Navigation Links
Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
Date:7/1/2008

for Chemistry along with former Fox Chase researcher Irwin Rose, Ph.D., for the discovery of ubiquitin-mediated protein degradation at Fox Chase.

Their findings show that MCF2 joins a previously known group of proteins the mitotic checkpoint complex to inhibit the pro-division APC/C protein complex. According to Yen, MCC and MCF2 team up to prevent the activation of APC/C by a signaling molecule called Cdc20. "The mitotic checkpoint is a molecular failsafe system, an intricate clockwork mechanism to ensure that everything is working properly before it allows a cell to divide," Yen says.

When sells divide, one of the first steps is to replicate DNA, which are in the familiar X- and Y-shaped structures called chromosomes. Before the cell can split, the mitotic checkpoint proteins monitor the mechanical connection between microtubule fibers (which act like rope to pull apart replicated pairs of chromosomes) and the chromosomes. If everything is in place, the checkpoint proteins release APC/C and allow division to continue. If not, the cell self-destructs before it can divide.

If the checkpoint proteins themselves are faulty, however, mitosis results in aneuploidy, the loss or gain of chromosomes in the daughter cells. This increases the risk of cancer, and promotes the resistance of cancer cells to chemotherapies.

Certain cancer drugs, such as paclitaxel and gemcitabine, exploit the mechanisms of mitosis to kill cancer cells. Although they act through very different mechanisms, both paclitaxel and gemcitabine sabotage the events monitored by the checkpoint proteins, which then leads to cell death. According to Yen, a deeper understanding of the mechanisms of mitosis will make these drugs, and others like them, more effective and more enduring.

While the researchers characterize the discovery as an important step in understanding mitosis, the existence of MCF2 raises more questions than it does answers. "We still ha
'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A unique arrangement for egg cell division
2. A study reveals how cells communicate to activate the cell division machinery
3. Newly created cancer stem cells could aid breast cancer research
4. Newly-identified exercise gene could help with depression
5. Newly defined signaling pathway could mean better biofuel sources
6. Newly identified role for power plants in human cells could lead to targeted therapies
7. New, more direct pathways from outside the cell-to-cell nuclei discovered
8. New continent and species discovered in Atlantic study
9. Ancient organisms discovered in Canadian gold mine
10. New golden frog discovered in remote region of Colombia
11. Antioxidant to retard wrinkles discovered by Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, a ... Internet of Things (IoT), today announced the appointment of ... operating officer. Previously a strategic advisor to the firm, ... operations. Mr. Traynor is based out of the C-Labs ... reports to Chris Muench , Chief Executive Officer. ...
(Date:11/18/2014)...   News Highlights: ... The Partners Data Lake, an agile data and ... will allow researcher and clinicians to explore and ... lives of patients , The Partners Data ... the Partners system, breaking down physical barriers for ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... b3c newswire / - Cambridge Healthtech Institute’s Fifth ... 27-29, 2009 at the Loews Philadelphia Hotel, Philadelphia, ... is April 10, 2009. , The signature event ... World Congress 2009 ( www.biomarkerworldcongress.com ) is dedicated ...
... MIT engineers and colleagues have observed the initiation of a ... animals in this case, fish. The work, conducted ... conservation of marine ecosystems that vast oceanic fish shoals inhabit," ... Science . It also confirms theories about the behavior ...
... fast bite spelled doom for bony fishes during the last ... study to be published March 31, 2009, in the ... Today, those same features characterize large predatory bony fishes, such ... at risk of extinction themselves, said Matt Friedman, author of ...
Cached Biology News:CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda 2CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda 3CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda 4CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda 5Team IDs genesis of mass migrations 2Team IDs genesis of mass migrations 3Study unravels why certain fishes went extinct 65 million years ago 2Study unravels why certain fishes went extinct 65 million years ago 3
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market ... Administration (FDA) for the use of Medtronic,s SynchroMed ... a newly developed catheter) for use with United ... to patients with pulmonary arterial hypertension.   ...
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , ... manufacturer and marketer of proprietary clinical grade hypothermic ... precision thermal shipping products for cells and ... will hold its 2015 Annual Meeting of Stockholders on ... the expected date for the Annual Meeting represents a ...
(Date:12/24/2014)... 2014 Earlier this year in a ... director of the Adult Stem Cell Technology Center, LLC ... and under appreciated unique property of adult tissue stem ... Cells: Misunderstood in the Past, Important for the Future,” ... He gave the address at the 4th World ...
(Date:12/24/2014)... According to Ross Selinger, President of ... Global, the national office market continues to be strong, driven ... evidenced by the third quarter’s surprising 3.9% GDP, unemployment decreasing ... costs have held inflation down and the Fed is keeping ... market remaining soft. , This solid economic news is having ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
...  Grifols, S.A. (NASDAQ: GRFS ) ... based in Barcelona, Spain today announced that on ... Talecris Biotherapeutics Holdings Corp. ("Talecris").  In partial consideration ... shares that trade in the U.S. as Grifols ...
... Masimo (NASDAQ: MASI ) today announced that its ... 31st Annual Growth Stock Conference at the Four Seasons Hotel in ... live audiocast of the presentation will be available on the Masimo ... be available following the live presentation. About ...
... for creating single-crystal arrays of the material graphene, an ... silicon in high-performance computers and electronics. The work by ... cover of the June issue of Nature Materials ... was first fabricated in 2004. Single-crystal arrays of the ...
Cached Biology Technology:Grifols Announces the Completion of its Acquisition of Talecris and the Listing of its ADSs on NASDAQ 2Masimo to Present at William Blair & Company 31st Annual Growth Stock Conference 2University of Houston develops method for creating single-crystal arrays of graphene 2
... adds two new Stem Cell Antibody Panels ... products. The Human Embryonic Stem Cell Marker ... antibodies against: alkaline phosphatase, Nanog, Oct-3/4, SSEA-1 ... Marker Antibody Panel Plus (Catalog # SC009) ...
... Printing Surface (3 glass slides coated with 100 /500/1000 ... wafer coated with 1000 Angstroms of Gold over TI ... (3 PDMS micropatterned stamps with series of 100 / ... or 200 um x 10 mm lines, 3 PDMS ...
...
Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss P...
Biology Products: