Navigation Links
Dantrolene protects neurons from Huntington's disease
Date:11/24/2011

Huntington's disease (HD) is characterized by ongoing destruction of specific neurons within the brain. It affects a person's ability to walk, talk, and think - leading to involuntary movement and loss of muscle co-ordination. New research published in BioMed Central's open access journal Molecular Neurodegeneration shows that the RyanR inhibitor Dantrolene is able to reduce the severity of walking and balance problems in a mouse model of HD.

Progressive damage to medium spiny neurons (MSN) in the brain of a person with HD is responsible for many of the symptoms and is caused by an inherited recessive mutation in the gene 'Huntingtin'. The mutated version of this protein leads to abnormal release of calcium from stores within the neurons which in turn disrupts the connections between neurons firing and muscle contractions, and eventually kills the neurons.

Researchers from the University of Texas Southwestern Medical Center tested Dantrolene, a muscle relaxant which works by stabilizing calcium signaling, and showed that this drug could prevent calcium-dependent toxicity in laboratory grown neurons. The team led by Dr Ilya Bezprozvanny also found that Dantrolene could prevent destruction of co-ordination, measured by beam walking and footprint patterns, in mice with Huntington's-like disease.

Dr Bezprozvanny explained, "One of the features of HD mice is the progressive loss of their NeuN-positive neurons. Dantrolene was not only able to protect muscle co-ordination in mice with HD but also prevented destruction of NeuN positive neurons. Our results suggest that RyanR inhibitors, such as Dantrolene, should be considered as future treatments to slow down the effects of diseases like Huntington's."


'/>"/>
Contact: Dr Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Bird flu vaccine protects people and pets
2. Flu shot protects kids -- even during years with a bad vaccine match
3. New national park protects worlds rarest gorilla
4. A protein that protects against Alzheimers?
5. Scientists discover how deadly fungus protects itself
6. Scientists identify key gene that protects against leukemia
7. Device protects transplanted pancreatic cells from the immune system
8. Study reveals how one form of natural vitamin E protects brain after stroke
9. BBS proteins shown to run an export business that protects cilia
10. OHSU researchers discover cellular mechanism that protects against disease
11. Enzyme deficiency protects hepatitis C patients from treatment-related anemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... to survive? The answer changes depending on climate, and some ... sprouts. Stanford researchers have found that the formation of ... meaning mouth) is controlled by a specific signaling pathway that ... The findings are described in a paper published Nov. 14 ...
... Nov. 24 M2SYS Technology, an award-winning,fingerprint ... that,InvoTech Systems Inc., the leading provider of ... industry, has chosen M2SYS Technology to,provide ... software and with M2SYS, M2-EasyScan(TM) optical fingerprint,reader. ...
... (NIST) announced today that it is awarding grants totaling ... cost-shared support for the construction of new scientific research ... in a special competition announced last spring. The ... the University of California at Berkeley for the build-out ...
Cached Biology News:Key link in how plants adapt to climate discovered by Stanford researchers 2InvoTech Selects M2SYS Technology for Leading-Edge Fingerprint Software Solution 2NIST awards $24M in grants for new research facilities 2NIST awards $24M in grants for new research facilities 3NIST awards $24M in grants for new research facilities 4NIST awards $24M in grants for new research facilities 5
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)... Jan. 22, 2015   Cypher Genomics, Inc., ... (NASDAQ: SQNM ), the leading molecular ... next generation noninvasive prenatal tests (NIPT). Through this ... called Mantis™, to advance analysis of clinically-relevant fetal ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2
... February 29, 2012 TREM Rx, Inc., a biotechnology ... to the skin, announced today the results of an in ... powerful cells of the immune system called TREMs (T Resident ... protective immune response that is far stronger than memory T ...
... has been shown to significantly improve the chances of pregnancy ... a Newcastle team of fertility experts at the University and ... a totally enclosed and controlled environment within which every step ... published today in the journal PLoS ONE reveals ...
... 2012 ARUP Laboratories, a leading national clinical and ... laboratory research and development, announced the establishment of a ... ) The new division is designed to ... enhance our ability to diversify into new market segments. ...
Cached Biology Technology:Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 2Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 3Increased fertility rate for IVF patients achieved by new equipment design 2ARUP Laboratories Announces Creation of Business Innovations Division 2
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
B3GALT2 Immunogen: B3GALT2 (NP_003774, 324 a.a. ~ 423 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
... ( Abpromise for all tested applications). ... KLH derived from within residues 500 to the ... acid sequence is proprietary) (Peptide ... Entrez Gene ID: 51043 ...
Rabbit polyclonal to SUR1 ( Abpromise for all tested applications). Antigen: Synthetic peptide Entrez Gene ID: 6833 Swiss Protein ID: Q09428...
Biology Products: