Navigation Links
Dartmouth researchers show effects of low dose arsenic on development

HANOVER, NH -- A team of Dartmouth Medical School (DMS) researchers has determined that low doses of arsenic disrupt the activity of a hormone critical in development. The finding is further evidence that arsenic at low doses (at levels found in U.S. drinking water in some areas) can be harmful. The study appeared in the Oct. 26, 2007, online edition of the journal Environmental Health Perspectives (EHP), and it will be published in a forthcoming issue of the journal.

"Arsenic is a natural, yet pervasive, chemical in the environment; we can't seem to escape it," says Joshua Hamilton, one of the authors on this study and the director of the Center for Environmental Health Sciences at Dartmouth and Dartmouth's Superfund Basic Research Program on Toxic Metals. "By learning how it adversely affects biological processes and at what levels we should be concerned, we will hopefully someday be able to mitigate its impact on human health." Hamilton is also a professor of pharmacology and toxicology at DMS.

Hamilton and his team, in previous work, have learned that arsenic at low doses appears to suppress the ability of all critical steroid receptors, including those for estrogen and testosterone, to respond to their normal hormone signals. Chemicals that disrupt steroid hormone receptor signaling are called endocrine disruptors. Arsenic can disrupt these hormone pathways at extremely low doses equivalent to what many people in the U.S. have in their drinking water.

This study set out to see whether arsenic can also disrupt the activity of two hormone receptors that are involved in normal development - the retinoic acid receptor and the thyroid hormone receptor, two important members of the larger nuclear hormone receptor family. While the researchers studied the impact on frog development, these two hormone receptors are also vital to human development.

"I believe this is the first demonstration in an animal model that arsenic actually disrupts a developmental process that is regulated by hormones, and it does this at extremely low doses that are directly relevant to human exposures of concern," says Hamilton.


Contact: Sue Knapp
Dartmouth College

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
(Date:11/10/2015)... , Nov. 10, 2015 ... biometrics that helps to identify and verify the ... is considered as the secure and accurate method ... of a particular individual because each individual,s signature ... results especially when dynamic signature of an individual ...
(Date:11/4/2015)... 4, 2015 --> ... published by Transparency Market Research "Home Security Solutions Market - ... 2015 - 2022", the global home security solutions market is expected ... 2022. The market is estimated to expand at a ... to 2022. Rising security needs among customers at homes, ...
(Date:10/29/2015)... Oct. 29, 2015  The J. Craig Venter Institute ... "DNA Synthesis and Biosecurity: Lessons Learned and Options for ... Health and Human Services guidance for synthetic biology providers ... --> --> Synthetic ... the potential to pose unique biosecurity threats. It now ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... ... Global Stem Cells Group announced the opening of a new core patient care hub ... northern Chile. The facilities are part of GSCG’s expansion efforts in Latin America. , ... cell medicine to patients from around the world. , The clinics will be headed by ...
(Date:11/30/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), a leader in ... Business Act on Climate Pledge, alongside more than 140 companies ... Obama Administration to demonstrate an ongoing commitment to climate action ... COP21 Paris climate negotiations. ... Canada . --> BioAmber uses biotechnology to ...
(Date:11/30/2015)... 2015  Culprits beware, a University at Albany ... Halámek, is taking crime scene fingerprint identification to ... -->   --> ... --> --> Halámek and his ... straightforward concept for identifying whether a culprit is ...
(Date:11/30/2015)... , Nov. 30, 2015 /PRNewswire/ - Zenith Epigenetics Corp. ("Zenith" ... Norman C.W. Wong to its Board of Directors ... to Zenith with a wealth of experience as co-founder of ... biology. --> --> Dr. ... Epigenetics, board of directors. Zenith,s long standing expertise in epigenetics ...
Breaking Biology Technology: