Navigation Links
Dartmouth researchers discover gene signatures for scleroderma
Date:7/15/2008

"Since no one understands the basic processes that cause scleroderma, it has been largely categorized by the distribution of clinical findings, such as the location of skin thickening (torso relative to the hands). These studies, utilizing objective measures, establish that distinct genetic programs account for the ways this disease manifests itself and hold out the possibility for an improved ability to treat and induce remission of this potentially fatal disease," adds Rigby, who is a professor of medicine and of microbiology and immunology.

The work continues a longtime collaboration with Dr. Kari Connolly at the University of California, San Francisco, which has a large scleroderma patient population. It builds on a map of skin that Whitfield and colleagues created using gene expression -- which genes are turned on-- to delineate differences among scleroderma patients beyond obvious symptoms.

The map was based on skin samples from patients with diffuse scleroderma, the most severe form of the disease, and healthy controls. Two skin samples were taken from each patient: one from affected skin in the forearm, and another from an unaffected lower back area, which though seemingly healthy, also showed aberrant genes, demonstrating the disease was truly systemic when the biopsies were taken.

The new research is considered the largest scleroderma gene expression study to date. The investigators analyzed gene activity in 28 patients with varying types of scleroderma and six healthy control subjects, using skin biopsies from an arm and back.

Whitfield compares the molecular classification to how breast and other cancers have been characterized. "Our goal was to go into a disease of completely different etiology, but plagued by similar problems of clinical heterogeneity and to quantify disease subsets at the gene expression level."

The researchers used DNA mircoarrays to measure gene expression and computational alg
'/>"/>

Contact: Hali Wickner
hali.wickner@dartmouth.edu
Dartmouth Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dartmouth researchers find the root of the evolutionary emergence of vertebrates
2. Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem
3. Dartmouth researchers show effects of low dose arsenic on development
4. Louisiana Tech researchers feature drug reformulation in prestigious journal
5. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
6. Researchers catch ion channels in their opening act
7. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
8. Researchers hack final part of the immune system code
9. Iowa State researchers study ground cover to reduce impact of biomass harvest
10. From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
11. Researchers reveal types of genes necessary for brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... /PRNewswire-iReach/ -- The IEEE Engineering in Medicine and Biology ... International Conference (EMBC,14), this year being held at the ... Illinois , from Tuesday, August 26 through Saturday, ... industry professionals in science, medicine, and engineering are registered ... This year,s conference theme is ...
(Date:8/27/2014)... as giant, frightening beasts. But every creature is a ... slab containing fossils of 24 very young dinosaurs and ... hatchlings overseen by a caretaker, according to a new ... P. Hedrick and Peter Dodson led the work, collaborating ... where the specimen is held. Hedrick is a doctoral ...
(Date:8/27/2014)... release is available in German . ... is the most common inherited disease affecting the peripheral ... the Max Planck Institute of Experimental Medicine and University ... Schwann cells is impaired in rats with the disease. ... layer known as myelin, which facilitates the rapid transfer ...
Breaking Biology News(10 mins):Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3Potential therapy for incurable Charcot-Marie-Tooth disease 2
... A current controversy raging in evolutionary biology is ... many genes, each of relatively small effect, or just ... published in Molecular Ecology strongly supports the ... from the Department of Biology and the Redpath Museum, ...
... Robot squirrels from the University of California, Davis, ... a research project on the interaction between squirrels and ... how squirrels signal to snakes with heat and tail ... University and UC Davis aim to learn more about ...
... April 3, 2012 A team led by scientists ... prevent infection from widely differing strains of hepatitis C virus ... very high rate of mutation normally helps it to evade ... to sites on the viral envelope that seldom mutate. One ...
Cached Biology News:Robosquirrels versus rattlesnakes 2Robosquirrels versus rattlesnakes 3Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 2Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 3Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 4
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
(Date:8/27/2014)... “We are honored to be named to this ... of Radiant Sage. “We are offering truly ground-breaking clinical ... market to a different level. We are enabling ... and effectively manage the massive amounts of medical imaging ... read by trained physicians. Being recognized by technology industry ...
(Date:8/27/2014)... , Aug. 27, 2014 Guggenheim Securities, the ... today announced the hiring of veteran equity analyst Charles ... analyst. Mr. Butler will focus on the biotech/biopharma sector. ... a wealth of experience and a broad network of ... Senior Managing Director and Head of Equities at Guggenheim ...
(Date:8/27/2014)... LONDON , Aug. 27, 2014 ... The Graphene Opportunity - A Rational ... Is Graphene The New Nanotech? A similar ... predictions of applications ranging from microelectronics to water ... today announced the availability of the Graphene Opportunity ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... QED International Associates, Inc.,administrator for the ... fund portfolios, today announced that effective at ... 2008, Alexion Pharmaceutical, Inc.,(Nasdaq: ALXN ) ... ASPV ) in,the HealthShares(TM) Autoimmune-Inflammation Index. Alpharma, ...
... ARLINGTON, Va., Jan. 4 Faced with ... suppliers are turning their attention to,opportunities in ... navigate these unfamiliar waters, leading research and,advisory ... report,examining the marketing and media preferences of ...
... Md., Jan. 4 Human Genome Sciences,Inc. (Nasdaq: ... 26th,Annual JPMorgan Healthcare Conference will be webcast and may ... ), A member of Human Genome Sciences, ... on Wednesday, January 9, 2008 at 7:30 am Pacific,Time, ...
Cached Biology Technology:QED International Associates Announces Changes to the HealthShares(TM) Autoimmune-Inflammation and Neuroscience Indexes - Correction 2Study Examines Media Preferences of Life Scientists in Applied Markets 2Study Examines Media Preferences of Life Scientists in Applied Markets 3
...
MSE ANTI CAN. CD3:FITC/RAT ANTI CD4:RPE...
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
Biology Products: