Navigation Links
Dartmouth researchers discover gene signatures for scleroderma
Date:7/15/2008

"Since no one understands the basic processes that cause scleroderma, it has been largely categorized by the distribution of clinical findings, such as the location of skin thickening (torso relative to the hands). These studies, utilizing objective measures, establish that distinct genetic programs account for the ways this disease manifests itself and hold out the possibility for an improved ability to treat and induce remission of this potentially fatal disease," adds Rigby, who is a professor of medicine and of microbiology and immunology.

The work continues a longtime collaboration with Dr. Kari Connolly at the University of California, San Francisco, which has a large scleroderma patient population. It builds on a map of skin that Whitfield and colleagues created using gene expression -- which genes are turned on-- to delineate differences among scleroderma patients beyond obvious symptoms.

The map was based on skin samples from patients with diffuse scleroderma, the most severe form of the disease, and healthy controls. Two skin samples were taken from each patient: one from affected skin in the forearm, and another from an unaffected lower back area, which though seemingly healthy, also showed aberrant genes, demonstrating the disease was truly systemic when the biopsies were taken.

The new research is considered the largest scleroderma gene expression study to date. The investigators analyzed gene activity in 28 patients with varying types of scleroderma and six healthy control subjects, using skin biopsies from an arm and back.

Whitfield compares the molecular classification to how breast and other cancers have been characterized. "Our goal was to go into a disease of completely different etiology, but plagued by similar problems of clinical heterogeneity and to quantify disease subsets at the gene expression level."

The researchers used DNA mircoarrays to measure gene expression and computational alg
'/>"/>

Contact: Hali Wickner
hali.wickner@dartmouth.edu
Dartmouth Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dartmouth researchers find the root of the evolutionary emergence of vertebrates
2. Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem
3. Dartmouth researchers show effects of low dose arsenic on development
4. Louisiana Tech researchers feature drug reformulation in prestigious journal
5. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
6. Researchers catch ion channels in their opening act
7. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
8. Researchers hack final part of the immune system code
9. Iowa State researchers study ground cover to reduce impact of biomass harvest
10. From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
11. Researchers reveal types of genes necessary for brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Feb. 3, 2015 Despite a ... from industries such as consumer electronics, automotive, storage ... surface mount technology (SMT) screen printers. Innovations in ... control will push the adoption curve up. Meanwhile, ... steady as glue dispensers are indispensable in the ...
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
(Date:1/22/2015)... Wis. , Jan. 15, 2015  BellBrook Labs, ... drug discovery, announced the launch of a TR-FRET ... the company,s Transcreener UDP Assay, a high throughput ... The new assay will allow for sensitive detection ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... trees, which are a main resource for desert people ... hyper-arid Eastern Desert of Egypt. , In places more ... 1965 and 2003, while almost no new trees have ... tree mortality seems not to be climate, but commercial ...
... nocturnally migrating songbirds, while venturing into the unfamiliar night ... at least release anti-predator vigilance thanks to the concealment ... scientists ?published this week in PLoS ONE ?shows that ... passerines. , A unique creature is indeed capable ...
... found on the islands of Borneo and Sumatra is an ... originally thought to be the same species as the one ... conducted at the U.S. National Cancer Institute shows that the ... the differences between other large cat species like lions, tigers, ...
Cached Biology News:Bats prey on nocturnally migrating songbirds 2Bats prey on nocturnally migrating songbirds 3Bats prey on nocturnally migrating songbirds 4New species declared: Clouded leopard on Borneo and Sumatra 2
(Date:3/4/2015)... In an article published and posted online today, senior ... the clinical aspects of diseases caused by 5 major ... "Clinical Management of Potential Bioterrorism-Related Conditions," was published and ... New England Journal of Medicine . ... Inglesby—review the clinical management of conditions resulting from exposure ...
(Date:3/4/2015)... USDM Life Sciences , a ... industry, hired David Blewitt as Vice President ... Services and Solutions at USDM Life Sciences , which ... maintaining compliance with government regulations worldwide. , For ... life sciences regulatory and IS compliance professional with extensive ...
(Date:3/4/2015)... 4, 2015 /CNW/ - Resverlogix Corp. (TSX:RVX) (the ... a collaborative research program with Emerald Logic, ... Collective Evolution Technology (FACET), Emerald Logic analyzed ... obtained from each of 798 patients who ... trials ASSERT, SUSTAIN and ASSURE. The objective ...
(Date:3/4/2015)... March 4, 2015 AcelRx Pharmaceuticals, Inc. ... company focused on the development and commercialization of ... breakthrough pain, today announced that it will release ... market close on Monday, March 9th, 2015. AcelRx ... 4:30 p.m. Eastern Time (1:30 p.m. Pacific Time) ...
Breaking Biology Technology:Latest Clinical Information On Bioterrorism Threats 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... Fair Political,Practices Commission, SANTA MONICA, Calif., Nov. 21 ... resign from the board for,violating conflict of interest rules, ... Reed intervened and attempted to influence the awarding ... Burnham Institute, where Reed is,president and chief executive., ...
... Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) announced ... during the 19th Annual Piper Jaffray,Health Care Conference ... Eastern,Time. The presentation will be webcast from The ... the Investor Relations tab at http://www.alexza.com ,or ...
... Incorporated,(Nasdaq: VPHM ) today announced that Vincent ... of ViroPharma, will present,at the Lazard Capital Markets ... Tuesday, November 27, 2007. The conference is being ... also announced that Michel de Rosen, president and ...
Cached Biology Technology:California Stem Cell Board Member Violates Conflict Rules; Should Resign From Committee, Consumer Group Says 2California Stem Cell Board Member Violates Conflict Rules; Should Resign From Committee, Consumer Group Says 319th Annual Piper Jaffray Health Care Conference to Webcast Alexza's Corporate Presentation 2ViroPharma to Present at Two Upcoming Healthcare Conferences 2
Peptide-affinity Purified Polyclonal Antibody to Olfactory Receptor, Family 2, Subfamily H, Member 3...
Molecular Biological Resources offers bulk quantities of existing protein products. Please see the Chimerx divisions website for existing products and contact lloconne@molbiores.com for pricing....
... BalanceTalk collects data from balances and scales ... into any other program. If you can type ... the data collection process Simple to use ... to data , Add user information , Collect ...
Peptide-affinity Purified Polyclonal Antibody to Prolactin Releasing Hormone Receptor (GPR10)...
Biology Products: