Navigation Links
Dartmouth researchers find the root of the evolutionary emergence of vertebrates
Date:2/11/2008

HANOVER, N.H. Dartmouth College researchers and colleagues from the University of Bristol in the U.K. have traced the beginnings of complex life, i.e. vertebrates, to microRNA. The researchers argue that the evolution of microRNAs, which regulate gene expression, are behind the origin of early vertebrates.

This study not only points the way to understanding the evolutionary origin of our own lineage, but it also helps us to understand how our own genome was assembled in deep time, says Kevin Peterson, an author on the paper and an associate professor of biological sciences at Dartmouth.

Their study was published on February 11, 2008, issue of the Proceedings of the National Academy of Sciences.

Peterson worked with Dartmouth graduate student Alysha Heimberg, Vanessa Moy, a Dartmouth biology research assistant, and Lorenzo Sempere, a researcher with Dartmouth Medical School. Philip Donoghue of Bristol Universitys Department of Earth Sciences was also a co-author. They showed that microRNAs, a class of tiny molecules only recently discovered residing within what has usually been considered junk DNA, are hugely diverse in even the most lowly of vertebrates, but relatively few are found in the genomes of our invertebrate relatives.

There was an explosive increase in the number of new microRNAs added to the genome of vertebrates and this is unparalleled in evolutionary history, says Heimberg.

The team studied the genomics of primitive living fishes, such as sharks and lampreys, and their spineless relatives, like the sea squirt. By reconstructing the acquisition history of microRNAs shared between human and mice, the researchers determined that the highest rate of microRNA innovation in the vertebrate lineage occurred before the divergence between the living jawless fishes like the lamprey and the jawed fishes like the shark, but after the divergence of vertebrates from their invertebrate chordate relatives, such as the sea squirt.

Co-author Donoghue adds, Most of these new genes are required for the growth of organs that are unique to vertebrates, such as the liver, pancreas and brain. Therefore, the origin of vertebrates and the origin of these genes is no coincidence.


'/>"/>

Contact: Sue Knapp
sue.knapp@dartmouth.edu
603-646-3661
Dartmouth College
Source:Eurekalert

Related biology news :

1. Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem
2. Dartmouth researchers show effects of low dose arsenic on development
3. Researchers decode genetics of rare photosynthetic bacterium
4. Researchers decode genetics of rare photosynthetic bacteria
5. Stevens researchers provide oversight for three-year mariculture program in Egypt and Israel
6. Hot springs microbes hold key to dating sedimentary rocks, researchers say
7. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
8. Tiny genetic differences have huge consequences: McGill researchers
9. MNI researchers locate neurological basis of depression following sports concussion
10. Researchers reveal HIV peptides possible pathway into the cell
11. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:5/24/2016)... -- Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the ... latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Display- Ampronix News ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... enabling healthier lives through the development of innovative products ... the United States denied its ... the claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 ... criteria established by the Supreme Court,s Mayo Collaborative Services ...
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
Breaking Biology Technology: