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Deceiving cell walls
Date:1/28/2009

toxin-releasing self-destruction (autolysis) typical of pneumococci at the end of their life cycle is stopped.

However, choline is not suitable for use as a drug because an effective dose would be far too high. The researchers thus developed the foundation for a new drug that binds CBP much more strongly than individual choline molecules. Their trick: the drug imitates the choline architecture of the cell wall by presenting multiple choline groups. As a scaffold for their assembly of choline groups, the researchers chose to use dendrimers (tree-like branched molecules), attaching the choline groups to the tips of the "branches". The choline ends can simultaneously occupy multiple choline binding sites of the CBP. The dendrimer frameworks are flexible enough to meet the spatial demands of the application. The required dosage of this CBP inhibitor lies within the range that is acceptable for pharmaceuticals.


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Contact: Jess M. Sanz
jmsanz@umh.es
34-966-658-460
Wiley-Blackwell
Source:Eurekalert  

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Deceiving cell walls
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