Navigation Links
Dartmouth researchers find new protein function
Date:1/9/2009

HANOVER, NH A group of Dartmouth researchers has found a new function for one of the proteins involved with chromosome segregation during cell division. Their finding adds to the growing knowledge about the fundamental workings of cells, and contributes to understanding how cell function can go wrong, as it does with cancerous cells.

The researchers studied a protein called NOD, distantly related to the motor proteins that power diverse cellular activities, including intracellular transport, signaling, and cell division. They used X-ray crystallography to determine its structure, and then they used enzyme kinetics to find out how it performed. While this protein is found in fruit flies, the results are helpful in determining how related proteins work in humans.

"This study on NOD provided evidence for a new way a kinesin motor could function," said Jared Cochran, a postdoctoral fellow at Dartmouth and the lead author on the study. "Rather than moving on its own, it hitches a ride on the ends of microtubules which results in a dynamic cross-linking between the arms of chromosomes and the cell's growing spindle of microtubules. If NOD doesn't function properly, then the two cells end up with either both or none of that particular chromosome, which is lethal [to the cell and the organism] in most cases."

With colleagues from Lawrence Berkeley National Laboratory, Stowers Institute for Medical Research in Kansas City, Missouri, and Kansas University Medical Center in Kansas City, Kansas, the Dartmouth group published their study in the Jan. 9, 2009, issue of the journal Cell. Their paper is titled, "ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement."

"Before this study, it had been shown that kinesin motors either walked along their microtubule tracks or functioned to break microtubules apart," says Jon Kull, the senior author on the paper, associate professor of chemistry at Dartmouth, and a 1988 Dartmouth graduate. "This work describes a novel mode for kinesin function, in which NOD does not walk, but rather alternates between grabbing on to and letting go of the end of the growing filament, thereby tracking the end as it grows. The diversity of function of these proteins is remarkable."

One of the authors on the paper, Natasha Mulko, is a 2007 Dartmouth graduate, and worked on this project as her senior honors thesis in chemistry. Mulko is currently a graduate student in dentistry at Creighton University. "Natasha's work was integral to this study as she worked on obtaining and improving the protein crystals necessary to solve the structure," says Kull, her thesis advisor.


'/>"/>

Contact: Sue Knapp
sue.knapp@dartmouth.edu
603-646-3661
Dartmouth College
Source:Eurekalert

Related biology news :

1. Dartmouth workshop sets research agenda for environmental mercury
2. Dartmouth awarded NSF grant for new polar sciences, engineering grad program
3. Dartmouth researchers identify an important gene for a healthy, nutritious plant
4. Dartmouth researchers discover gene signatures for scleroderma
5. Dartmouth researchers find the root of the evolutionary emergence of vertebrates
6. Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem
7. Dartmouth researchers show effects of low dose arsenic on development
8. Burnham researchers discover on switch for cell death signaling mechanism
9. Salk researchers develop novel glioblastoma mouse model
10. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
11. The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... --  WaferGen Bio-systems, Inc. (NASDAQ: WGBS ... that on December 13, 2016, it received a letter ... Market LLC which acknowledged that, as of December 12, ... had been at $1.00 or greater for ten consecutive ... Rule 5550(a)(2) of the Nasdaq Stock Market. ...
(Date:12/15/2016)... 2016 Advancements in biometrics will ... and wellbeing (HWW), and security of vehicles ... passenger vehicles begin to feature fingerprint recognition, ... beat monitoring, brain wave monitoring, stress detection, ... pulse detection. These will be driven by ...
(Date:12/15/2016)... Dec. 14, 2016 "Increase in mobile transactions ... The mobile biometrics market is expected to grow from ... by 2022, at a CAGR of 29.3% between 2016 ... as the growing demand for smart devices, government initiatives, ... "Software component is expected to grow at a ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... CALABASAS, Calif. , Jan. 19, 2017 /PRNewswire/ ... Mathias Schmidt , Ph.D., as chief executive ... board of directors. Dr. Schmidt brings to ArmaGen more ... on the research and development of biotherapeutics and ... biopharmaceutical executive with the diverse experience and skillset ...
(Date:1/19/2017)... ... January 19, 2017 , ... DaVita ... full spectrum of drug and device development, and Prism Clinical Research , ... clinicians, today announced Verified Clinical Trials (VCT) has been selected by ...
(Date:1/18/2017)... ... 2017 , ... Opal Kelly, a leading producer of powerful ... the ZEM5310 USB 3.0 FPGA Module, combining a SuperSpeed USB 3.0 interface and ... suitable for prototyping, testing, and production-ready integration. The ZEM5310 USB interface delivers real-world ...
(Date:1/18/2017)... ... ... Executive search firm Slone Partners proudly supports the SCOPE ... of the clinical trials segment. Hosted in Miami, this conference brings together renowned ... , As executive talent specialists in the industries central to clinical trials, ...
Breaking Biology Technology: