Navigation Links
Dartmouth-led team gets $8 million grant to research arsenic in children
Date:1/16/2014

The Children's Environmental Health and Disease Prevention Research Center at Dartmouth and its partner universities have received an $8 million grant to expand their research into arsenic toxicity in children and pregnant women.

The five-year grant is jointly funded by the National Institute of Environmental Health Sciences (part of the National Institutes of Health) and the U.S. Environmental Protection Agency. Dartmouth leads the multidisciplinary effort in collaboration with Stanford University, Harvard Medical School and the University of Miami. About 15 percent of the grant will support the work of these collaborators. Center members specialize in environmental, nutritional and molecular epidemiology, public health, pediatrics, ecology, nutrition, bioinformatics, biomedical informatics, trace element analysis and other fields.

"With the expansion of the center, we can deepen our understanding of environmental exposure to common contaminants such as arsenic during fetal development and childhood and the impact these exposures have on childhood immunity, growth and neurobehavioral development," says Professor Margaret Karagas, director of the Center and a professor at Dartmouth's Geisel School of Medicine.

The Center builds on a Dartmouth study begun in 2009 of pregnant New Hampshire women, whose private wells may contain elevated arsenic levels. The long-term health of their children will be evaluated. The Center's research will focus on three projects:

  • Investigating the effects of arsenic exposure on mothers and infants and their susceptibility to allergies and infection.
  • Quantifying arsenic exposure through water and food during infancy and early childhood and determining its impact on growth and neurobehavioral development.
  • Examining epigenetic and gene expression changes in the placenta in relation to arsenic exposure and health effects.

The center, in its pilot phase, discovered that certain foods, including rice and rice products, contribute to arsenic exposure in children, and it recently reported findings of increased infection risk in children (Environmental Research, 2013) and changes in DNA in umbilical cord blood (Environmental Health Perspectives, 2013) and placental tissue, relating to low birth weight (Environmental Health, 2013), associated with in utero arsenic exposure. The Center also recently reported that diet alone can be a significant source of arsenic exposure regardless of arsenic concentrations in drinking and cooking water.

Karagas says that the center's mission is to identify and address key emerging issues related to health impacts of early life environmental exposures. "There is growing research connecting exposure early in life to a number of prevalent and life threatening diseases for children," she says. "Moreover, early life exposures and their effects also appear to extend beyond childhood."

Evidence suggests that environmental exposure may affect the development of the immune system, and in turn infant risk of emerging diseases such as allergies and asthma, she says. Diseases known or suspected to be caused by or aggravated by arsenic in drinking water include various cancers as well as cardiovascular disease.

"Additionally, risk of obesity, which has greatly increased in prevalence in both children and adults, is influenced by factors occurring early in life," says Karagas. "Therefore, if environmental contaminants increase early life growth, they will heighten risk for obesity which is a major risk factor for cardiovascular disease and cancer."


'/>"/>

Contact: John Cramer
John.Cramer@Dartmouth.edu
603-646-9130
Dartmouth College
Source:Eurekalert  

Related biology news :

1. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
2. Dartmouth-led team discovers how plants avoid sunburn
3. Dartmouth-led study shows diet alone can be significant source of arsenic
4. Oceans acidifying faster today than in past 300 million years
5. Autism Speaks awards $1.1 million to fund high priority studies
6. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
7. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
8. University leads £6 million EU project to tackle obesity
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. 17th century Dutch explorers help the Atlas reach a major milestone -- 30 million records
11. Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dartmouth-led team gets $8 million grant to research arsenic in children
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
(Date:6/22/2016)... , June 22, 2016   StockNewsNow.com , The ... Interview with Dr. Nader Pourhassan , President & ... focused on the clinical development and potential commercialization of ... HIV infection, according to the company,s website (see here: ... Tuesday, June 7 th , 2016, at the LD ...
(Date:6/22/2016)... DIEGO , June 22, 2016  Mesa ... has developed a testing platform designed specifically for ... formation of their scientific advisory board (SAB). Approved ... directors, the SAB is chartered to advise on ... disease assay platform. Led by Dr. Steve ...
Breaking Biology Technology: