Navigation Links
Dartmouth researchers develop new tool to identify genetic risk factors
Date:1/30/2014

(Lebanon, NH, 1/30/14) Dartmouth researchers developed a new biological pathway-based computational model, called the Pathway-based Human Phenotype Network (PHPN), to identify underlying genetic connections between different diseases as reported in BioDataMining this week. The PHPN mines the data present in large publicly available disease datasets to find shared SNPs, genes, or pathways and expresses them in a visual form.

"The PHPN offers a bird's eye view of the diseases and phenotype's relationships at the systems level," said Christian Darabos, PhD, post-doctoral fellow, Institute for Quantitative Biomedical Sciences (iQBS), Dartmouth College.

The PHPN uses information in human disease networks in conjunction with network science tools to show clusters of related disorders sharing common genetic backgrounds. It does so without the typical clinical classification of disease, in which all heart disease or all cancers are grouped together, based on clinical presentation. Dartmouth geneticists instead rely on the information contained in the PHPN's topology to automatically classify traits and diseases by their shared genetic mechanisms, such as common genes or pathways. PHPN explores the connections between the layers of the networks to find patterns and relationships.

"The intuitive network representation of the knowledge mined from several large-scale datasets makes the information accessible to anyone. It lies at the crossroads of computational genetics, systems biology, information theory, and network science," Darabos said.

PHPN supports the integration of genomic and phenotypic data to uncover significant links between traits, attributes, and disease. This offer tremendous potential in identifying risk factors for certain diseases. At the same time, it can reveal important targets for therapeutic intervention.

"As a proof of concept, the PHPN has proven capable of identifying well documented interactions, and many novel links that remain to be explored in depth," said Darabos.

The PHPN reveals biological connections between seemingly disparate displays of genetic properties and offers a unique view of the architecture of disease.

This tool can help researchers identify areas for further investigation based on connections it uncovers. "The PHPN is a hypothesis-generating tool, potentially capable of identifying yet uncharacterized common drug targets," said Darabos.

As a next step, iQBS researchers will refine statistical methods, isolate networks for optimal results, and compare previous work on phenotype networks.


'/>"/>
Contact: Donna Dubuc
Donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth
Source:Eurekalert  

Related biology news :

1. Dartmouth-led team gets $8 million grant to research arsenic in children
2. Dartmouth-led study shows diet alone can be significant source of arsenic
3. Dartmouth-led team discovers how plants avoid sunburn
4. Dartmouth researchers find there is no single sexy chin
5. Dartmouth researchers invent real time secondhand smoke sensor
6. Dartmouth neuroscientist finds free will has neural basis
7. Dartmouth research offers new control strategies for bipolar bark beetles
8. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
9. Dartmouth research: The clocks are ticking and the climate is changing
10. Science stars head to Dartmouth for the E.E. Just Symposium
11. Dartmouth research imparts momentum to mobile health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dartmouth researchers develop new tool to identify genetic risk factors
(Date:1/4/2017)... Jan. 4, 2017  For the thousands of attendees at this year,s ... in connected health and biometric measurement devices and services, will be featuring ... On display in A&D Medical,s special CES Exhibit Suite , the ... expansion of the company,s WellnessConnected product platform.  ... ...
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
(Date:12/16/2016)... 16, 2016 The global wearable medical device market, in ... 2021 from USD 5.31 billion in 2016, at a CAGR of ... ... technological advancements in medical devices, launch of a growing number of ... connectivity among healthcare providers, and increasing focus on physical fitness. ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Jose, CA (PRWEB) , ... January 17, 2017 , ... ... cultivate a balanced, peaceful and healthy lifestyle, announced today the official launch of its ... and frees the mind. , In development for over a year, the ...
(Date:1/17/2017)... ... January 17, 2017 , ... NeoTrident, a leading provider ... and performance management systems for high-consequence industries, announced today that they have entered ... sciences industry, organizations must pay much more attention to the quality of products ...
(Date:1/17/2017)... , Jan. 17, 2017  Protagonist Therapeutics, ... that it has initiated a global Phase 2b ... oral peptide that targets alpha4beta7 integrin. The aim ... is to evaluate the safety/tolerability and efficacy of ... with moderate to severe active disease. ...
(Date:1/16/2017)... ... January 16, 2017 , ... Appellate ... its decision on the appeal filed by India-based Dishman Pharmaceutical & Chemical Ltd. ... against DPCL and one of its Dishman Group’s 100% wholly owned New Jersey-based ...
Breaking Biology Technology: