Navigation Links
Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype

MIAMI Puerto Rican women who had breast cancer that lacked estrogen and progesterone receptors and did not overexpress the HER2neu protein (triple-negative) had worse survival than those with other types of invasive breast cancer, according to a study presented at the Third AACR Conference on The Science of Cancer Health Disparities, held Sept. 30 Oct. 3, 2010.

"As the incidence of breast cancer rises in Puerto Rico, following U.S. trends, it is important to understand the association of disease subtypes with survival," said Ana P. Ortiz Martinez, M.P.H., Ph.D., associate professor and researcher at the University of Puerto Rico Cancer Center and the department of biostatistics and epidemiology, Graduate School of Public Health, University of Puerto Rico. "Breast cancer is a complex disease, with distinct subtypes with widely differing therapeutic indications and clinical outcomes."

This is the first published study on the impact of tumor subtypes and other clinical factors on breast cancer survival in Puerto Rico.

Researchers analyzed data for 974 female patients with invasive breast cancer who were diagnosed and treated in two main hospitals in Puerto Rico from 2000 to 2005.

The risk of breast cancer death for Puerto Rican women who had the triple-negative breast cancer subtype was more than twice as high as women with other tumor subtypes, even after accounting for a woman's age and cancer stage at diagnosis.

Women who were 50 years old or younger at the time of diagnosis and had regional/distant disease were also more likely to die as a result of their breast cancer.

Of the women studied, 22.5 percent had breast cancer that was HER2neu-positive (meaning that it overexpressed this protein); 60.9 percent of the breast cancers were positive for estrogen or progesterone receptors, but negative for HER2neu; and 16.6 percent were triple negative, neither overexpressing HER2neu nor receptive to estrogen or progesterone.

Findings, which were consistent with results described in previous studies of U.S. populations, will be useful in the development of cancer control strategies in Puerto Rico and may have an impact on future studies of targeted therapies to improve breast cancer survival in other Hispanic populations, said Ortiz Martinez.


Contact: Jeremy Moore
American Association for Cancer Research

Related biology news :

1. Babies born to native high-altitude mothers have decreased risk of low birth weight
2. Low levels of vitamin D linked to muscle fat, decreased strength in young people
3. Second lumpectomy for breast cancer reduces survival rates
4. U of MN study shows link between gene variations and cancer survival
5. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
6. Research challenges conventional notions about salmon survival
7. Salmon smolt survival similar in Columbia and Fraser rivers
8. Shared survival mechanism explains why good nerve cells last and bad cancer cells flourish
9. Survival in a Changing World: The Journal of Experimental Biology 2009 symposium
10. From seed to nuts: human ancestors face evolved to eat survival foods
11. Genetic adaptations key to microbes survival in challenging environment
Post Your Comments:
(Date:6/9/2016)... June 9, 2016 Paris ... Teleste,s video security solution to ensure the safety of people ... during the major tournament Teleste, an international ... and services, announced today that its video security solution will ... to back up public safety across the country. The system ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... Dollar project, for the , Supply and Delivery ... IT Infrastructure , to Decatur ... Identity Management Solutions. Numerous renowned international vendors participated in the ... was selected for the most compliant and innovative solution. The ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
Breaking Biology Technology: