Navigation Links
Danish researchers expose new cause of life-threatening disease
Date:6/7/2013

Danish researchers have just published findings that explain a previously unknown mechanism used by cells to communicate with one another. The research significantly contributes to understanding why some children are born with malformations and why children and adults may develop life-threatening diseases.

Dr. Sren Tvorup Christensen (Department of Biology) and Professor Lars Allan Larsen (Department of Cellular and Molecular Medicine) at the University of Copenhagen, in collaboration with colleagues in Denmark and France, have spearheaded the recent discovery which sheds new light on the causes of a range of debilitating diseases and birth defects.

Antennae-like structures on the surface of cells

Over the years, the research group has been a leader in primary cilium research. Primary cilia are antennae-like structures found on the surface of nearly all cells in the human body. These antennae are designed to receive signals, such as growth factor and hormones, from other cells in the body and then convert these signals to a response within individual cells. Defective formation or function of these antennae can give rise to a range of serious maladies including heart defects, polycystic kidney disease, blindness, cancer, obesity and diabetes. However, there remains a great deal of mystery as to how these antennae capture and convert signals within cells.

The groundbreaking results have been published in Cell Reports, a prestigious scientific journal. The research is supported by the Lundbeck Foundation, the Novo Nordisk Foundation and the Danish Heart Association (in Danish), among others.

"We have identified an entirely new way by which these antennae are able to register signals in their midst, signals that serve to determine how cells divide and move amongst one another. This also serves to explain how a stem cell can develop into heart muscle," explains Sren Tvorup Christensen.

Dr. Sren Tvorup Christensen

"What we have found is that the antennae don't just capture signals via receptors out in the antennae, but they are also able to transport specific types of receptors down to the base of the antennae - where they are then activated and might possibly interact with a host of other signalling systems. The receptors include the so-called Transforming Growth Factor beta (TGFβ) receptors which have previously been associated with birth defects and cancer. Therefore, the base of the antennae can serve as a sort of control centre that coordinates the cell's ability to manage foetal development and the maintenance of organ function in adults."

TGFβ signalling and development of the heart

Lars Allan Larsen has numerous years of experience in heart development research. He adds "we know TGFβ signalling is very important during heart development and that a failure in this system can lead to the congenital heart defects that affect roughly 1% of all newborns. Therefore, our discovery is a significant step towards demystifying the causes of congenital heart defects."

Professor Lars Allan Larsen

The two researchers also point out that defective TGFβ-signalling has been associated with neurodegenerative diseases such as Alzheimers, Parkinsons disease and mental retardation. Subsequently, the research group has begun studies on how these antennae - the primary cilia - regulate TGFβ-signalling during, among other processes, the transformation of stem cells into nerve cells.

"It's definitely an area that will be attracting lots of attention in years to come. Globally, there is a great deal of interest in understanding why the antennae are so important for our health," concludes the pair of researchers.


'/>"/>

Contact: Søren Tvorup Christensen
stchristensen@bio.ku.dk
45-51-32-29-97
University of Copenhagen
Source:Eurekalert

Related biology news :

1. New Danish fungal species discovered
2. Danish researchers release ground-breaking knowledge about calcium pumps in cells
3. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
4. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
5. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
6. UNH researchers find African farmers need better climate change data to improve farming practices
7. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
8. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
9. Researchers print live cells with a standard inkjet printer
10. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
11. Researchers reveal how a single gene mutation leads to uncontrolled obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
(Date:10/9/2017)... , ... October 09, 2017 , ... At its national ... Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has been ... a member of the winning team for the 2015 Breakthrough Prize in Fundamental physics ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography ... generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase ...
Breaking Biology Technology: