Navigation Links
Dartmouth researchers show effects of low dose arsenic on development
Date:11/14/2007

HANOVER, NH -- A team of Dartmouth Medical School (DMS) researchers has determined that low doses of arsenic disrupt the activity of a hormone critical in development. The finding is further evidence that arsenic at low doses (at levels found in U.S. drinking water in some areas) can be harmful. The study appeared in the Oct. 26, 2007, online edition of the journal Environmental Health Perspectives (EHP), and it will be published in a forthcoming issue of the journal.

"Arsenic is a natural, yet pervasive, chemical in the environment; we can't seem to escape it," says Joshua Hamilton, one of the authors on this study and the director of the Center for Environmental Health Sciences at Dartmouth and Dartmouth's Superfund Basic Research Program on Toxic Metals. "By learning how it adversely affects biological processes and at what levels we should be concerned, we will hopefully someday be able to mitigate its impact on human health." Hamilton is also a professor of pharmacology and toxicology at DMS.

Hamilton and his team, in previous work, have learned that arsenic at low doses appears to suppress the ability of all critical steroid receptors, including those for estrogen and testosterone, to respond to their normal hormone signals. Chemicals that disrupt steroid hormone receptor signaling are called endocrine disruptors. Arsenic can disrupt these hormone pathways at extremely low doses equivalent to what many people in the U.S. have in their drinking water.

This study set out to see whether arsenic can also disrupt the activity of two hormone receptors that are involved in normal development - the retinoic acid receptor and the thyroid hormone receptor, two important members of the larger nuclear hormone receptor family. While the researchers studied the impact on frog development, these two hormone receptors are also vital to human development.

"I believe this is the first demonstration in an animal model that arsenic act
'/>"/>

Contact: Sue Knapp
sue.knapp@dartmouth.edu
603-646-3661
Dartmouth College
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/21/2010)... dig in to your next stack of French toast or ... , That,s because University of Rhode Island researcher Navindra Seeram, ... 20 compounds in maple syrup from Canada that have been ... in maple syrup. In addition, eight of the compounds have ... time. , The URI assistant professor of biomedical and pharmaceutical ...
(Date:3/21/2010)... March 21, 2010 ─ (BRONX, NY) ─ Researchers at ... found two novel ways of killing the bacteria that ... two million deaths each year. The findings, published in ... Biology , could lead to a potent TB therapy ... , "This approach is totally different from the way ...
(Date:3/18/2010)... This release is available in Spanish . ... pigs as part of their regular diet makes them less ... Agricultural Research Service (ARS) scientists and cooperators. , The tryptophan-enhanced ... pigs during the 8-month study. Tryptophan, which is only acquired ...
Breaking Biology News(10 mins):URI pharmacy researcher finds beneficial compounds in pure maple syrup 2URI pharmacy researcher finds beneficial compounds in pure maple syrup 3Einstein researchers discover 2 new ways to kill TB 2Tryptophan-enriched diet reduces pig aggression 2New hope for deadly childhood bone cancer 9735 1New hope for deadly childhood bone cancer 9735 2CRESTOR 28R 29 Reduced Risk of Cardiovascular Events in Elderly Patients in New Analysis of Jupiter 4920 1CRESTOR 28R 29 Reduced Risk of Cardiovascular Events in Elderly Patients in New Analysis of Jupiter 4920 2CRESTOR 28R 29 Reduced Risk of Cardiovascular Events in Elderly Patients in New Analysis of Jupiter 4920 3CRESTOR 28R 29 Reduced Risk of Cardiovascular Events in Elderly Patients in New Analysis of Jupiter 4920 4CRESTOR 28R 29 Reduced Risk of Cardiovascular Events in Elderly Patients in New Analysis of Jupiter 4920 5Rib X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram negative Bac 13736 1Rib X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram negative Bac 13736 2Rib X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram negative Bac 13736 3
... the world,s oceans down a rapid spiral, and only ... reverse the catastrophic problems they are facing. , Such ... oceanography at Scripps Institution of Oceanography at UC San ... and their ecological health. Publishing his study in the ...
... When you make a new material on a nano scale ... team lead by a Biotechnology and Biological Sciences research Council ... major challenge faced by nanotechnology scientists. With new research ... from the University of Liverpool, The School of Pharmacy (University ...
... Ind. - Researchers have harnessed the sensitivity of days-old ... a range of harmful chemicals. , By measuring rates ... to contaminants and stressful conditions, the technology could reveal ... they cause more obvious and substantial harm. It could ...
Other Biology News:Oceans on the precipice: Scripps scientist warns of mass extinctions and 'rise of slime' 2Oceans on the precipice: Scripps scientist warns of mass extinctions and 'rise of slime' 3Scientists overcome nanotech hurdle 2Scientists overcome nanotech hurdle 3Using live fish, new tool a sentinel for environmental contamination 2Using live fish, new tool a sentinel for environmental contamination 3
(Date:3/18/2010)... International, Inc. (OTC Bulletin Board: MDFI), a leader in portable electronic medical records management, announced today the addition of internationally-renowned biotechnology veteran Dr. Gurinder Shahi , M.D., Ph.D., to ... ... ... ...
(Date:3/18/2010)... , ... cellular image manipulation software, Voxel Tracker™ is first-of-its-kind , ... Pittsburgh, PA (Vocus) March 18, 2010 ... for merging scanner images. The software, dubbed Voxel Tracker™, was designed to optimize ...
(Date:3/17/2010)... 18, 2010 As world population growth and dietary shifts continue, Monsanto Company,s (NYSE: ... than ever before, Brett Begemann , executive vice president – seeds and traits, will ... choices will help farmers around the world meet growing global demand for grain. , ... ...
(Date:3/17/2010)... single atom thicknow appears to be a promising base ... the National Institute of Standards and Technology (NIST) and ... graphene layers could potentially store hydrogen safely for use ... become something of a celebrity material in recent years ...
Breaking Biology Technology:MedeFile Adds International Biotech Expert to Advisory Board 2MedeFile Adds International Biotech Expert to Advisory Board 3MedeFile Adds International Biotech Expert to Advisory Board 4MedeFile Adds International Biotech Expert to Advisory Board 5Novel Imaging Software Released by Celsense Inc. 2Novel Imaging Software Released by Celsense Inc. 3Continued Demand Makes Monsanto and Agriculture Unique Investment Opportunities, Global Seeds and Traits Lead to Tell Investors 2Continued Demand Makes Monsanto and Agriculture Unique Investment Opportunities, Global Seeds and Traits Lead to Tell Investors 3Continued Demand Makes Monsanto and Agriculture Unique Investment Opportunities, Global Seeds and Traits Lead to Tell Investors 4Continued Demand Makes Monsanto and Agriculture Unique Investment Opportunities, Global Seeds and Traits Lead to Tell Investors 5Continued Demand Makes Monsanto and Agriculture Unique Investment Opportunities, Global Seeds and Traits Lead to Tell Investors 6Layered graphene sheets could solve hydrogen storage issues 2
... and JERSEY CITY, New Jersey, November 3, Rosetta ... in,the development of microRNA-based diagnostics, announced today it ... Bridging the Lab and Clinic in Cancer Medicine" ... will take place,between November 3-6, at the ICC ...
... Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ) a ... prescription,drugs for the treatment of drug addiction and ... Chief Executive,Officer, will be presenting an overview of ... Global Investment Conference on Tuesday, November 11,2008 at ...
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ONCY) ... in its U.K. combination REOLYSIN(R) and docetaxel clinical ... Pandha of the Royal Surrey Hospital, U.K., presented ... of Cancer,(iSBTC) annual meeting on November 1, 2008. ...
Other Biology Technology:Rosetta Genomics to Present at the American Association of Cancer Research (AACR) Centennial Conference 2Rosetta Genomics to Present at the American Association of Cancer Research (AACR) Centennial Conference 3Catalyst Pharmaceutical Partners to Present at the Rodman & Renshaw 10th Annual Global Investment Conference 2Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 2Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 3Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 4
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
Umbilical cord blood mononuclear cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Biology Products: