Navigation Links
'Death protein' research secures funding for UCF scientists
Date:4/8/2008

The marriage of computer modeling, biophysics and immunology has landed a University of Central Florida scientist more than $1 million in funding for her work, which could have profound benefits in the search for cures to cancer and heart disease.

UCF assistant professor Annette Khaled is conducting research into what triggers the death protein. The death protein BAX appears to annihilate surrounding cells. If its secrets could be unlocked and controlled, it could be a key tool in saving lives.

By identifying one of the mechanisms that leads to the fragmentation and ultimately death of the cells of the immune system, Khaled hopes to develop a peptide-based therapeutic approach that can be used to either stimulate the death of diseased or cancerous cells or protect cells whose inappropriate death causes heart disease or brain damage.

Khaled has put together a team of researchers at UCF with a variety of backgrounds to conduct the research.

The NIH is making an effort to foster interdisciplinary research, Khaled said because biomolecular research is so complicated. Teams, which use the strengths of a variety of disciplines to study cell function have an edge compared to those who stick with one expertise and traditional methods.

Biophysical approaches and computational modeling methods helped us see what is happening biologically, Khaled said.

When she arrived at UCF in 2002 she identified UCF biophysicist, Suren Tatulian, as having the biophysical know how to help her understand how proteins interact with membranes. UCF protein chemist, Thomas Selby, has the computational modeling skills that could help her design new biological experiments.

Together, the three scientists discovered that the occupancy of a prominent hydrophobic groove within the molecular structure of BAX could be the key to controlling the proteins lethal activity.

Khaled has studied the inner workings of BAX, a protein t
'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bleeding, not inflammation, is major cause of early lung infection death
2. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
3. Scientists find how amber becomes death trap for watery creatures
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. Earlier bites by uninfected mosquitoes boost West Nile deaths in lab mice
6. Leading cause of death in preemies might be controlled by resetting a molecular switch
7. The birth and death of dopamine neurons: A new model for neurodegeneration
8. Marsupial lion tops African lion in fight to death
9. Human deaths from shark attacks hit 20-year low last year
10. From delicious to death: Understanding taste
11. Coral reefs and climate change: Microbes could be the key to coral death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... know what goes wrong with your muscles because of age, ... "normal" actually is. That,s where a new research report published ... Journal comes in. In the report, a team ... that can help scientists "see" which genes are active in ... never-before-detected gene activity and that men have approximately 400 more ...
(Date:9/30/2014)... release is available in German . ... their behavioural response to risky situations such as exposure ... Ornithology now found in a long-term study on different ... both metabolic rate and ambient temperature. High metabolic rates ... as in these scenarios birds were more likely to ...
(Date:9/30/2014)... a suite of perilous threats in today,s ocean. ... climate change, fragile coral ecosystems are disappearing at ... some species of corals surrounding the island of ... in their tropical environment: coral guard-crabs. New research ... Marine Station scientist Seabird McKeon and the museum,s ...
Breaking Biology News(10 mins):Scientists identify which genes are active in muscles of men and women 2Risky metabolism 2Smithsonian scientists discover coral's best defender against an army of sea stars 2
... , Jan. 24, 2013 /PRNewswire-iReach/ -- The companion diagnostics ... has become one of the most promising areas within ... companies are now entering the highly attractive market of ... developing a combination product. The explosive M&A trend in ...
... their mother,s diet during gestation and lactation were found to ... than those not exposed to the chemical, researchers at the ... BPA is a chemical most commonly found in the lining ... in many hard plastic bottles, including baby bottles, but many ...
... Researchers at the University of Pittsburgh School of ... key HIV protein. In findings published online today in ... this vulnerable spot could stop the virus from replicating, ... Previous research demonstrated that a small HIV protein ...
Cached Biology News:Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player 2Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player 3Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player 4Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player 5Female mice exposed to BPA by mothers show unexpected characteristics 2Female mice exposed to BPA by mothers show unexpected characteristics 3Pitt team finds 'Achilles Heel' of key HIV replication protein 2
(Date:10/1/2014)... 30, 2014 In response to ... to address sales, training and consumer engagement challenges, ... innovative mobile applications to turn their clients’ visions ... latest customized mobile app creations, are now featured ... In partnership with Toyota, StudioPMG created a robust ...
(Date:10/1/2014)... The U.S. Department of Labor has ... Edwardsville as part of the Trade Adjustment Assistance Community ... co-administered by the Department of Labor and Department of ... Thomas E. Perez and Secretary of Education Arne Duncan ... grants to nearly 270 colleges across the country. ...
(Date:9/30/2014)... available in German . ... Mnchen (TUM) have demonstrated a new kind of building ... future computer chips could be based on three-dimensional arrangements ... enabling technology of the semiconductor industry CMOS fabrication ... researchers and collaborators at the University of Notre Dame ...
(Date:9/30/2014)... Sept. 30, 2014 Nematicide is a ... Nematodes are microscopic parasitic roundworms, found in massive ... other plants and animals. Nematicides have tended to ... properties promoting migration through the soil. A single ... plant-parasitic nematodes. With more than 10,000 species classified, ...
Breaking Biology Technology:Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... Calif. and MONROVIA, Calif., Jan. 6, 2011 Amgen ... today that they will collaborate to develop XmAb ® ... and CD32b.  XmAb5871 is currently in late-stage preclinical development ... Under the terms of the agreement, Amgen has the ...
... SAN FRANCISCO, Jan. 6, 2011 Vista Partners ... Therapeutics, Inc. (Nasdaq: OPXA ) and raised ... Silver, Principal Analyst at Vista Partners stated, "Opexa announced yesterday ... for the treatment of Multiple sclerosis , is now ...
... 6, 2011 BioInformatics, LLC announces the release of ... Technologies:  Market Insights for Life Science Suppliers (#10-005) This ... respond in a timely fashion to the rapidly changing ... LLC quantifies and characterizes the market for genetic analysis ...
Cached Biology Technology:Amgen and Xencor Enter Option Deal to Co-Develop Xencor's Novel Antibody for Autoimmune Diseases 2Amgen and Xencor Enter Option Deal to Co-Develop Xencor's Novel Antibody for Autoimmune Diseases 3Vista Partners Updates Coverage on Opexa Therapeutics, Inc.; Raises Target Price From $4.40 to $6.50 2BioInformatics, LLC New Market Report - Genomics Technologies 2
... are stored within neurons in vesicles ... in the synaptic bouton. Synaptosomes ... from other cellular debris. Abnormalites ... in many pathological condtions. Conditions ...
... Translation Detection Systems allow non-radioactive detection ... these systems, biotinylated lysine residues are ... eliminating the need for labeling with ... This biotinylated lysine is added to ...
... BFD Series Hybridization chambers with forced ... F above ambient up to 99.9 C / ... temperature accuracy and reproducible results DS controller ... temperature setting with an accuracy of a tenth ...
... the value of your microarray data using ... you need from consultation to extensive data ... methods. Utilize our expertise in combination with ... your own microarray experiments., ,Normalization and basic ...
Biology Products: