Navigation Links
Dartmouth researchers identify potential therapeutic target for deadly brain cancer
Date:4/8/2014

(Lebanon, NH, 4/8/14) Researchers from the Geisel School of Medicine at Dartmouth will present a scientific poster on Tuesday, April 8, 2014 at the American Association of Cancer Researchers conference in San Diego, CA. The research identifies a potential characteristic for predicting outcome in a deadly form of brain cancer known as glioblastoma multiforme.

Existing therapies based on genetic information have failed to effectively treat glioblastomas. Therefore, researchers are aggressively looking to find new molecular targets for this aggressive brain tumor.

Dartmouth researchers previously demonstrated that STK17A is a protein that is induced when DNA is damaged by the chemotherapeutic drug cisplatin. Biopsied samples of glioblastoma tumors contain high level of STK17A. And the more STK17A a tumor has the poorer the outcome appears to be. Increased levels of STK17A are correlated with shorter survival time for glioblastoma patients.

In addition, when researchers tried to "turn off" the STK17A protein, they observed a reduced rate of cancer cell growth. Reducing STK17A also interfered with tumor cells' ability to move around and invade other areas of the brain.

Further investigation is required to understand the precise role of STK17A in glioblastoma, but the finding may reveal a potential Achilles' Heel for this deadly type of brain tumor that often times seems unstoppable.


'/>"/>

Contact: Robin Dutcher
robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth
Source:Eurekalert

Page: 1

Related biology news :

1. Dartmouth researchers find promising results with local hyperthermia of tumors
2. Dartmouth-led research shows temperature, not snowfall, driving tropical glacier size
3. Dartmouth study shows US Southwest irrigation system facing decline after 4 centuries
4. Dartmouth researchers develop new tool to identify genetic risk factors
5. Dartmouth-led team gets $8 million grant to research arsenic in children
6. Dartmouth-led study shows diet alone can be significant source of arsenic
7. Dartmouth-led team discovers how plants avoid sunburn
8. Dartmouth researchers find there is no single sexy chin
9. Dartmouth researchers invent real time secondhand smoke sensor
10. Dartmouth neuroscientist finds free will has neural basis
11. Dartmouth research offers new control strategies for bipolar bark beetles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... amount of death at the right time might actually ... research that could help in understanding animal populations, pest ... a paper in the journal Trends in Ecology ... colleagues conclude that the kind of positive population effect ... or mortality, depends on the size and developmental stage ...
(Date:11/4/2014)... Think about the way our bodies are assembled during ... that they are supposed to become a nerve or ... the correct place and alignment? Researchers at the University ... In a new study, UM researchers describe the signaling ... neighbors, at the head-trunk region. Their discovery may have ...
(Date:11/4/2014)...   3D scanner developer targets ... Fuel3D , a developer of 3D scanning solutions, today announced ... (£4 million). This funding builds on the company,s initial $2.6 ... the way for the commercial launch of the company,s consumer ... led by Chimera Partners and will be used to ramp-up ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2The inside story: How the brain and skull stay together 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... NANO -- World,s smallest antenna . . . ... metal or dipole antenna, electronic devices of tomorrow could incorporate ... possible by a design that allows an electrically charged nano-mechanical ... be the days when we need to match the antenna ...
... the day a machine can draw your blood, screen it ... and pop out a drug tailor-made for your DNA. ... point irregularities which have accumulated over time that can lead ... National Institutes of Health has tapped Viterbi professor Andrea Armani ...
... Finally, a gazelle comes into view. The cheetah plunges forward, ... the hapless gazelle by the jugular in less than a ... A blue whale surfaces, blasting water high from its ... with air. Then it descends again to look for krill, ...
Cached Biology News:Story tips from the US Department of Energy's Oak Ridge National Laboratory October 2010 2Story tips from the US Department of Energy's Oak Ridge National Laboratory October 2010 3Fighting cancers by tagging their triggers 2Slicing proteins with Occam's Razor 2Slicing proteins with Occam's Razor 3Slicing proteins with Occam's Razor 4
(Date:11/21/2014)... 20, 2014 Polaris Group announced today ... its Phase 1 trial of ADI-PEG 20 in ... of malignant pleural mesothelioma (MPM) and non-squamous non-small ... trials on ADI-PEG 20, both as monotherapy and ... of several other indications, including breast cancer, melanomas, ...
(Date:11/21/2014)... SAN DIEGO , Nov. 20, 2014  Cytori Therapeutics ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com ... 4, 2014 TIME:    11:15 am PT / 2:15 ... this URL into your browser,s address bar: http://bit.ly/1B2KGaL ... time and receive event updates. This will ...
(Date:11/18/2014)... SAN BRUNO, Calif. , Nov. 18, 2014 ... is a platinum sponsor of the 10th Annual World Stem ... and regenerative medicine stakeholders. The 2014 World Stem Cell Summit ... San Antonio, Texas . ... the discovery and development of lifesaving cures and therapies, convening ...
(Date:11/18/2014)... 17, 2014 Cirrascale Corporation ... blade-based and rackmount computing infrastructure, today announced it ... accelerator throughout its GPU-enabled blade server and high-performance ... company’s latest proprietary 80-lane Gen3 PCIe switch-enabled risers, ... Tesla K80 dual-GPU accelerator cards in a single ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3
... Stemedica ... of clinical grade biological products as licensed by the State of California Food and Drug ... latest scientific discoveries at the 2009 World Stem Cell Summit. , ... San Diego, CA (PRWEB) Aug 27, 2009 -- ...
... , The statement below is from Pete Nicholas, Chairman ... employees and its Board of Directors. , , ... remarkably broad spectrum of issues. Foremost among them was his long and ... , He was a tireless advocate for patients, rights and for ...
... , CHICAGO, Aug. 26 Ajinomoto Food ... adding food product development capabilities. The Application Center North America ... , The ACNA mission is to develop and ... technology applications will be the initial focus of the Center: ...
Cached Biology Technology:Stemedica Selected By World Stem Cell Summit To Present Scientific Discoveries 2Stemedica Selected By World Stem Cell Summit To Present Scientific Discoveries 3Stemedica Selected By World Stem Cell Summit To Present Scientific Discoveries 4Boston Scientific Statement on the Passing of Senator Edward Kennedy 2
Request Info...
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
Rabbit polyclonal to Somatostatin 28 ( Abpromise for all tested applications). entrezGeneID: 6750 SwissProtID: P61278...
... is an essential component of the COP9 ... various cellular and developmental processes. The CSN ... ubiquitin (Ubl) conjugation pathway by mediating the ... E3 ligase complexes. The complex is also ...
Biology Products: