Navigation Links
Decoding dengue
Date:7/16/2014

Scientists have discovered a new pathway the dengue virus takes to suppress the human immune system. This new knowledge deepens our understanding of the virus and could contribute to the development of more effective therapeutics.

For years, the conventional approach to target the dengue virus was through vector control, which was regarded to be the most effective method. This is because the mechanics of the virus have been elusive, which in turn hampered the development of effective treatments and vaccines.

Fortunately a new study, published in the prestigious journal PLOS Pathogens, has given us fresh insight into the virus. Researchers from the Program in Emerging Infectious Diseases (EID) at Duke-NUS Graduate Medical School Singapore (Duke-NUS) have discovered a new way that dengue virus-2 (DENV-2) uses to evade the human defense system. Typically, when a virus enters the body and infects cells, it induces the production and release of interferons (IFNs), which are proteins that raise the bodies' anti-viral defense mechanisms.

The dengue virus enters the cell and produces large quantities of a non-coding, highly-structured viral RNA termed sfRNA, which is part of the genetic material of the dengue virus. The team found that sfRNA attaches itself to G3BP1, G3BP2 and CAPRIN1, proteins in the cell that typically help in producing antiviral proteins in response to IFNs. Because of this interaction, the cell is unable to mount its antiviral defenses and protect itself against virus replication.

"These findings were surprising because in 30 years of RNA and dengue related research this new mechanism was never discovered," explained senior author Professor Mariano Garcia-Blanco from EID.

"We not only found a new way in which the pathogen (dengue virus) interferes with the host response (human immune system) we also uncovered the first mechanistic insight into how this non-coding RNA works. This discovery opens the door to explore therapeutics through this channel."

These findings highlight new steps that regulate our immune response, and in the case of dengue, how the virus has learnt how to avoid these defenses. It also highlights the differences between the four dengue strains and how more research is needed to understand this highly complex virus.

"The dengue virus employs multiple strategies to evade our immune responses. These strategies provide the virus with redundancies so that if one approach fails, it has others to provide it with the necessary means to thrive," commented Associate Professor Eng Eong Ooi, Deputy Director of EID.

"Prof Garcia-Blanco's lab describes a novel way in which dengue virus is able to avoid being killed by our antiviral response. It produces fragments of its own genome to act like a sponge to soak up those factors needed to produce the virus killing machinery. This work is an important contribution to our overall understanding of the evasive strategies employed by dengue virus, which is important for devising new and effective methods for treating dengue patients."


'/>"/>

Contact: Dharshini Subbiah
dharshini.subbiah@duke-nus.edu.sg
659-616-7532
Duke-NUS Graduate Medical School Singapore
Source:Eurekalert

Related biology news :

1. Decoding worm lingo
2. Decoding the secrets of balance
3. Decoding the genome of the camel
4. Gene decoding obeys road traffic rules
5. Mathematical and biochemical design features for cell decoding of pulses revealed
6. Decoding characteristic food odors
7. Researchers identify Achilles heel of dengue virus, target for future vaccines
8. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
9. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
10. Research advances therapy to protect against dengue virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
(Date:3/22/2017)...   Neurotechnology , a provider of high-precision ... the release of the SentiVeillance 6.0 ... recognition using up to 10 surveillance, security and ... new version uses deep neural-network-based facial detection and ... a Graphing Processing Unit (GPU) for enhanced speed. ...
(Date:3/20/2017)... PMD Healthcare announces the release of its ... System (WMS), a remote, real-time lung health monitoring and ... is a Medical Device, Digital Health, and Chronic Care ... innovative solutions that empower people to improve their healthcare ... developed the first ever personal spirometer, Spiro PD, which ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... ... Biologist Dawn Maslar MS has found a biomarker that she claims verifies ... The Neuroscience of Meeting, Dating, Losing Your Mind, and Finding True Love, Maslar found ... step, in my estimation, was to scientifically track the evidence of commitment in men,” ...
(Date:6/20/2017)... ... June 20, 2017 , ... GigaGen Inc ., a ... repertoires, announces launch of its new Surge(TM) Discovery service at the ... GigaGen, will present on Surge at the conference. , Surge is the new, ...
(Date:6/16/2017)... ... 2017 , ... Cognition Corporation , a software company ... of its “From the Helm” Webinar Series. , The next two free ... design control exercises. Led by David Cronin, Cognition’s CEO, the half-hour public webinars ...
(Date:6/15/2017)... ... June 15, 2017 , ... The ... an artist’s journey through creative experimentation and interdisciplinary collaboration. Feature Creep, a solo ... 22nd. An opening reception will be held at EKG, located at 3600 Market ...
Breaking Biology Technology: