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'Death protein' research secures funding for UCF scientists
Date:4/8/2008

hat among its activities mediates the death of cells, since her days as a post-doctoral scientist at the National Cancer Institute (NCI) more than five years ago. In 2003, she received $466,000 of National Institutes of Health (NIH) funding in the form of a career development award to study how BAX is activated to cause the death of immune cells. Instead of answers her diligent analysis, employing traditional biological techniques, revealed more questions. In order to crack the BAX puzzle and find those elusive answers, she needed a new approach. Khaled found that approach in a partnership that was originally created to help train UCF graduate students in biophysics and computational modeling of protein structure.

In addition to receiving a $1 million grant from NIH, Khaled, Tatulian and Selby have submitted two manuscripts on the joint work one describing the computer modeling side and the other focusing on the biological findings.

Khaled has also received $919,000 from the NIH for a related study on the function of an immunological signaling protein known as Interleukin 7 that supports the bodys immune system to fight off infections and when aberrantly expressed could also underlie the development of cancer.

Dr. Khaled is truly an outstanding Florida researcher to compete with the best in the country and win, said Pappachan Kolattukudy, director of the Burnett School of Biomedical Sciences in the College of Medicine. We are fortunate to have her as part of our team, making significant strides in our search for cures to some of the worlds most common and deadly diseases.


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Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert

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