Navigation Links
Data suggest liver experts should take care when prescribing novel antiviral HCV drugs
Date:4/2/2011

Berlin, Germany, Saturday 02 April 2011: Data presented at the International Liver CongressTM highlight the fact that new novel antiviral compounds for the treatment of hepatitis C virus (HCV) must be prescribed and monitored by experts and specialists to ensure resistance is minimised.1,2,3,4,5,6

Several studies observed the rapid onset of HCV resistance in patients treated with NS3-protease, NS5b-polymerase and NS5a inhibitors. Although these direct anti-virals are effective in both treatment-naive HCV patients and those who've been previously unresponsive to current treatment options, the development of resistant viral variants may cause problems in the future. In fact, two studies found HCV strains resistant to novel antiviral compounds pre-existed in patients who had never previously been exposed to the new antiviral compounds. In these patients, the variants were selected out by treatment.

Professor Heiner Wedemeyer, EASL's Secretary General, said: "While the regulatory approval of these new treatments is a highly anticipated milestone in HCV therapy, these studies show that care must be taken in the prescription and use of the new compounds. What we want to avoid is a rapid spread of HCV resistance within the patient population, which could drastically lower the effectiveness of the new drugs."

The current standard of care for chronic HCV is the combination of pegylated interferon-alfa and ribavirin, but only 40-54% of patients infected with HCV genotype 1 achieve a sustained virological response (SVR).7,8 Novel antiviral therapeutics are much sought after to treat patients who don't respond to the current standard of care. As such, a large number of new drugs for HCV are at various stages of preclinical and clinical development.9

However, as each new copy of the HCV genome exhibits on average one nucleotide change per replication cycle, HCV's replication machinery allows the virus to quickly come up with mutations that render it resistant to antiviral drugs. This is a major concern for successful anti-HCV therapy.10

NS3 protease inhibitors block the function of the HCV NS3 protease, an enzyme essential for HCV's replication. NS5A replication complex inhibitors block the function of HCV nonstructural protein 5A, a multifunctional protein essential for HCV replication.10


'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-784-306-9451
European Association for the Study of the Liver
Source:Eurekalert

Related biology news :

1. CU-Boulder study suggests air quality regulations miss key pollutants
2. Models of eel cells suggest electrifying possibilities
3. Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
4. NJIT professors research suggests changes in underwater data communications
5. Seasonal affective disorder may be linked to genetic mutation, study suggests
6. Revised theory suggests carbon dioxide levels already in danger zone
7. Shrimp trawling may boost mercury in red snapper, study suggests
8. Discovery of new gene associated with diabetes risk suggests link with body clock
9. Purdue study suggests warmer temperatures could lead to a boom in corn pests
10. Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests
11. Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... LIVERMORE, Calif. , March 21, 2017 ... recognition analytics company serving law enforcement agencies, announced today ... Sheridan as director of public safety business development. ... of diversified law enforcement experience, including a focus on ... Vigilant. In his most recent position, Mr. Sheridan served ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
(Date:3/2/2017)... 2, 2017 Summary This report provides ... its partnering interests and activities since 2010. ... Read the full report: ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... Denmark , March 22, 2017  Ascendis ... utilizes its innovative TransCon technology to address significant ... financial results for the full year ended December ... significant year for our company as we broadened ... a leading, integrated rare disease company with an ...
(Date:3/22/2017)... , March 22, 2017 The ... states a research report by Transparency Market Research (TMR). ... Amgen Inc., and AbbVie Inc., accounted for a share ... prominent players in this market are focusing aggressively on ... portfolio, which is likely to lead to market consolidation ...
(Date:3/22/2017)... ... March 21, 2017 , ... Premier executive recruitment firm, Slone ... Search Firm by Hunt Scanlon Media. , Hunt Scanlon Media is one ... widely referenced global news source in the human capital sector. , “It is a ...
(Date:3/22/2017)... ... 21, 2017 , ... The Conference Forum has announced the launch of the ... May 10-11, 2017, at the Colonnade Hotel in Boston, MA. The CMO Summit is ... learning, benchmarking and support. , “The Chief Medical Officer faces a unique set of ...
Breaking Biology Technology: