Navigation Links
Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype

MIAMI Puerto Rican women who had breast cancer that lacked estrogen and progesterone receptors and did not overexpress the HER2neu protein (triple-negative) had worse survival than those with other types of invasive breast cancer, according to a study presented at the Third AACR Conference on The Science of Cancer Health Disparities, held Sept. 30 Oct. 3, 2010.

"As the incidence of breast cancer rises in Puerto Rico, following U.S. trends, it is important to understand the association of disease subtypes with survival," said Ana P. Ortiz Martinez, M.P.H., Ph.D., associate professor and researcher at the University of Puerto Rico Cancer Center and the department of biostatistics and epidemiology, Graduate School of Public Health, University of Puerto Rico. "Breast cancer is a complex disease, with distinct subtypes with widely differing therapeutic indications and clinical outcomes."

This is the first published study on the impact of tumor subtypes and other clinical factors on breast cancer survival in Puerto Rico.

Researchers analyzed data for 974 female patients with invasive breast cancer who were diagnosed and treated in two main hospitals in Puerto Rico from 2000 to 2005.

The risk of breast cancer death for Puerto Rican women who had the triple-negative breast cancer subtype was more than twice as high as women with other tumor subtypes, even after accounting for a woman's age and cancer stage at diagnosis.

Women who were 50 years old or younger at the time of diagnosis and had regional/distant disease were also more likely to die as a result of their breast cancer.

Of the women studied, 22.5 percent had breast cancer that was HER2neu-positive (meaning that it overexpressed this protein); 60.9 percent of the breast cancers were positive for estrogen or progesterone receptors, but negative for HER2neu; and 16.6 percent were triple negative, neither overexpressing HER2neu nor receptive to estrogen or progesterone.

Findings, which were consistent with results described in previous studies of U.S. populations, will be useful in the development of cancer control strategies in Puerto Rico and may have an impact on future studies of targeted therapies to improve breast cancer survival in other Hispanic populations, said Ortiz Martinez.


Contact: Jeremy Moore
American Association for Cancer Research

Related biology news :

1. Babies born to native high-altitude mothers have decreased risk of low birth weight
2. Low levels of vitamin D linked to muscle fat, decreased strength in young people
3. Second lumpectomy for breast cancer reduces survival rates
4. U of MN study shows link between gene variations and cancer survival
5. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
6. Research challenges conventional notions about salmon survival
7. Salmon smolt survival similar in Columbia and Fraser rivers
8. Shared survival mechanism explains why good nerve cells last and bad cancer cells flourish
9. Survival in a Changing World: The Journal of Experimental Biology 2009 symposium
10. From seed to nuts: human ancestors face evolved to eat survival foods
11. Genetic adaptations key to microbes survival in challenging environment
Post Your Comments:
(Date:11/10/2015)... 2015 About signature verification ... to identify and verify the identity of an ... the secure and accurate method of authentication and ... individual because each individual,s signature is highly unique. ... dynamic signature of an individual is compared and ...
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
(Date:10/29/2015)... 2015  Rubicon Genomics, Inc., today announced an ... its DNA library preparation products, including the ThruPLEX ... Plasma-seq kit. ThruPLEX Plasma-seq has been optimized for ... libraries for liquid biopsies--the analysis of cell-free circulating ... in cancer and other conditions. Eurofins Scientific is ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 24, 2015 Cepheid (NASDAQ: CPHD ) ... the following conference, and invited investors to participate via ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern ... New York, NY      Tuesday, December 1, ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an ... is bound to proteins, copper is also toxic to cells. With a $1.3 ... Institute (WPI) will conduct a systematic study of copper in the bacteria Pseudomonas ...
(Date:11/24/2015)... Nov. 24, 2015  Clintrax Global, Inc., a worldwide provider of ... , today announced that the company has set a new quarterly ... quarter on quarter growth posted for Q3 of 2014 to Q3 ... Mexico , with the establishment of an ... --> United Kingdom and ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model Aeronautics (AMA), ... MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View (FPV) racing ... AMA members have embraced this type of racing and several new model aviation pilots ...
Breaking Biology Technology: