Navigation Links
December 2008 highlights from Biology of Reproduction
Date:11/19/2008

SO-What?

At the time of birth, mouse ovaries are essentially a bag full of primordial oocytes, around which primordial follicles are forming. This key time in ovarian development establishes the population of oocytes and follicles and instigates evelopment of a cohort of follicles. If follicles fail to form, the result is oocyte demise, yet oocytes are also essential for follicular development. Several factors key to follicular formation and oocyte survival have been discovered recently, such as FIGLA and LHX8. Now, Choi et al. (p. 1176) report that SOHLH2 spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor 2) is crucial for follicular development and oocyte survival. Although some primordial follicles appear to form in Sohlh2-null ovaries, the oocytes are rapidly lost and follicles do not develop to the primary stage. Importantly, only low levels of key oogenic transcripts such as Figla, Gdf9, Lhx8, and Pou5f1 are expressed by the null oocytes at birth, suggesting that SOHLH2 production requires full expression of these important factors. Therefore, SOHLH2 is of fundamental importance for both oogenic and folliculogenic processes.

Youngsok Choi, Daniel Yuan, and Aleksandar Rajkovic. Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression. Biol Reprod 2008; 79:1176�. Published in BOR-Papers in Press 27 August 2008;

DOI 10.1095/biolreprod.108.071217
http://www.biolreprod.org/cgi/content/full/79/6/1176?etoc


Background noise, or a symphony?

Genetic background effects can plague researchers studying developmental processes in mammalian organisms. However, because such effects are due to differences in many allelic combinations, they are also key indicators of regulatory complexity. In a paper on p. 1038, Park et al. report genetic background effects on the phenotype produced by Dax1 (Nrob1) deficiency in mice. Intriguing work from several laboratories has demonstrated that the severity of the Dax1-deficiency phenotype is greatest on a C57BL/6J background and milder on a 129 genetic background. Park et al. studied individuals comprised of mixed, 129 and C57BL/6J backgrounds and defined a quantitative range of intermediate phenotypes and gene expression patterns (such as the augmentation of Stra8 expression by C57BL/6J background noted by others). Appreciating the significance of these results will require defined mapping crosses to determine the C57BL/6J alleles modifying gonadal sex determination and germ cell fate. Nonetheless, the collective studies to date highlight the importance of genetic context in the analysis of sex differentiation pathways.

Susan Y. Park, Eun-Jig Lee, Donna Emge, Carolyn L. Jahn, and J. Larry Jameson. A Phenotypic Spectrum of Sexual Development in Dax1(Nr0b1)-Deficient Mice: Consequence of the C57BL/6J Strain on Sex Determination. Biol Reprod 2008; 79:1038�. Published in BOR-Papers in Press 16 July 2008;

DOI 10.1095/biolreprod.108.069492
http://www.biolreprod.org/cgi/content/full/79/6/1038?etoc


'/>"/>

Contact: Judith Jansen
ssradmin@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. December GEOLOGY and GSA TODAY media highlights
2. Highlights from the December 2007 Journal of the American Dietetic Association
3. Story tips from the Department of Energys Oak Ridge National Laboratory, December 2007
4. Emerging field of neuroecology is showcased in December issue of the Biological Bulletin
5. September Geology and GSA Today media highlights
6. Highlights from the September 2007 Journal of the American Dietetic Association
7. AGU journal highlights -- Sept. 6, 2007
8. IDEMA Reveals Program Highlights for DISKCON USA 2007
9. IDEMA Reveals Program Highlights for DISKCON USA 2007
10. October Geology and GSA Today media highlights
11. Media highlights in the November issues of Biophysical Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... -- Yissum Research Development Company of the Hebrew ... Hebrew University, announced today the formation of Neteera ... human biological indicators. Neteera Technologies has completed its first ... ... emissions from sweat ducts, enables reliable and speedy biometric ...
(Date:3/11/2016)... , March 11, 2016 ... market research report "Image Recognition Market by Technology (Pattern ... and Advertising), by Deployment Type (On-Premises and Cloud), by ... 2022", published by MarketsandMarkets, the global market is expected ... USD 29.98 Billion by 2020, at a CAGR of ...
(Date:3/9/2016)... 2016 Nigeria . ... than 23,000 public service employees either did not exist ... salary unlawfully.    --> Nigeria ... more than 23,000 public service employees either did not ... their salary unlawfully.    --> DERMALOG, the ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... ... May 02, 2016 , ... StarNet Communications Corp, ( http://www.starnet.com/ ) a leading ... Secure Remote Desktop modules to its flagship X-Win32 PC X server. The new ... to the user’s PC over encrypted SSH. , Traditionally, users of PC X servers ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... in personalized pain medicine, is excited to announce the launch of the ... public health studies, volunteerism, and education to promote the use of personalized medicine ...
(Date:4/29/2016)... Denver, CO (PRWEB) , ... April 29, 2016 ... ... on addressing the necessary fundamentals to transform technology into a viable company, CereScan’s ... enable growth. Mr. Kelley, a recognized leader and mentor in the Denver ...
(Date:4/29/2016)... April 29, 2016 Elekta is ... update to its industry-leading treatment planning software, is available ... Monaco version 5.11 provides significant performance ... calculation speeds up to four times faster than in ... the industry,s gold standard Monte Carlo ...
Breaking Biology Technology: