Navigation Links
Danish researchers predict risk of valvular heart disease
Date:11/12/2013

Researchers at the University of Copenhagen, Herlev Hospital and Rigshospitalet have identified a clear link between narrowed heart valves and a special lipoprotein in the blood. In the long term, the research may well help to prevent valvular heart disease. The new findings have just been published in the Journal of the American College of Cardiology.

Aortic valve stenosis (AS) in which the opening of the aortic valve is narrowed affects 2-7% of the Danish population aged over 65 years. The disease can be fatal, and the only effective treatment at the moment is valve surgery. The condition can be inherited.

Danish researchers predict risk of valvular heart disease

Researchers at the University of Copenhagen, Herlev Hospital and Rigshospitalet have identified a clear link between narrowed heart valves and a special protein in the blood. In the long term, the research may well help to prevent valvular heart disease. The new findings have just been published in the Journal of the American College of Cardiology.

Aortic valve stenosis (AS) in which the opening of the aortic valve is narrowed affects 2-7% of the Danish population aged over 65 years. The disease can be fatal, and the only effective treatment at the moment is valve surgery. The condition is often inherited.

"Based on extensive population surveys, we have shown that high levels of lipoprotein(a) in the blood constitute a significant risk factor for developing aortic stenosis in the general Danish population. Thus, the 10% of the population with the highest levels of lipoprotein(a) in their blood are two to three times more likely to develop the disease simply on these grounds," says Clinical Professor at the University of Copenhagen and consultant at Rigshospitalet, Anne Tybjrg-Hansen.

The researchers have also shown that the risk of developing aortic stenosis is greatest among people born with a special variant of the so-called LPA gene, a gene variation which means increased levels of lipoprotein(a) throughout a person's entire life. Genetic studies in Denmark support previous international research in the area which shows that the LPA gene plays a key role in the development of aortic stenosis.

Better prevention and fewer surgical interventions

The researchers are hoping that the new research findings can be used to help prevent demanding treatments for aortic stenosis in the population:

"In the short term, we are hoping that our research will inspire the pharmaceutical industry to conduct clinical trials which investigate the effect of reducing lipoprotein(a) levels in the body in relation to aortic stenosis and also coronary heart disease including coronary thrombosis. Previous studies suggest a causal relationship between blood clots and lipoprotein(a)," says Pia Rrbk Kamstrup, a consultant at Herlev Hospital, adding:

"Preventative treatments targeted at individuals with very high levels of lipoprotein(a) in their blood can hopefully reduce the number of patients requiring valve surgery and the risks always associated with surgical procedures."

The researchers took the Copenhagen General Population Study as their starting point. They had lipoprotein(a) measurements for approx. 29,000 participants, and studied the LPA gene of approx. 77,500 people. The participants were monitored for five years on average, but up to 20 years to monitor the development of aortic stenosis. For following up, the researchers used diagnoses from the Danish National Patient Register (Landspatientregistret) and the Cause of Death Register (Ddsrsagsregistret) as well as operation codes from the Danish Health and Medicines Authority's registers of surgical interventions including aortic valve surgery.


'/>"/>

Contact: Pia Rørbæk Kamstrup
Pia.Roerbaek.Kamstrup@regionh.dk
45-50-56-73-05
University of Copenhagen
Source:Eurekalert

Related biology news :

1. Danish researchers expose new cause of life-threatening disease
2. Danish researchers release ground-breaking knowledge about calcium pumps in cells
3. New Danish fungal species discovered
4. Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
5. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
6. Protein illustrates muscle damage: McMaster researchers
7. NSF awards to UT Arlington researchers will fuel sustainable solutions
8. Researchers uncover origins of cattle farming in China
9. UT Southwestern researchers identify how body clock affects inflammation
10. Researchers suggest plan to address hypoxia in Gulf of Mexico
11. Researchers advocate for climate adaptation science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
(Date:3/10/2016)... 10, 2016   Unisys Corporation (NYSE: UIS ... (CBP) is testing its biometric identity solution at the ... to help identify certain non-U.S. citizens leaving the country. ... designed to help determine the efficiency and accuracy of using ... and will run until May 2016. --> ...
(Date:3/8/2016)... March 8, 2016   Valencell , the ... announced it has secured $11M in Series D ... a new venture fund being launched by UAE-based ... from existing investors TDF Ventures and WSJ Joshua ... continue its triple-digit growth and accelerate its pioneering ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... ... May 02, 2016 , ... Meister ... mind, the fresh look and added functionality give the agricultural world a taste ... a dynamic shift in agriculture – from precision farming via satellites and Unmanned ...
(Date:4/29/2016)... Italy (PRWEB) , ... April 30, 2016 , ... The ... extraordinary textile design, the bioLogic team explored how bacterial properties can be applied to ... of using Natto bacteria, which move in response to humidity change. The team harvested ...
(Date:4/29/2016)... , April 29, 2016 ... Transparency Market Research "Separation Systems for Commercial Biotechnology ... Trends, and Forecast 2015 - 2023", the separation ... US$ 10,665.5 Mn in 2014 and is projected ... 2015 to 2023 to reach US$ 19,227.8 Mn ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Intelligent Implant ... by the FDA via 510(k) for sale in the United States. These components ... posterior thoraco-lumbar fusions. With one-level sales beginning in October of 2015, the company ...
Breaking Biology Technology: