Navigation Links
Decoy makes sitting duck of superbugs
Date:12/4/2007

Scientists from the John Innes Centre have proven that by taking a short stretch of DNA from a bacterium and delivering it with an existing antibiotic they can switch off antibiotic resistance.

Together with technology transfer company PBL, the scientists have launched a spin-out company, Procarta Biosystems Ltd, to develop the technology.

The DNA sequence acts as a decoy, disrupting gene expression and blocking resistance, said Dr Michael McArthur from JIC.

We are putting genetic information directly into drugs. This is the first application of a DNA based therapy.

The scientists have also patented a way of discovering decoys in bacteria without necessarily having to know the genes involved. This means they can develop effective new drugs against any bacterium within a couple of years and at a fraction of the normal cost.

The technology can give fresh patent life to existing antibiotics - when combined with a decoy they can be patented as a new drug.

This comes at a time when the number of new antibiotics receiving approval has dramatically declined. Faced with antibiotic resistance the pharmaceutical industry is unlikely to be able to deliver new products.

Natural resistance will always be hot on the heels of a new antibiotic because they co-evolve, said Dr McArthur. Ours is not a traditional pharmaceutical approach and provides a completely new challenge to bacteria.

The technology can also be used to improve the production of antibiotics by bacteria and to produce enzymes and other compounds using bacteria for use in industrial processes.

Many industrial processes are harsh and unsustainable, using petrochemicals, high temperatures and creating toxic by-products. In industrial biotechnology, also called white biotechnology, bacteria make medically and commercially important compounds biologically.

By using bacteria, many industrial processes could be cleaned up, said Dr McArthur.

The Procarta scientists found that the bacterium Streptomyces produces a particularly high yield of enzymes and proteins. Unusually, it can also secrete the proteins it produces so they do not have to be extracted.

Streptomyces is the enzyme producing bacterium with bells and whistles, set to make a major contribution to a market already predicted to be worth 400 million by 2010, said Dr McArthur.

We use the products of white biotechnology in our everyday lives. They contribute to ingredients in the food we eat, energy we use that has been generated with renewable biomass rather than fossil fuels, medicines we take, and everyday products such as detergents, paint and paper.


'/>"/>

Contact: Zoe Dunford
zoe.dunford@bbsrc.ac.uk
44-160-325-5111
Norwich BioScience Institutes
Source:Eurekalert

Related biology news :

1. New drug makes weight loss safer
2. How mother of thousands makes plantlets
3. For honey bee queens, multiple mating makes a difference
4. Scientists spy enzyme that makes us unique
5. Thinking makes it so: Science extends reach of prosthetic arms
6. Choosing dry or wet food for cats makes little difference
7. Technique controls nanoparticle size, makes large numbers
8. MU study finds that sitting may increase risk of disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... Minn., July 20, 2017   KCNQ2 Cure ... genetic evaluations company, today announced that they have ... a genetic mutation implicated in KCNQ2 epileptic encephalopathy. ... for a second case involving an additional KCNQ2 ... Cure Alliance and Pairnomix entered into a collaboration ...
(Date:7/18/2017)... ... July 18, 2017 , ... Genedata, ... a leading science and technology company, has implemented Genedata Biologics ™ to ... areas of Oncology, Immunology, and Neurodegenerative Diseases. , The need to systematically evaluate ...
(Date:7/17/2017)... (PRWEB) , ... July 17, 2017 , ... ... its drug delivery device testing capabilities to encompass the full series of ISO ... comprehensive evaluations of fittings for medical device and drug delivery systems. With this ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... Ph.D. , recently participated in the BiG (Biomedical Innovation Group) annual meeting in ... discussions of CAR-T (chimeric antigen receptor T-cell) therapy, a rapidly developing highly personalized ...
Breaking Biology Technology: