Navigation Links
Dangerous plaques in blood vessels rupture by overproducing protein-busting enzymes
Date:3/29/2010

fats, and other debris. UW researchers learned that, inside some advanced plaques, macrophages churn out an overload of protein-digesting enzymes.

In a mouse study, Dickek and his team transplanted bone marrow containing macrophages that overproduce a protein-digesting enzyme known as urokinase into aged, atherosclerotic mice. These macrophages accumulated in some of the plaques. Compared to atherosclerotic mice of the same age, atherosclerotic mice with macrophages in overdrive had a much greater prevalence (61 percent versus 13 percent) of hemorrhage inside the plaques as well as more disruption of the fibrous caps covering the plaques.

"These same features hemorrhage and cap disruption are associated with ruptured plaques that cause heart attacks and strokes in humans," Dichek noted.

Urokinase was already known to be abundant in ruptured human plaques.

"But automatically blaming urokinase as the culprit without experimental evidence that it destabilized otherwise stable plaques would have been like seeing bright red trucks and firefighters at every flaming building and assuming they had set the blazes," Dichek said "In fact urokinase does have a protective effect at the right place and the right time, and we use it therapeutically as a clot-buster."

The researchers also observed that the increase in urokinase upped the activity of other protein-digesting enzymes that can eat away at the structural proteins that hold a plaque together. These other enzymes can weaken the framework of the plaque and also promote the self-destruction of nearby smooth muscle cells in the artery. These enzymes belong to a large family of remodeling enzymes called matrix metalloproteinases, or MMPs. The exact form of MMP implicated in this study hasn't been determined. Like urokinase, MMPs have helpful roles, depending on the location and circumstances in the body.

Urokinase also activates a substance in blood v
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. CABI helps phase out dangerous pesticide in EU
2. Nicotine may accelerate atherosclerosis, may be as dangerous as tar
3. Dangerous liaisons
4. Dolphin therapy a dangerous fad, Emory researchers warn
5. Defining genes role may lead to prevention of dangerous corn toxin
6. A chilling glimpse inside the minds of dangerous criminals
7. Detecting dangerous chemicals with lasers, exploring the brains circuitry with light and more
8. Genetic breakthrough explains dangerously high blood glucose levels
9. Study shows mercury levels from products decreasing, though still at dangerous levels
10. Humans response to risk can be unnecessarily dangerous, finds Tel Aviv University study
11. Warming world in range of dangerous consequences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dangerous plaques in blood vessels rupture by overproducing protein-busting enzymes
(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and ... addition of the "Global Iris Recognition Market 2015-2019" ... forecast the Global Iris Recognition market to grow at ... This report covers the present scenario and ... for the period 2015-2019. To calculate the market size, ...
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... with critical security-authentication needs, today announced the beginning of ... (FFD) solution. The company, based in ... at the three-day Connect:ID Expo, which began here today ... NexID said version 2.0 of its SDK boosts the ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... Taking aim at a leading cause of ... at the Massachusetts Biologic Laboratories (MBL) of the University of ... that neutralizes the Hepatitis C virus (HCV). The new ... infection by the virus in a pre-clinical animal model of ...
... details of a membership agreement with BioMed Central to ... researchers. Pfizer,s BioMed Central membership arrangement means that ... researcher employed or funded by Pfizer when they submit ... peer-reviewed open access journals. By funding open access publication ...
... of Guam Associate Professor Laurie Raymundo is senior editor ... and management of coral diseases, " Coral Disease Handbook: ... summarizes the most recently developed methods for studying the ... the book is a set of identification cards for ...
Cached Biology News:Novel antibody prevents infection by hepatitis C virus 2Novel antibody prevents infection by hepatitis C virus 3
(Date:3/26/2015)... 26, 2015 The Market Element LLC, ... strategic alliance with Designing Gig LLC to provide website ... , “Forging this alliance with Designing Gig represents ... can extend a comprehensive, end-to-end, digital solution for our ... execution,” said Chuck Miller, president of The Market Element. ...
(Date:3/26/2015)... and CINCINNATI , March 26, ... SHP, NASDAQ: SHPG ) and Cincinnati Children,s ... research collaboration for rare diseases. The goal of the ... to treat rare diseases with high unmet medical ... Cincinnati Children,s research expertise. As a nationally ranked ...
(Date:3/26/2015)... 2015 PAREXEL International Corporation (Nasdaq: ... research organization , announced today that the ... acquire all of the business assets of privately-owned ... of specialized pharmacovigilance services, based in Chandigarh, ... assessment, monitoring, and prevention of adverse effects ...
(Date:3/26/2015)... March 26, 2015 "In America," the popular ... United States that is hosted by legendary film actor James ... of botany in an upcoming segment. , Botany is ... reality it is actually quite a bit more complicated than ... different types of living organisms, from the smallest bacteria known ...
Breaking Biology Technology:The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
... Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ) today ... months ended June 30, 2008., "We continue ... stated Patrick J. McEnany, Catalyst,s Chief Executive Officer.,"In ... in our U.S.,Phase II clinical trials evaluating CPP-109 ...
... TAIAN CITY, Shandong, China, Aug. 14 /Xinhua-PRNewswire-FirstCall/ --,China ... Biologic,",the "Company"), one of the leading plasma-based pharmaceutical ... reported financial results,for the second quarter ended June ... -- Revenues increased 35.1% year-over-year to $11.9 ...
... 14 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: CHBT) ... the manufacture,research, development, marketing and distribution of probiotics ... quarter of its 2009,fiscal year, ended June 30, ... -- Net sales increased 19.5% year-over-year to $11.4 ...
Cached Biology Technology:Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 2Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 4Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 5China Biologic Products Reports Second Quarter 2008 Results 2China Biologic Products Reports Second Quarter 2008 Results 3China Biologic Products Reports Second Quarter 2008 Results 4China Biologic Products Reports Second Quarter 2008 Results 5China Biologic Products Reports Second Quarter 2008 Results 6China Biologic Products Reports Second Quarter 2008 Results 7China Biologic Products Reports Second Quarter 2008 Results 8China Biologic Products Reports Second Quarter 2008 Results 9China Biologic Products Reports Second Quarter 2008 Results 10China Biologic Products Reports Second Quarter 2008 Results 11China Biologic Products Reports Second Quarter 2008 Results 12China Biologic Products Reports Second Quarter 2008 Results 13China Biologic Products Reports Second Quarter 2008 Results 14China Biologic Products Reports Second Quarter 2008 Results 15China-Biotics, Inc. Reports First Quarter 2009 Financial Results 2China-Biotics, Inc. Reports First Quarter 2009 Financial Results 3China-Biotics, Inc. Reports First Quarter 2009 Financial Results 4China-Biotics, Inc. Reports First Quarter 2009 Financial Results 5China-Biotics, Inc. Reports First Quarter 2009 Financial Results 6China-Biotics, Inc. Reports First Quarter 2009 Financial Results 7China-Biotics, Inc. Reports First Quarter 2009 Financial Results 8China-Biotics, Inc. Reports First Quarter 2009 Financial Results 9China-Biotics, Inc. Reports First Quarter 2009 Financial Results 10China-Biotics, Inc. Reports First Quarter 2009 Financial Results 11
...
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
2'-Fluorine-CTP (2'-F-CTP) is readily incorporated into transcripts by T7 and SP6 R&DNA™ Polymerase and is available separately....
Monkey IL-2 ELISPOT Kit with white/opague microtiter plates...
Biology Products: