Navigation Links
Dartmouth researchers discover gene signatures for scleroderma
Date:7/15/2008

Hanover, NH-- Distinct genetic profiles can discern different groups of patients with scleroderma, a vexing autoimmune disease in which the body turns against itself, Dartmouth Medical School researchers report. Their discovery of distinguishing molecular subtypes within the disease offers new insight into the complexity of a poorly understood and hard to treat illness and opens a window for better diagnosis and targeted therapies.

Scleroderma is a chronic connective tissue disorder that can cause skin hardening and internal organ dysfunction and affects four times as many women as men. It captures a range of related conditions, from mild, localized to the skin, to systemic and life threatening.

Patient complications are variable and hard to predict, explains Dr. Michael Whitfield, assistant professor of genetics at DMS, who headed the research team. "We show that we can divide the patients even more finely than what is currently done clinically, and found a clear association between disease severity and gene expression. " The results were published online, July 16 in PLoS ONE, an open-access journal of the Public Library of Science.

"We show for the first time that we can classify patients with a systemic autoimmune disease into different groups by gene expression patterns alone," says Whitfield "Now that we have discovered new subsets at the molecular level, we can begin to map the genetic pathways to see if we can we use these signatures to predict who will progress to different clinical endpoints." The researchers hope to begin to understand which patients should be treated aggressively, for example, and which drugs benefit which patients.

"Scleroderma constitutes one of the most mysterious of human diseases. The studies by the Whitfield group are particularly noteworthy as they constitute the first genetic categorization of scleroderma," says Dr. William Rigby, a DMS rheumatolgist who treats scleroderma.
'/>"/>

Contact: Hali Wickner
hali.wickner@dartmouth.edu
Dartmouth Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dartmouth researchers find the root of the evolutionary emergence of vertebrates
2. Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem
3. Dartmouth researchers show effects of low dose arsenic on development
4. Louisiana Tech researchers feature drug reformulation in prestigious journal
5. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
6. Researchers catch ion channels in their opening act
7. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
8. Researchers hack final part of the immune system code
9. Iowa State researchers study ground cover to reduce impact of biomass harvest
10. From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
11. Researchers reveal types of genes necessary for brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the ... Business Report" report to their offering. This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ...
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
(Date:3/23/2015)... March 23, 2015   HOYOS Labs , a ... today announced that the Company will demonstrate multiple biometrics-based ... and consumers at Connect:ID on March 23 through 25, ... Labs will highlight the IEEE Biometric Open Protocol Standard; ... and enterprise access control system. BOPS was invented by ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... of the Midwest is expected to result in the second-smallest ... to a University of Michigan forecast released today. The ... zone of about 1,200 square miles, an area the size ... replace 2000 (1,696 square miles) as the year with the ...
... the University of Calgary have developed a way for ... colour, face shape or fingerprintsand create a learning system ... from different sources. Marina Gavrilova, the founding head ... to introduce and study neural network based models for ...
... proteins by the Department of Biotechnology of Neiker-Tecnalia have ... tumor cell lines. This property shows that the latex ... easily acclimated, could be considered in clinical trials for ... has been done in collaboration with the University of ...
Cached Biology News:U-M forecasters predict second-smallest Gulf of Mexico 'dead zone' 2U-M forecasters predict second-smallest Gulf of Mexico 'dead zone' 3U-M forecasters predict second-smallest Gulf of Mexico 'dead zone' 4Researchers advance biometric security 2Neiker-Tecnalia identifies antitumour proteins in the latex of the plant Euphorbia trigona 2
(Date:5/1/2015)... , May 1, 2015 ... Genetic Technologies Ltd (NASDAQ: GENE ), Agilent ... Scientific Inc. (NYSE: TMO ), Sequenom Inc. ... PKI ). Free research report on Genetic ... On Thursday, April 30, 2015, the NASDAQ Composite ...
(Date:4/30/2015)... 2015 Spirax Sarco, the leader in ... to announce that for the first time in the ... of a Queen’s Award for Innovation – the UK’s ... manufacture of a unique flowmeter. , The Spirax Sarco ... traditional steam flow measurement. The device provides reliable, ...
(Date:4/30/2015)... MN , April 30, 2015 /PRNewswire/ - BioAmber ... producing sustainable chemicals, today announced that it has commenced an ... BioAmber expects to grant the underwriters a 30-day option ... the shares of common stock offered in the public ... there can be no assurance as to whether or ...
(Date:4/30/2015)... MA & Budapest, Hungary (PRWEB) April 30, 2015 ... only web-based electronic lab notebook with integrated protocols ... in providing chemistry software solutions and consulting services ... led to the development of Labguru’s newest feature: ... set of deep domain features for biologists, bio-chemists, ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Spirax Sarco Receives a Queen’s Award for Innovation 2Spirax Sarco Receives a Queen’s Award for Innovation 3BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3Labguru Integrates ChemAxon's Marvin JS, to Enhance Functionality for Chemists 2
... computational tools and a state-of-the-art scanning transmission electron ... Iowa State University materials science and engineering researchers ... solid metallic materials known as metallic glasses. ... Review Letters , the findings fill a gap ...
... Richard Dolinar, chairman of the Alliance for Safe Biologic ... U.S. Food and Drug Administration (FDA) should resolve before ... in prepared testimony for the FDA,s May 11th public ... for the development of biosimilar products. ...
... May 10, 2012 Aviir Diagnostic Laboratory has entered ... as a participating provider with Stratose Network and their ... Stratose A true pioneer of claims ... PlanCare America, 4MOST Health, Qualident and KeyClaims) works to ...
Cached Biology Technology:In metallic glasses, researchers find a few new atomic structures 2In metallic glasses, researchers find a few new atomic structures 3Alliance for Safe Biologic Medicines Chairman Urges FDA to Ensure that Patient Safety is the Cornerstone of Biosimilar Pathway 2Aviir Laboratories Announce National Agreement with Stratose 2Aviir Laboratories Announce National Agreement with Stratose 3
... The FailSafe™ PCR System is the only ... first time and every time. It provides ... of the source or the property of ... FailSafe™ PCR Enzyme Mix, a unique blend ...
...
Bis-Acrylamide (bis) is a monomer used as a crosslinker with acrylamide to form polyacrylamide electrophoretic gels. This 2% bis solution is supplied as 500 ml....
... immunostaining ,This solution has effect on enhancing ... clearer signal than the one obtained by ... of secondary antibody used and exposure time ... have images with high S/N ratio and ...
Biology Products: