Navigation Links
'David and Goliath' viruses shed light on the origin of jumping genes: UBC study
Date:3/3/2011

University of British Columbia researchers have identified a small virus that attacks another virus more than 100 times its own size, rescuing the infected zooplankton from certain death. The discovery provides clues to the evolutionary origin of some jumping genes found in other organisms.

The study, by UBC marine microbiologist Curtis Suttle and PhD student Matthias Fischer, is published online today in Science Express. It describes the marine virus Mavirus and its interaction with marine zooplankton Cafeteria roenbergenesis and CroV, the world's largest marine virus.

"It's a microbial version of the David and Goliah story where, after infecting Cafeteria roenbergeneis, Mavirus protects it against infection by CroV, while ensuring its own survival," says Suttle.

Viruses rely on host cells to replicate; in the case of Mavirus, its host is another virus, making it only the second known virophage. It needs CroV to replicate, and in the process suppresses the propagation of CroV.

"What makes this interaction significant to evolutionary biology is that the closest genetic relatives to Mavirus are mobile genetic elements found in single-celled and higher organisms," says Suttle. "This implies that over evolutionary time, organisms have co-opted the DNA from ancient relatives of Mavirus into their own genomes, presumably so that they could acquire immunity against giant viruses like CroV.

Transposons, or jumping genes, are bits of DNA that can move or "transpose" themselves to new positions within an organism's genome. Researchers have suspected that a subset of transposons called Maverick transposons have a viral origin because of the nature of their DNA sequences.

Suttle and Fischer's latest work on Mavirus provides the first concrete evidence of this connection.

"Because they've sequestered the virophage DNA into their own genomes, organisms probably don't need to rely on being infected by a second virus to protect themselves," says Suttle.

Suttle and Fischer previously identified CroV as the world's largest marine virus, with a complex genome that has made it remarkably independent of its host cells.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. Filmmakers Joel and Ethan Coen among 2011 Dan David Prize winners
2. UMCES fisheries biologist Dr. David Secor receives USM Regents Faculty Award for research
3. Leader in genetics, Dr. David L. Rimoin, receives ACMG Foundation Lifetime Achievement Award
4. U of As David Schindler confirms untold levels of oil sands pollution on the Athabasca
5. American Society for Microbiology honors David Masopust for research on T cell memory
6. David Rose to present Howe School lecture on new technologies and business models, Jan. 29
7. Protein folding researcher David Baker to receive Sackler Prize in Biophysics
8. David Salt is worth his salt, says Science magazine
9. Using artificial, cell-like honey pots to entrap deadly viruses
10. Drug to fight tumors also fights the flu and possibly other viruses
11. Macavity wasnt there! How absent reoviruses kill cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/30/2017)... -- Trends, opportunities and forecast in this market to ... AFIS, iris recognition, facial recognition, hand geometry, vein recognition, ... industry (government and law enforcement, commercial and retail, health ... and by region ( North America , ... , and the Rest of the World) ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... JOHNSTON, Iowa (PRWEB) , ... October 12, 2017 ... ... company based in Vilnius, Lithuania, announced today that they have entered into a ... collaboration is to provide CRISPR researchers with additional tools for gene editing across ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, will ... analytical testing are being attributed to new regulatory requirements for all new drug ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity ... for performing systematic gain-of-function studies. , This complement to loss-of-function studies, such ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
Breaking Biology Technology: