to treat tuberculosis ... drugs that act against various bacteria, fungal infections and ... University of Illinois chemists and collaborators. , Led by ... determined the different ways the drug SQ109 attacks the ... target other pathogens from yeast to malaria and ...
(Date:4/17/2014)... Information about archaeological remains of ancient chili peppers in ... words for chili peppers in ancient dialects helped researchers ... value of multi-proxy data analysis. Their results are from ... in a special feature issue of the Proceedings ... and animal domestication edited by Dolores Piperno, staff scientist ...
Breaking Biology News(10 mins):Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3Multitarget TB drug could treat other diseases, evade resistance 2Chickens to chili peppers 2Chickens to chili peppers 3
... at work in protein production, a Princeton-led team has ... In doing so, they also have discovered how one ... natural cancer-fighting process. In a study appearing in ... , Thomas Silhavy, Princeton,s Warner-Lambert Parke-Davis Professor of Molecular ...
... the University of Oklahoma Health Sciences Center have shown the ... blood pressure. The results, which appear this month in the ... age and how we might live longer. Persistent hypertension, ... heart attack, heart failure, arterial aneurysm and is the leading ...
... weeks, Amanda Cobbs-Russell, a junior majoring in conservation biology ... a lifetime, requiring her to push herself to her physical ... people two Americans and three Canadians selected from ... and sleep among sweeping glaciers, polar ice and jagged granite ...
Cached Biology News:Princeton team learns why some drugs pack such a punch 2Princeton team learns why some drugs pack such a punch 3Anti-aging gene linked to high blood pressure 2UC Riverside student is 1 of only 5 persons selected for challenging Arctic expedition 2UC Riverside student is 1 of only 5 persons selected for challenging Arctic expedition 3
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... RESEARCH TRIANGLE PARK, N.C., April 18 The ... Hamner Institutes for Health,Sciences have signed a memorandum ... and translational research., Established with Carolina,s schools ... Business School, this unique partnership,capitalizes on the scientific ...
... Authorizing DNA Testing of Federal Arrestees Expected ... Ability to Combat Crime - - Complements Recent Moves ... N.J., April 18 Orchid Cellmark,Inc. (Nasdaq: ORCH ), ... new federal regulations previewed by the U.S.,Justice Department that are ...
... April 18 MED3OOO Group, Inc. (MED3OOO), ... Pathology,Consultants, Inc. of Michigan City, IN, recently ... of MED3OOO -- for billing, marketing, and ... a twenty-physician pathology practice,providing services to a ...
Cached Biology Technology:UNC-Chapel Hill, Hamner Institutes Announce Partnership to Accelerate Basic, Translational Research 2Orchid Cellmark Applauds Expansion of Federal Forensic DNA Identity Testing to Include All Arrestees 2Orchid Cellmark Applauds Expansion of Federal Forensic DNA Identity Testing to Include All Arrestees 3Orchid Cellmark Applauds Expansion of Federal Forensic DNA Identity Testing to Include All Arrestees 4Orchid Cellmark Applauds Expansion of Federal Forensic DNA Identity Testing to Include All Arrestees 5Pathology Consultants, Inc. Selects PSA, LLC, a MED3OOO Company, as Their Business Partner 2Pathology Consultants, Inc. Selects PSA, LLC, a MED3OOO Company, as Their Business Partner 3
Control primers and template for 5kb and 15 kb products....
0.2ml Gradient Block MBSR. Robot compatible block ejection mechanism. Stackable. (96 well block - holds 1 plate 0.2ml x 96 well plate)...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
A formulation of our Biolase DNA Polymerase which contains a Red Loading Dye...
Biology Products: