Navigation Links
Dartmouth researchers find promising results with local hyperthermia of tumors
Date:3/4/2014

A combination of iron-oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumors in mice according to an accepted manuscript by Dartmouth-Hitchcock Norris Cotton Center researchers in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.

"The study demonstrates that controlled heating of one tumor can stimulate an immune response that attacks another tumor that has not had the heat treatment," said Steve Fiering, PhD, Norris Cotton Cancer Center researcher and professor of Microbiology and Immunology, and of Genetics at the Geisel School of Medicine at Dartmouth. "This is one way to try to train the immune system to attack metastatic tumors that may not be recognized yet."

Researchers injected iron-oxide nanoparticles into the tumor and then activated those agents with magnetic energy. Researchers were able to activate antigen-presenting dendritic cells in the body's immune system. Dendritic cells somewhat serve as "quarterbacks" for body's immune system by calling for quick coordinated protection against an attack. The "quarterback" cells show the defensive "killer" T cells (CD8+ cells) who to attack and these cells then directly attack tumor cells and send out an alert system to engage other cells in the fight against the cancer. The combination of these two aspects of the immune response reduce risk of recurrence and discourage spreading or metastasis of the cancer. This result was observed in sites close to the primary tumor as well as distant sites. In the experiments conducted as part of this study the primary tumor resisted regrowth for one month following overheating.

The magnetic hyperthermia system used was developed by co-author P. Jack Hoopes, DVM, PhD co-director of Norris Cotton Cancer Center's Nanotechnology Working Group. "It enables very precise control of the heating to keep the tempe
'/>"/>

Contact: Donna Dubuc
donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Dartmouth-led research shows temperature, not snowfall, driving tropical glacier size
2. Dartmouth study shows US Southwest irrigation system facing decline after 4 centuries
3. Dartmouth researchers develop new tool to identify genetic risk factors
4. Dartmouth-led team gets $8 million grant to research arsenic in children
5. Dartmouth-led study shows diet alone can be significant source of arsenic
6. Dartmouth-led team discovers how plants avoid sunburn
7. Dartmouth researchers find there is no single sexy chin
8. Dartmouth researchers invent real time secondhand smoke sensor
9. Dartmouth neuroscientist finds free will has neural basis
10. Dartmouth research offers new control strategies for bipolar bark beetles
11. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dartmouth researchers find promising results with local hyperthermia of tumors
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
(Date:4/6/2015)... Conn. , Apr. 6, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/143028 for ... COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces a ... payments. This patent surrounds the use of miniature ...
(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Revises Revenues for Q1 2015 2
... to degraded air quality in 2050 if man-made emissions continue ... 40 years from now will experience similar air pollution to ... those of a study published today in Atmospheric Chemistry ... Geosciences Union (EGU). Air pollution is a major health ...
... have announced a major joint initiative in environmental ... will provide a world-class research and training centre ... molecular biology, including DNA sequencing, metabolomics and bioinformatics. ... change through to disease susceptibility and treatment. ...
... growth have been identified in sediment-laden marine environments, conditions previously ... has established that Middle Reef part of Australia,s iconic ... other reefs in areas with lower levels of sediment stress. ... an international team of scientists is published today (1 August ...
Cached Biology News:Cut emissions further or face risks of high air pollution, study shows 2Cut emissions further or face risks of high air pollution, study shows 3BGI partners with the University of Birmingham 2BGI partners with the University of Birmingham 3Coral reef thriving in sediment-laden waters 2
(Date:5/5/2015)... VIEW, Calif. , May 5, 2015  23andMe, ... launch of the Lupus Research Study in ... 5,000 individuals with systemic lupus erythematosus, more commonly known ... the genetics of lupus. The effort is also in ... with Lupus Awareness Month in May. Approximately ...
(Date:5/5/2015)... 2015 Psyche Systems Corporation and Luminate Health ... first-of-its-kind platform that helps labs comply with new federal ... the way patients engage with these results, and improves ... provides a HIPAA-compliant digital platform that gives labs an ... their lab results, and uniquely connects labs, physicians, and ...
(Date:5/5/2015)... LOS ANGELES , May 5, 2015 ... and pioneer in providing on-demand access to scientific, technical ... purchasing agreement with the Association of Southeastern Research ... of 38 research libraries located across 11 southeastern states. ... developing innovative and collaborative programs to address the continually ...
(Date:5/5/2015)... Franz Inc ., the leading supplier ... its flagship product, AllegroGraph, has been named a Champion by ... report. AllegroGraph is a high performance Semantic Graph ... Graph databases are skyrocketing in popularity and have grown by ... DBMS ranking by DB-Engines. , “We are excited ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3
... /Xinhua-PRNewswire-FirstCall/ -- Benda,Pharmaceutical, Inc. (OTC Bulletin Board: ... a commercialized gene,therapy medicine for the treatment ... today filed an amendment to the Company,s ... Commission ("SEC"). The,amendment covers the resale by ...
... N.J., May 6 Genta,Incorporated (Nasdaq: GNTA ... from the NASDAQ Listing Qualifications Panel that the ... compliance with the,minimum stockholders, equity requirement for continued ... also determined that de-listing from,The NASDAQ Capital Markets ...
... Life,Sciences, Inc. (Nasdaq: CALP ) today announced ... Health Care Conference in Boston,Massachusetts, will be webcast ... Kevin,Hrusovsky, President and CEO of Caliper, will be ... webcast can be accessed at, http://www.corporate-ir.net/ireye/confLobby.zhtml?ticker=CALP&item_id=18275 ,63. An ...
Cached Biology Technology:Benda Pharmaceutical Files Amendment To Form S-1 2Genta Announces Pending Transfer of its Common Stock to the Over-the-Counter Bulletin Board 2Genta Announces Pending Transfer of its Common Stock to the Over-the-Counter Bulletin Board 3
Fujifilm BAS-1800II provides the ideal configuration for a low-cost imager that requires only a small amount of space in the laboratory. The small imager for accurate high-throughput screening...
When added to StemSep T Cell Enrichment cocktail, human TCRab TAC is designed to deplete human TCRab from samples to isolate gd T cells....
... 384 is a compact and self-contained ... is a unique flow-through device, which ... included wash system. Optional refill ... system. Will be upgradable to ...
... The Eclipse C1 Plus is a ... highest-quality digital imaging with an ultra-compact and ... of the C1 Plusboost optical performance to ... acquisition.The system alsoincludes support for X and ...
Biology Products: