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December 2008 highlights from Biology of Reproduction
Date:11/19/2008

y. In a paper on p. 1038, Park et al. report genetic background effects on the phenotype produced by Dax1 (Nrob1) deficiency in mice. Intriguing work from several laboratories has demonstrated that the severity of the Dax1-deficiency phenotype is greatest on a C57BL/6J background and milder on a 129 genetic background. Park et al. studied individuals comprised of mixed, 129 and C57BL/6J backgrounds and defined a quantitative range of intermediate phenotypes and gene expression patterns (such as the augmentation of Stra8 expression by C57BL/6J background noted by others). Appreciating the significance of these results will require defined mapping crosses to determine the C57BL/6J alleles modifying gonadal sex determination and germ cell fate. Nonetheless, the collective studies to date highlight the importance of genetic context in the analysis of sex differentiation pathways.

Susan Y. Park, Eun-Jig Lee, Donna Emge, Carolyn L. Jahn, and J. Larry Jameson. A Phenotypic Spectrum of Sexual Development in Dax1(Nr0b1)-Deficient Mice: Consequence of the C57BL/6J Strain on Sex Determination. Biol Reprod 2008; 79:1038�. Published in BOR-Papers in Press 16 July 2008;

DOI 10.1095/biolreprod.108.069492
http://www.biolreprod.org/cgi/content/full/79/6/1038?etoc


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Contact: Judith Jansen
ssradmin@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

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