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Data acquisition and coordination key to human microbiome project
Date:6/9/2010

. GenePRIMP stands for "Gene PRediction IMprovement Pipeline, and it consists of a series of computational units that can be used to significantly improve the overall quality of the predicted genes in any sequenced genome. The results identify gene-calling errors such as potentially incorrect gene start and end positions, large overlaps between genes, and fragmented or missed genes. GOLD provides comprehensive information on genome sequencing projects, including metagenomes and metadata from around the world. The HMP project catalog is powered by the GOLD database and provides a specialized user interface by which the data stored in GOLD can be read.

The other co-principal investigator of the DACC is Victor Markowitz who heads Berkeley Lab's Biological Data Management and Technology Center in the Computational Research Division, and also serves as the Chief Informatics Officer and Associate Director at JGI. Markowitz oversees the development and maintenance of the Integrated Microbial Genomics with Microbiome samples (IMG/M) system, which provides comparative analysis tools for the study of metagenomes the collective genetic material of a given microbiome. First released in 2006, IMG/M contains millions of annotated microbial gene sequences, recovered from wild varieties of microbial communities. IMG/M is now being applied to the HMP.

"Resources such as GenePRIMP, GOLD and IMG/M are among the best in the world when it comes to providing comparative analysis tools for microbial genomes and metagenomes," Markowitz says. "As the HMP moves forward, these resources will provide support for the annotation and analysis of HMP datasets, in particular via the metagenome annotation pipeline at JGI and a HMP specific version of the IMG/M system."

The first 178 reference microbial genomes have now been analyzed and catalogued by the HMP. The results were published in the journal Science in a paper titled, "A Catalog of Reference Genomes from
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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

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