Navigation Links
December 2008 highlights from Biology of Reproduction
Date:11/19/2008

SO-What?

At the time of birth, mouse ovaries are essentially a bag full of primordial oocytes, around which primordial follicles are forming. This key time in ovarian development establishes the population of oocytes and follicles and instigates evelopment of a cohort of follicles. If follicles fail to form, the result is oocyte demise, yet oocytes are also essential for follicular development. Several factors key to follicular formation and oocyte survival have been discovered recently, such as FIGLA and LHX8. Now, Choi et al. (p. 1176) report that SOHLH2 spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor 2) is crucial for follicular development and oocyte survival. Although some primordial follicles appear to form in Sohlh2-null ovaries, the oocytes are rapidly lost and follicles do not develop to the primary stage. Importantly, only low levels of key oogenic transcripts such as Figla, Gdf9, Lhx8, and Pou5f1 are expressed by the null oocytes at birth, suggesting that SOHLH2 production requires full expression of these important factors. Therefore, SOHLH2 is of fundamental importance for both oogenic and folliculogenic processes.

Youngsok Choi, Daniel Yuan, and Aleksandar Rajkovic. Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression. Biol Reprod 2008; 79:1176�. Published in BOR-Papers in Press 27 August 2008;

DOI 10.1095/biolreprod.108.071217
http://www.biolreprod.org/cgi/content/full/79/6/1176?etoc


Background noise, or a symphony?

Genetic background effects can plague researchers studying developmental processes in mammalian organisms. However, because such effects are due to differences in many allelic combinations, they are also key indicators of regulatory complexity. In a paper on p. 1038, Park et al. report genetic background effects on the phenotype produced by Dax1 (Nrob1) deficiency in mice. Intriguing work from several laboratories has demonstrated that the severity of the Dax1-deficiency phenotype is greatest on a C57BL/6J background and milder on a 129 genetic background. Park et al. studied individuals comprised of mixed, 129 and C57BL/6J backgrounds and defined a quantitative range of intermediate phenotypes and gene expression patterns (such as the augmentation of Stra8 expression by C57BL/6J background noted by others). Appreciating the significance of these results will require defined mapping crosses to determine the C57BL/6J alleles modifying gonadal sex determination and germ cell fate. Nonetheless, the collective studies to date highlight the importance of genetic context in the analysis of sex differentiation pathways.

Susan Y. Park, Eun-Jig Lee, Donna Emge, Carolyn L. Jahn, and J. Larry Jameson. A Phenotypic Spectrum of Sexual Development in Dax1(Nr0b1)-Deficient Mice: Consequence of the C57BL/6J Strain on Sex Determination. Biol Reprod 2008; 79:1038�. Published in BOR-Papers in Press 16 July 2008;

DOI 10.1095/biolreprod.108.069492
http://www.biolreprod.org/cgi/content/full/79/6/1038?etoc


'/>"/>

Contact: Judith Jansen
ssradmin@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. December GEOLOGY and GSA TODAY media highlights
2. Highlights from the December 2007 Journal of the American Dietetic Association
3. Story tips from the Department of Energys Oak Ridge National Laboratory, December 2007
4. Emerging field of neuroecology is showcased in December issue of the Biological Bulletin
5. September Geology and GSA Today media highlights
6. Highlights from the September 2007 Journal of the American Dietetic Association
7. AGU journal highlights -- Sept. 6, 2007
8. IDEMA Reveals Program Highlights for DISKCON USA 2007
9. IDEMA Reveals Program Highlights for DISKCON USA 2007
10. October Geology and GSA Today media highlights
11. Media highlights in the November issues of Biophysical Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... 2017 , ... LabRoots , the leading provider of scientific trending news ... is announcing a new textbook scholarship, the second scholarship in the LabRoots program. ... or older, pursuing a degree in one of the life sciences. The scholarship will ...
(Date:5/24/2017)... ... May 23, 2017 , ... ... provider of high quality relocatable and permanent modular buildings, announced the launch ... tools and modern office design characteristics to help support on-site teamwork and ...
(Date:5/24/2017)... Ebola resurfaces in the Democratic Republic of Congo ... reported, a new analysis of the Ebola gene polymerase Replikin ... 2014 and 2017 outbreaks of the disease.  ... the 2014 outbreak. An analysis of the latest data showed ... which again precedes the current outbreak in the DRC. Sequence ...
(Date:5/23/2017)... Yorba Linda, Ca (PRWEB) , ... ... ... stem cells (PSCs) offer an unlimited source of human cardiovascular cells for ... efficient cardiac-directed differentiation methods makes it possible to generate large numbers of ...
Breaking Biology Technology: