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Decoy makes sitting duck of superbugs
Date:12/4/2007

Scientists from the John Innes Centre have proven that by taking a short stretch of DNA from a bacterium and delivering it with an existing antibiotic they can switch off antibiotic resistance.

Together with technology transfer company PBL, the scientists have launched a spin-out company, Procarta Biosystems Ltd, to develop the technology.

The DNA sequence acts as a decoy, disrupting gene expression and blocking resistance, said Dr Michael McArthur from JIC.

We are putting genetic information directly into drugs. This is the first application of a DNA based therapy.

The scientists have also patented a way of discovering decoys in bacteria without necessarily having to know the genes involved. This means they can develop effective new drugs against any bacterium within a couple of years and at a fraction of the normal cost.

The technology can give fresh patent life to existing antibiotics - when combined with a decoy they can be patented as a new drug.

This comes at a time when the number of new antibiotics receiving approval has dramatically declined. Faced with antibiotic resistance the pharmaceutical industry is unlikely to be able to deliver new products.

Natural resistance will always be hot on the heels of a new antibiotic because they co-evolve, said Dr McArthur. Ours is not a traditional pharmaceutical approach and provides a completely new challenge to bacteria.

The technology can also be used to improve the production of antibiotics by bacteria and to produce enzymes and other compounds using bacteria for use in industrial processes.

Many industrial processes are harsh and unsustainable, using petrochemicals, high temperatures and creating toxic by-products. In industrial biotechnology, also called white biotechnology, bacteria make medically and commercially important compounds biologically.

By using bacteria, many industrial processes could be cleaned
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Contact: Zoe Dunford
zoe.dunford@bbsrc.ac.uk
44-160-325-5111
Norwich BioScience Institutes
Source:Eurekalert

Page: 1 2

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